Structure
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4-Bromo-2-hydroxybenzoic acid

Structure
Product Name
4-Bromo-2-hydroxybenzoic acid
CAS No.
1666-28-0
Chemical Name
4-Bromo-2-hydroxybenzoic acid
Synonyms
NSC 109120;4-BROMOSALICYLIC ACID;4-Bromosalicyclic acid;4-Bromosalicylic acid, >=98%;2-Hydroxy-4-bromobenzoicacid;4-bromo-2-hydoxybenzoic acid;4-BROMO-2-HYDROXYBENZOIC ACID;VLOOKUP(C4,[1]Export!$D:$H,5,0);Benzoicacid, 4-bromo-2-hydroxy-;4-Bromo-2-hydroxybenzoic acid 98%
CBNumber
CB4196824
Molecular Formula
C7H5BrO3
Formula Weight
217.02
MOL File
1666-28-0.mol
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4-Bromo-2-hydroxybenzoic acid Property

Melting point:
164-165°C
Boiling point:
330.2±32.0 °C(Predicted)
Density 
1.861±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
2.71±0.10(Predicted)
form 
powder
color 
Orange
InChI
InChI=1S/C7H5BrO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,(H,10,11)
InChIKey
FYAKLZKQJDBBKW-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=C(Br)C=C1O
CAS DataBase Reference
1666-28-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-52/53
Safety Statements 
22-24/25-61
RIDADR 
2811
WGK Germany 
3
HazardClass 
IRRITANT
PackingGroup 
HS Code 
2918290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
716421
Product name
4-Bromo-2-hydroxybenzoic acid
Purity
97%
Packaging
5g
Price
$147
Updated
2024/03/01
TRC
Product number
B696148
Product name
4-Bromo-2-hydroxybenzoic acid
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB70486
Product name
4-Bromo-2-hydroxybenzoic acid
Packaging
50g
Price
$87.5
Updated
2021/12/16
AK Scientific
Product number
R020
Product name
4-Bromo-2-hydroxybenzoic acid
Packaging
25g
Price
$94
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB70486
Product name
4-Bromo-2-hydroxybenzoic acid
Packaging
25g
Price
$50
Updated
2021/12/16
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4-Bromo-2-hydroxybenzoic acid Chemical Properties,Usage,Production

Structure

4-Bromo-2-hydroxybenzoic acid is almost planar (r.m.s. deviation for the non-H atoms = 0.035 Å) and an intra­molecular O—H⋯O hydrogen bond closes an S(6) ring. The plane defined by the non-H atoms of the carboxyl group is twisted slightly by 4.8 (4)° to the mean plane of the phenyl ring. In the crystal, inversion dimers linked by pairs of O—H⋯O hydrogen bonds generate (8) loops. Short Br⋯Br contacts [3.4442 (5) Å] between the mol­ecules of the adjacent (8) dimers leads to a one-dimensional architecture.

Chemical Properties

4-Bromo-2-hydroxybenzoic acid is a solid at normal temperature and pressure. It is stable at normal temperature and decomposes into phenol and carbon dioxide after rapid heating. It has some acidic properties.

Uses

2-Hydroxy-4-bromobenzoic acid is used as an anti-scorch agent in drug molecules and rubber industry, as well as an intermediate in the production of ultraviolet absorbers and foaming agents.

Synthesis

Under nitrogen atmosphere, add copper (II) bromide (8.8 g, 39.4 mmol, 1.2 equivalents), acetonitrile (50 ml), and 4-aminosalicylic acid (5.1 g, 49.5 mmol) to the vacuum-dried reaction flask, 1.5 equivalent). The reaction mixture was cooled to 0°C, and 2-hydroxy-4-bromobenzoic acid precursor (5.0 g, 32.6 mmol, 1.0 equiv) was added portion-wise. Additional acetonitrile (25 mL) was added to the mixture and stirred at 0 °C for 2 h. The organic extracts were combined and washed with 20% aqueous hydrochloric acid, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was dissolved in diethyl ether, and the resulting solution was extracted with 15% sodium hydroxide aqueous solution. The aqueous solution was washed with diethyl ether, acidified to pH 1 with 6N hydrochloric acid aqueous solution, and the mixture was extracted with diethyl ether. The combined organic extracts were washed with brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was treated with chloroform, and the precipitate collected by filtration was 4-Bromo-2-hydroxybenzoic acid.

4-Bromo-2-hydroxybenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-2-hydroxybenzoic acid Suppliers

Milestone Chemical Wuxi Co.,Ltd
Tel
18068271528
Email
1917265470@qq.com
Country
China
ProdList
66
Advantage
58
Suzhou Xiaoli Material Technology Co., Ltd.
Tel
0512-87815088 18015562287
Fax
0512-69233866
Email
xmwang@xiaolitech.com
Country
China
ProdList
68
Advantage
58
Shandong Lingyida Pharmaceutical Technology Co., Ltd
Tel
18762280800 15195955353
Email
2115358020@qq.com
Country
China
ProdList
66
Advantage
58
Suzhou Nordica Biopharma Co.,LTD
Tel
15150674956
Email
dannilee@nordicabio.com
Country
China
ProdList
95
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9513
Advantage
66
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View Lastest Price from 4-Bromo-2-hydroxybenzoic acid manufacturers

Suzhou Nordica Biopharma CO.,LTD
Product
4-Bromosalicylic acid 1666-28-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98% by HPLC
Supply Ability
20 tons
Release date
2024-09-19
Milestone Chemical Wuxi Co.,Ltd
Product
4-Bromo-2-hydroxybenzoic acid 1666-28-0
Price
US $0.00-0.00/kg T
Min. Order
1kg T
Purity
99.9%MIN
Supply Ability
20TONS
Release date
2023-03-20
Henan Aochuang Chemical Co.,Ltd.
Product
4-Bromo-2-hydroxybenzoic acid 1666-28-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-14

1666-28-0, 4-Bromo-2-hydroxybenzoic acidRelated Search:


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  • 4-BROMO-2-HYDROXYBENZOIC ACID
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  • 2-Hydroxy-4-bromobenzoicacid
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  • 4-Bromosalicyclic acid
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  • 4-Bromosalicylic acid, >=98%
  • NSC 109120
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  • VLOOKUP(C4,[1]Export!$D:$H,5,0)
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