(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid

Product Name: (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid
CAS No.: 140148-70-5
Chemical Name: (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid
Synonyms: (S)-1-N-BOC-BETA-PROLINE;N-Boc-L-beta-p;BOC-L-B-PROLINE;(3S)-Boc-β-Pro-OH;(3S)-BOC-BETA-PRO-OH;N-Boc-L-beta-proline;1-N-Boc-delta-Proline;N-Boc-L-^b-proline,95%;N-Boc-L-^b-proline, 95%;(3S)-Boc-β-Pro-OH
CBNumber: CB4225931
Molecular Formula: C10H17NO4
Formula Weight: 215.25
MOL File: 140148-70-5.mol

More

Less

(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid Property

Melting point:: 140-145°C
Boiling point:: 337.2±35.0 °C(Predicted)
Density: 1.201±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 4.47±0.20(Predicted)
form: solid
Appearance: White to off-white Solid
optical activity: [α]/D +15.0°, c = 0.5% in chloroform
Water Solubility: Soluble in water (slightly).
InChI: InChI=1S/C10H17NO4/c1-10(2,3)15-9(14)11-5-4-7(6-11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m0/s1
InChIKey: HRMRQBJUFWFQLX-ZETCQYMHSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC[C@H](C(O)=O)C1
CAS DataBase Reference: 140148-70-5(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi,N
Risk Statements: 41-50
Safety Statements: 26-39-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HS Code: 29333990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS005246
Product name: (3S)-Boc-β-Pro-OH
Purity: Aldrich
Packaging: 100mg
Price: $73.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 735507
Product name: (S)-1-Boc-3-pyrrolidinecarboxylic acid
Purity: 97%
Packaging: 500mg
Price: $108.68
Updated: 2025/07/31

TRC

Product number: B661975
Product name: (S)-1-Boc-Pyrrolidine-3-carboxylicAcid
Packaging: 2.5g
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 261906
Product name: N-Boc-D-proline
Packaging: 25g
Price: $330
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 38242
Product name: (3S)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylicacid
Packaging: 1g
Price: $350
Updated: 2021/12/16

More

Less

(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White to light brown solid

Uses

N-Boc-L-beta-proline is an important raw material and intermediate used in pharmaceuticals, agrochemicals and dyestuff.

Synthesis

122684-33-7

72925-16-7

General procedure for the synthesis of (R)-1-Boc-3-carboxypyrrolidine from methyl 1-Boc-pyrrolidine-3-carboxylate: sodium hydroxide (0.80 g, 20.00 mmol) was dissolved in water (15 mL), and this solution was added to a methanol (30 mL) solution of methyl 1-Boc-pyrrolidine-3-carboxylate (2.30 g, 10.00 mmol). . The reaction mixture was allowed to react for 3 hours with stirring at room temperature. After the reaction was completed, the methanol was removed by concentration under reduced pressure. The pH of the remaining aqueous solution was adjusted to 4 with 2 M glacial acetic acid and then extracted with dichloromethane (50 mL x 3). The organic phases were combined and dried with anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give 1.80 g of an oily product in 83.00% yield.

References

[1] Organic Letters, 2005, vol. 7, # 15, p. 3287 - 3289
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 1, p. 94 - 104
[3] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682
[4] Patent: CN106336413, 2017, A. Location in patent: Paragraph 0453; 0454; 0455
[5] Journal of Medicinal Chemistry, 1990, vol. 33, # 7, p. 2052 - 2059

(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid Suppliers

China 185 Europe 1 France 1 Germany 4 India 3 United Kingdom 3 United States 24 Global 221

Carbosynth

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

Fluorochem Ltd

Tel: --
Fax: --
Email: vernam@fluorochem.co.uk
Country: United Kingdom
ProdList: 6375
Advantage: 65

More

Less

View Lastest Price from (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid manufacturers

Honest Joy Holdings Limited

Product: (S)-1-Boc-pyrrolidine-3-carboxylic acid 140148-70-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 100 tons
Release date: 2022-01-26

Career Henan Chemical Co

Product: (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid 140148-70-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-24

140148-70-5, (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acidRelated Search:

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 2-(N,N-DIMETHYLAMINOMETHYL)PHENYLBORONIC ACID Ethyl 1-Boc-3-pyrrolidinecarboxylate (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid BOC-D-PROLINE HYDROXYSUCCINIMIDE ESTER,BOC-D-PROLINE-OSU,BOC-D-PROLINE N-HYDROXYSUCCINIMIDE ESTER,BOC-D-PROLINE HYDROXYSUCCINIMIDESTER (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid N-Boc-D-proline,N-BOC-D-PROLINE-OH,BOC-D-PROLINE,BOC-D-PROLINE-OH,N-Boc-D-proline, 98+%,BOC-D-PROLINE extrapure BOC-DL-PROLINE,N-BOC-DL-PROLINE 1-N-BOC-BELTA-PROLINE,1-N-BOC-BETA-PROLINE (4S)-4-N-FMOC-AMINO-1-BOC-L-PROLINE Methyl 1-Boc-3-pyrrolidinecarboxylate BOC-L-Proline BOC-DL-PROLINE ETHYL ESTER BOC-L-PROLINE HYDROXYSUCCINIMIDESTER,N-Boc-L-Proline succinimidyl ester L-N-[(4&#39-Boc)piperidino]proline (R)-1-N-Boc-beta-proline 3-Pyrrolidinecarboxylic acid 1-Boc-Pyrrolidine

(S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid

(3S)-Boc-β-Pro-OH

1,3-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (3S)-

(3S)-1-Boc-3-pyrrolidinecarboxylic acid

N-Boc-L-beta-proline

(S)-3-Carboxypyrrolidine-1-carboxylic acidtert-butyl ester

BOC-L-B-PROLINE

BOC-(3S)-1-PYRROLIDINE-3-CARBOXYLIC ACID

(3S)-BOC-1-PYRROLIDINE-3-CARBOXYLIC ACID

(3S)-BOC-BETA-PRO-OH

(3s)-1-(tert-butoxycarbonyl)-3-pyrrolidinecarboxylic acid

(S)-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

(S)-N-BOC-PYRROLIDINE-3-CARBOXYLIC ACID

S-1-BOC-PYRROLIDINE-3-CARBOXYLIC ACID

(S)-1-N-BOC-BETA-PROLINE

1-N-Boc-pyrrolidine-3(S)-carboxylic acid

1-N-Boc-delta-Proline

(3S)-1-(tertbutoxycarbonyl)pyrrolidine-3-carboxylic acid

(S)-1-N-BOC-PYRROLIDINE-3-CARBOXYLICACID

R-1-BOC-3-PYRROLIDINECARBOXYLIC ACID

1-N-boc-3-pyrrolidinecarboxylate

1-(TERT-BUTOXYCARBONYL)-3-PYRROLIDINECARBOXYLIC ACID

N-Boc-L-^b-proline, 95%

(S)-1-Boc-3-pyrrolidinecarboxylic Acid

N-Boc-S-3-Pyrrolidinecarboxylic acid

N-Boc-L-beta-p

(S)-1-Boc-3-carboxylic'acid'pyrrolidine

N-Boc-L-^b-proline,95%

140148-70-5 C10H17NO4 (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid

(3S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid

1-Propanol,3-[(tetrahydro-2H-pyran-5-yl)oxy]-

1-(1,1-Dimethylethyl) (3S)-1,3-pyrrolidinedicarboxylate

(S)-1-Boc-pyrrolidine-3-carboxylic acid?New

(<i>S</i>)-1-Boc-3-pyrrolidinecarboxylic acid

(3<i>S</i>)-Boc-β-Pro-OH

1-(tert-Butyl) (3S)-1,3-pyrrolidinedicarboxylate

140148-70-5

pharmacetical

Pyrrole&Pyrrolidine&Pyrroline