Cryptotanshinone

Product Name: Cryptotanshinone
CAS No.: 35825-57-1
Chemical Name: Cryptotanshinone
Synonyms: CRYPTOTANSHINONE;Cryptotanshinon;Cryptotanshinone, Tanshinone c;CS-1284;98% BY HPLC;Tanshinone c;Cryptotanshine;Noncrystalline;yindanshentong;Crypttanshinone
CBNumber: CB4222031
Molecular Formula: C19H20O3
Formula Weight: 296.36
MOL File: 35825-57-1.mol

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Cryptotanshinone Property

Melting point:: 192°C(lit.)
Boiling point:: 459.0±45.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥5mg/mL
form: powder
color: orange-brown
optical activity: [α]/D -85.0±3.0°, c = 0.1 in chloroform
λmax: 263nm(lit.)
BRN: 5445400
InChIKey: IJSBKZLSTIFYIE-FPKDZHNTSA-N
LogP: 4.130 (est)
CAS DataBase Reference: 35825-57-1(CAS DataBase Reference)

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Safety

Hazard Codes: T,N
Risk Statements: 25-50/53
Safety Statements: 45-60-61
RIDADR: UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany: 3
RTECS: SF8282645
HazardClass: 6.1
PackingGroup: III
HS Code: 29321900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89612
Product name: Cryptotanshinone
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $584
Updated: 2024/03/01

TCI Chemical

Product number: C3363
Product name: Cryptotanshinone
Purity: >97.0%(HPLC)
Packaging: 25mg
Price: $152
Updated: 2024/03/01

TCI Chemical

Product number: C3363
Product name: Cryptotanshinone
Purity: >97.0%(HPLC)
Packaging: 100mg
Price: $303
Updated: 2024/03/01

Cayman Chemical

Product number: 16987
Product name: Cryptotanshinone
Purity: ≥95%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16987
Product name: Cryptotanshinone
Purity: ≥95%
Packaging: 10mg
Price: $57
Updated: 2024/03/01

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Cryptotanshinone Chemical Properties,Usage,Production

Chemical Properties

Orange powder

Uses

inhibits angiogenesis

Uses

Cryptotanshinone (CPT), a lipophilic diterpene derived from the roots of Salvia miltiorrhiza Bge and Salvia przewalskii Maxim, may be used to study its multiple bioactivities as an antibacterial, antidermatophytic, antioxidant, anti-inflammatory and anticancer agent. Cryptotanshinone may also be studied as a differentiation factor.

Definition

ChEBI: Cryptotanshinone is an abietane diterpenoid. It has a role as an anticoronaviral agent.

General Description

Cryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr⁷⁰⁵ phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 μM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 μM). Cryptotanshinone is also reported to deplete cellular ATP level (by 75% in 12 h at 20 μM in C2C12 myotubes), resulting in an indirect activation of cellular AMPK pathways and an enhancement of insulin-stimulated cellular glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes (by ~1.3- and 1.9-fold, respectively). Cryptotanshinone is demonstrated to be an orally active hypoglycemic agent in ob/ob mice, db/db mice, and ZDF rats in vivo (600 mg/kg/day).

Biological Activity

Major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC 50 = 4.6 μ ). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC 50 = 4.09 μ ) and reduction in A β peptide generation.

Biochem/physiol Actions

Cryptotanshinone is an antibacterial and anti-inflammatory compound originally extracted from the roots of Salvia miltiorrhiaz (danshen). Cryptotanshinone has been found to inhibit HIF activation and to inhibit macrophage migration negatively regulate the PI3K pathway. It has demonstrated activity against several strains of Staphylococcus aureus.

Cytotoxicity

IC50 (μg/mL): 1.27 (A549), 1.39 (TOV-21G) (Chang et al. 2013)

storage

Room temperature

Cryptotanshinone Preparation Products And Raw materials

Raw materials

Preparation Products

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Cryptotanshinone Suppliers

Americas 1 China 314 Czech Republic 1 Europe 1 Germany 2 India 2 Japan 1 United Kingdom 12 United States 35 Global 369

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View Lastest Price from Cryptotanshinone manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Cryptotanshinone 35825-57-1
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-25

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Cryptotanshinone 35825-57-1 35825-57-1
Price: US $5.00/mg
Min. Order: 20mg
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: Cryptotanshinone 35825-57-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

35825-57-1, CryptotanshinoneRelated Search:

Baicalin Berberine Curcumol Resveratrol Borneol Gastrodin Salvia Root P.E Tanshinone IIA 20% TANSHINONE ⅡA Retinoic acid (+)-Camptothecin Cryptochlorogenic acid illudin S Leucocrystal Violet NOTOGINSENG RADIX ET RHIZOMA Rhodiola Crenulate(tibetan Ginseng) Salidroside 1-5%,Rosavins 3% HPLC Cryptotanshinone 1,2-NAPHTHOQUINONE 1,5-DIMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE

CRYPTOTANSHINONE

98% BY HPLC

CRYPTOTANSHINONE &gt

TANSHINONE, CRYPTO(P)

(r)-1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione

TANSHINONE, CRYPTO

hexahydro-1,6,6-trimethyl-,(R)-

Phenanthro[1,2-b]furan-10,11-dione,1,2,6,7,8,9-

1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl[1,2-b]furan-10,11-dione

Cryptotanshinone - CAS 35825-57-1 - Calbiochem

Cryptotanshinone, Tanshinone c

CS-1284

Cryptotanshinone, 98%, from Salvia miltiorrhiza

Cryptotanshinone 35825-57-1

(1R)-1,6,6-trimethyl-2,3a,7,8,9,11a-hexahydro-1H-naphtho[1,2-g]benzofuran-10,11-dione

Cryptotanshine

Cryototanshinone

Cryptotanshinon

Tanshinone c

Phenanthro[1,2-b]furan-10,11-dione, 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-, (1R)-

Cryptotanshinone (R)-1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione

1,2,6,7,8,9-hexahydro-1,6,6-trimethyl- (R)-phenanthro(1,2-b)furan-10,11-dione

Cryptotanshinone, froM Salvia Miltiorrhiza

Cryptotanshinone, 98%, from Salvia miltiorrhiza Bunge

(R)-1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione USP/EP/BP

Crypttanshinone

Noncrystalline

Phenanthro[1,2-b]furan-10,11-dione,1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-, (R)-

Cryptotanshinone (Cryptotanshinon)

yindanshentong

Cryptotanshinone POWDER

Cryptotanshinon|||Tanshinone c

Cryptotanshinone-RM

35825-57-1

35825-57-2

Anthraquinones, Hydroquinones and Quinones

The group of Danshen

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Herb extract

Inhibitors