ChemicalBook > CAS DataBase List > 4-Bromo-2-hydroxybenzoic acid

4-Bromo-2-hydroxybenzoic acid

Product Name
4-Bromo-2-hydroxybenzoic acid
CAS No.
1666-28-0
Chemical Name
4-Bromo-2-hydroxybenzoic acid
Synonyms
NSC 109120;4-BROMOSALICYLIC ACID;4-Bromosalicyclic acid;4-Bromosalicylic acid, >=98%;2-Hydroxy-4-bromobenzoicacid;4-bromo-2-hydoxybenzoic acid;4-BROMO-2-HYDROXYBENZOIC ACID;VLOOKUP(C4,[1]Export!$D:$H,5,0);Benzoicacid, 4-bromo-2-hydroxy-;4-Bromo-2-hydroxybenzoic acid 98%
CBNumber
CB4196824
Molecular Formula
C7H5BrO3
Formula Weight
217.02
MOL File
1666-28-0.mol
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4-Bromo-2-hydroxybenzoic acid Property

Melting point:
164-165°C
Boiling point:
330.2±32.0 °C(Predicted)
Density 
1.861±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
2.71±0.10(Predicted)
form 
powder
color 
Orange
InChI
InChI=1S/C7H5BrO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,(H,10,11)
InChIKey
FYAKLZKQJDBBKW-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=C(Br)C=C1O
CAS DataBase Reference
1666-28-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-52/53
Safety Statements 
22-24/25-61
RIDADR 
2811
WGK Germany 
3
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
2918290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
716421
Product name
4-Bromo-2-hydroxybenzoic acid
Purity
97%
Packaging
5g
Price
$147
Updated
2024/03/01
TRC
Product number
B696148
Product name
4-Bromo-2-hydroxybenzoic acid
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB70486
Product name
4-Bromo-2-hydroxybenzoic acid
Packaging
50g
Price
$87.5
Updated
2021/12/16
AK Scientific
Product number
R020
Product name
4-Bromo-2-hydroxybenzoic acid
Packaging
25g
Price
$94
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB70486
Product name
4-Bromo-2-hydroxybenzoic acid
Packaging
25g
Price
$50
Updated
2021/12/16
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4-Bromo-2-hydroxybenzoic acid Chemical Properties,Usage,Production

Chemical Properties

4-Bromo-2-hydroxybenzoic acid is a solid at normal temperature and pressure. It is stable at normal temperature and decomposes into phenol and carbon dioxide after rapid heating. It has some acidic properties.

Uses

2-Hydroxy-4-bromobenzoic acid is used as an anti-scorch agent in drug molecules and rubber industry, as well as an intermediate in the production of ultraviolet absorbers and foaming agents.

Synthesis

Under nitrogen atmosphere, add copper (II) bromide (8.8 g, 39.4 mmol, 1.2 equivalents), acetonitrile (50 ml), and 4-aminosalicylic acid (5.1 g, 49.5 mmol) to the vacuum-dried reaction flask, 1.5 equivalent). The reaction mixture was cooled to 0°C, and 2-hydroxy-4-bromobenzoic acid precursor (5.0 g, 32.6 mmol, 1.0 equiv) was added portion-wise. Additional acetonitrile (25 mL) was added to the mixture and stirred at 0 °C for 2 h. The organic extracts were combined and washed with 20% aqueous hydrochloric acid, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was dissolved in diethyl ether, and the resulting solution was extracted with 15% sodium hydroxide aqueous solution. The aqueous solution was washed with diethyl ether, acidified to pH 1 with 6N hydrochloric acid aqueous solution, and the mixture was extracted with diethyl ether. The combined organic extracts were washed with brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was treated with chloroform, and the precipitate collected by filtration was 4-Bromo-2-hydroxybenzoic acid.

4-Bromo-2-hydroxybenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-2-hydroxybenzoic acid Suppliers

China 215 Germany 2 India 2 Ukraine 1 United Kingdom 9 United States 19 Global 248
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View Lastest Price from 4-Bromo-2-hydroxybenzoic acid manufacturers

Milestone Chemical Wuxi Co.,Ltd
Product
4-Bromo-2-hydroxybenzoic acid 1666-28-0
Price
US $0.00-0.00/kg T
Min. Order
1kg T
Purity
99.9%MIN
Supply Ability
20TONS
Release date
2023-03-20
Henan Aochuang Chemical Co.,Ltd.
Product
4-Bromo-2-hydroxybenzoic acid 1666-28-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Bromo-2-hydroxybenzoic acid 1666-28-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

1666-28-0, 4-Bromo-2-hydroxybenzoic acidRelated Search:

5-Sulfosalicylic acid dihydrate 4-Hydroxybenzoic acid Methylparaben Methyl salicylate 4-Bromobenzoic acid Sodium salicylate 4-HYDROXYBENZOIC ACID N-AMYL ESTER Salicylic acid Butylparaben 3-Hydroxybenzoic acid 4-Bromomethylbenzoic acid Acetylsalicylic acid 4-BROMO-2-METHOXYBENZALDEHYDE 4-Bromo-2-methylphenol 5-BROMO-2-HYDROXYBENZOIC ACID,5-BROMOSALICYLIC ACID / 5-BROMO-2-HYDROXYBENZOIC ACID Bromine 3-BROMO-4-HYDROXYBENZOIC ACID,3-BROMO-4-HYDROXYBENZOIC ACID HYDRATE 4-BROMO-2,5-DIMETHOXYBENZOIC ACID

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  • 1666-28-0
  • C7H5O3Br
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
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