ChemicalBook > CAS DataBase List > ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE

ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE

Product Name: ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
CAS No.: 22900-83-0
Chemical Name: ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
Synonyms: ETHYL 2-BROMO-4-METHYLTHIAZOLE-5-CARBOXYLATE;2-bromo-4-methylthiazole-5-carboxylate;ETHYL 2-BROMO-4-METHYLTHIAZOLE-5-CARBOX&;Ethyl 2-bromo-4-methylthiazol-5-carboxylate;Ethyl 2-Bromo-4-methyl-5-thiazolecarboxylate;Ethyl 2-broMo-4-Methylthiazole-5-carboxylate 97%;Ethyl 2-Bromo-4-methylthiazole-5-carboxylate >Ethyl 2-bromop4-methyl-1,3-thiazole-5-carboxylate;ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE;2-Bromo-4-methyl-5-thiazolecarboxylic acid ethyl ester
CBNumber: CB4205566
Molecular Formula: C7H8BrNO2S
Formula Weight: 250.11
MOL File: 22900-83-0.mol

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ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Property

Melting point:: 65-69 °C(lit.)
Boiling point:: 287.1±20.0 °C(Predicted)
Density: 1.573±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: -0.10±0.10(Predicted)
color: Light yellow to Brown
Water Solubility: Insoluble in water.
InChI: InChI=1S/C7H8BrNO2S/c1-3-11-6(10)5-4(2)9-7(8)12-5/h3H2,1-2H3
InChIKey: CFBIOWPDDZPIDP-UHFFFAOYSA-N
SMILES: S1C(C(OCC)=O)=C(C)N=C1Br

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-41
Safety Statements: 26-36
RIDADR: 1759
WGK Germany: 3
HazardClass: IRRITANT
PackingGroup: Ⅲ
HS Code: 29341000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 645990
Product name: Ethyl 2-bromo-4-methylthiazole-5-carboxylate
Purity: 97%
Packaging: 1g
Price: $54.1
Updated: 2023/01/07

Sigma-Aldrich

Product number: 645990
Product name: Ethyl 2-bromo-4-methylthiazole-5-carboxylate
Purity: 97%
Packaging: 5g
Price: $207
Updated: 2023/01/07

TCI Chemical

Product number: E0945
Product name: Ethyl 2-Bromo-4-methylthiazole-5-carboxylate
Purity: >97.0%(GC)
Packaging: 1g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: E0945
Product name: Ethyl 2-Bromo-4-methylthiazole-5-carboxylate
Purity: >97.0%(GC)
Packaging: 5g
Price: $132
Updated: 2024/03/01

TRC

Product number: E900558
Product name: Ethyl 2-Bromo-4-methylthiazole-5-carboxylate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

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ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

It finds its application in the preparation of thiazole-4- and -5-carboxylates, and an infrared study of their rotational isomers and in the discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects.

Synthesis

7210-76-6

22900-83-0

General procedure for the synthesis of ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate from ethyl 2-amino-4-methylthiazole-5-carboxylate: first, 2-methyl-1-nitro-propyl-propene (28.2 mL, 2.1 eq.) was dissolved in acetonitrile (700 mL) and the solution was cooled to 0 °C. Subsequently, bromo-trimethyl-silane (32 mL , 2.1 eq.). The reaction mixture was maintained at 0°C. Next, ethyl 2-amino-4-methyl-thiazole-5-carboxylate (18.6 g, 0.1 mol) was added to an acetonitrile/ethyl acetate (75/25) solution. After the dropwise addition was completed, the reaction mixture continued to be kept at 0°C. The mixture was warmed to room temperature and stirred for 24 hours. After completion of the reaction, the solvent was removed by evaporation and water was added. The product was extracted with ethyl acetate, the organic phase was dried with anhydrous sodium sulfate, filtered and concentrated. Finally, purification by fast chromatography using dichloromethane as eluent gave ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate as a yellow solid (21.74 g, 87 mmol, 87% yield); GC/MS analysis: [M+] C7H8BrNO2S 250.

References

[1] Patent: WO2004/6923, 2004, A1. Location in patent: Page/Page column 38
[2] Patent: WO2004/6924, 2004, A1. Location in patent: Page/Page column 31-32
[3] Patent: WO2004/7493, 2004, A1. Location in patent: Page 24-25
[4] Patent: EP2518054, 2012, A1. Location in patent: Page/Page column 53
[5] Patent: WO2008/47109, 2008, A1. Location in patent: Page/Page column 38

ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Suppliers

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View Lastest Price from ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE 22900-83-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-20

22900-83-0, ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATERelated Search:

Sulfathiazole Ethyl 4-methyl-5-thiazoleactate Thiazole-5-carboxylic acid Ethyl thiazole-5-carboxylate 4-Methylthiazole-5-carboxylic acid 2-Amino-5-formylthiazole Methyl 2-bromothiazole-5-carboxylate 2-Bromo-5-methylthiazole 2-Bromo-4-thiazolecarboxylic acid Ethyl 2-bromothiazole-5-carboxylate 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID 2-Bromo-4-methylthiazole 2-Bromothiazole 2-BROMO-5-HYDROXYMETHYLTHIAZOLE ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE 2-BROMO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 5-Thiazolecarboxylicacid,2-bromo-4-methyl-,methylester(9CI) 5-Thiazolecarboxylicacid,2-bromo-4-(1,1-dimethylethyl)-,ethylester(9CI)

ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE

ETHYL 2-BROMO-4-METHYLTHIAZOLE-5-CARBOXYLATE

ETHYL 2-BROMO-4-METHYLTHIAZOLE-5-CARBOX&

Ethyl 2-bromop4-methyl-1,3-thiazole-5-carboxylate

2-bromo-4-methyl-thiazole-5-carboxylic acid ethyl ester

2-Bromo-4-methyl-5-thiazolecarboxylic acid ethyl ester

2-bromo-4-methylthiazole-5-carboxylate

Ethyl 2-broMo-4-Methylthiazole-5-carboxylate

Ethyl 2-broMo-4-Methylthiazole-5-carboxylate 97%

JR-8414, Ethyl 2-bromo-4-methylthiazole-5-carboxylate, 97%

Ethyl 2-Bromo-4-methyl-5-thiazolecarboxylate

Ethyl 2-Bromo-4-methylthiazole-5-carboxylate &gt

5-Thiazolecarboxylic acid, 2-bromo-4-methyl-, ethyl ester

5-Thiazolecarboxylic acid, 2-bromo-4-methyl-, ethyl ester (8CI, 9CI, ACI)

2-bromo-4-methyl-5-Thiazolecarboxylic acid ethyl ester (8CI 9CI ACI)

Ethyl 2-bromo-4-methylthiazol-5-carboxylate

22900-83-0

Thiazoles

Halogenated Heterocycles

Heterocyclic Building Blocks

Building Blocks

thiazole, carboxylate

Thiazole series

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Thiazoles

ThiazolesHeterocyclic Building Blocks