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Tri(Ethylene Glycol) DI-P-Toluenesulfonate

Product Name
Tri(Ethylene Glycol) DI-P-Toluenesulfonate
CAS No.
19249-03-7
Chemical Name
Tri(Ethylene Glycol) DI-P-Toluenesulfonate
Synonyms
(Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-Methylbenzenesulfonate);1,10-Ditosyl-1,4,7,10-tetraoxadecane;TRIETHYLENE GLYCOL DITOSYLATE;TRIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE);Tos-PEG4-Tos;Tos-PEG3-Tos;Bis-Tos-PEG3;TSO-PEG3-OTS;CAS_19249-03-7;Trivinyl glycol
CBNumber
CB4227531
Molecular Formula
C20H26O8S2
Formula Weight
458.55
MOL File
19249-03-7.mol
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Tri(Ethylene Glycol) DI-P-Toluenesulfonate Property

Melting point:
78-82 °C(lit.)
Boiling point:
534.03°C (rough estimate)
Density 
1.3164 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in ethanol.
form 
powder to crystal
color 
White to Almost white
BRN 
632509
InChI
InChI=1S/C20H26O8S2/c1-17-3-7-19(8-4-17)29(21,22)27-15-13-25-11-12-26-14-16-28-30(23,24)20-9-5-18(2)6-10-20/h3-10H,11-16H2,1-2H3
InChIKey
KCONMNWPRXAWKK-UHFFFAOYSA-N
SMILES
C(OCCOS(C1=CC=C(C)C=C1)(=O)=O)COCCOS(C1=CC=C(C)C=C1)(=O)=O
CAS DataBase Reference
19249-03-7(CAS DataBase Reference)
EPA Substance Registry System
Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, bis(4-methylbenzenesulfonate) (19249-03-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
339032
Product name
Triethylene glycol di(p-toluenesulfonate)
Purity
98%
Packaging
10g
Price
$56.5
Updated
2025/07/31
TCI Chemical
Product number
T1488
Product name
Triethylene Glycol Bis(p-toluenesulfonate)
Purity
>97.0%(HPLC)
Packaging
10g
Price
$76
Updated
2025/07/31
TCI Chemical
Product number
T1488
Product name
Triethylene Glycol Bis(p-toluenesulfonate)
Purity
>97.0%(HPLC)
Packaging
25g
Price
$130
Updated
2025/07/31
TRC
Product number
E917743
Product name
(Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl)bis(4-Methylbenzenesulfonate)
Packaging
50mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
J96812
Product name
Tri(ethylene glycol) di-p-toluenesulfonate
Packaging
1g
Price
$10
Updated
2021/12/16
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Tri(Ethylene Glycol) DI-P-Toluenesulfonate Chemical Properties,Usage,Production

Description

Tos-PEG4-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Chemical Properties

WHITE POWDER

Uses

Tri(ethylene glycol) di-p-toluenesulfonate is used in the synthesis of 1-[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl] ethanone.

Synthesis

2,2'-[1,2-ethanediylbis(oxy)]bisethanol and p-toluenesulfonyl chloride can be used as raw materials for the synthesis of Tri(Ethylene Glycol) DI-P-Toluenesulfonate.

References

[1] Organic and Biomolecular Chemistry, 2006, vol. 4, # 11, p. 2082 - 2087
[2] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 14, p. 4841 - 4856
[3] Organic and Biomolecular Chemistry, 2015, vol. 13, # 30, p. 8335 - 8348
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 17, p. 7840 - 7855
[5] Journal of Organic Chemistry, 1992, vol. 57, # 24, p. 6678 - 6680

Tri(Ethylene Glycol) DI-P-Toluenesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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Tri(Ethylene Glycol) DI-P-Toluenesulfonate Suppliers

Belgium 2 Canada 2 China 207 Germany 3 India 6 Japan 3 Switzerland 1 United Kingdom 7 United States 19 Global 250
SIGMA-RBI
Tel
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Fax
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Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from Tri(Ethylene Glycol) DI-P-Toluenesulfonate manufacturers

XIAMEN SINOPEG BIOTECH CO., LTD.
Product
(ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) 19249-03-7
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
1g/bottle, 10g/bottle, 100g/bottle
Release date
2025-09-24
Xian confluore Biological Technology Co., Ltd.
Product
Tos-PEG4-Tos 19249-03-7
Price
US $0.00/g
Min. Order
500g
Purity
>98.00%
Supply Ability
500g
Release date
2024-03-27
Zhuozhou Wenxi import and Export Co., Ltd
Product
TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE 19249-03-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

19249-03-7, Tri(Ethylene Glycol) DI-P-ToluenesulfonateRelated Search:

2,2-Dimethyl-1,3-propanediol Triethylene glycol dimethacrylate Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate) ALLYL ISOVALERATE Magnesium Bisglycinate 4-FLUORO-3'-IODODIPHENYL ETHER 5-NITRO-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER 1-CBZ-2-PIPERIDINECARBOXYLIC ACID Risedronic acid Benzonitrile, 3-bromo-2-fluoro- (9CI) Tos-PEG3-t-butyl ester TETRAETHYLENE GLYCOL DI-P-TOSYLATE TOS-PEG5-THP Tos-PEG7-t-butyl ester Tos-PEG9-t-butyl ester Tos-PEG5-CH2CO2t-butyl ester Tos-PEG13-t-butyl ester Tos-PEG3-CH2CO2tBu

  • 1,10-Ditosyl-1,4,7,10-tetraoxadecane
  • 1,8-Bis(tosyloxy)-3,6-dioxaoctane
  • Bis(4-methylbenzenesulfonic acid)3,6-dioxa-1,8-octanediyl ester
  • Bis(4-methylbenzenesulfonic acid)ethylenebis(oxyethylene) ester
  • Bis(p-toluenesulfonic acid)ethylenebisoxybisethylene ester
  • Triethylene glycol di-p-tosylate,98%
  • Triethleneglycol ditosylate
  • Triethylene glycol ditoluenesulfonate.
  • ETHANOL22OXYBIS21ETHANEDIYLOXYBISBIS4METHYLBENZENESULPHONATE
  • ethanol,2,2'-[oxybis(2,1-ethanediyloxy)]bis-,bis(4-methysbenzenesulfonate)
  • 2,2μ-(Ethylenedioxy)diethyl ditosylate, Triethylene glycol ditosylate
  • 1,2-Bis[2-(p-toluenesulfonyloxy)ethoxy]ethane(PEG3-Tos)
  • 4-methylbenzenesulfonic acid 2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethyl ester
  • CAS_19249-03-7
  • 1,2-Bis[2-(p-toluenesulfonyloxy)ethoxy]ethane 1,2-Bis(2-tosyloxyethoxy)ethane 2,2'-(Ethylenedioxy)diethyl Ditosylate Triethylene Glycol Di-p-tosylate
  • (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-Methylbenzenesulfonate)
  • Tos-PEG4-Tos
  • Tos-PEG3-Tos
  • PEG3-Tos 1,2-Bis[2-(p-toluenesulfonyloxy)ethoxy]ethane
  • Triethylene glycol bis(p-toluenesulfonate)≥ 98%(HPLC)
  • TRIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)
  • TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE
  • TRIETHYLENE GLYCOL DI-P-TOSYLATE
  • TRIETHYLENE GLYCOL DITOSYLATE
  • TRIETHYLGLYCOL DI-P-TOSYLATE
  • LABOTEST-BB LT00248460
  • 2,2'-(ETHYLENEDIOXY)DIETHYL DITOSYLATE
  • 1,2-BIS[2-(P-TOLUENESULFONYLOXY)ETHOXY]ETHANE
  • 1,2-BIS(2-TOSYLOXYETHOXY)ETHANE
  • 2,2-(Ethylenedioxy)diethyl ditosylat
  • Bis-Tos-PEG3
  • Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, 1,1'-bis(4-methylbenzenesulfonate)
  • 2-2-2-(p-Tolylsulfonyloxy)ethoxyethoxyethyl 4-methylbenzenesulfonate
  • 2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethyl4-methylbenzenesulfonate
  • Triethyleneglycol-di-p-toluenesulphonate
  • Triethylene glycol di(p-toluenesulfonate) 19249-03-7
  • TosO-(CH2CH2O)3-Tos
  • Tos-PEG3-Tos/Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, 1,1'-bis(4-methylbenzenesulfonate)
  • (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) , Triethylene glycol bis(p-toluenesulfonate)
  • 2-(2-{2-[(4-methylbenzenesulfonyl)oxy]ethoxy}ethoxy)ethyl 4-methylbenzene-1-sulfonate
  • Triethylene glycol di(<i>p</i>-toluenesulfonate)
  • Trivinyl glycol
  • (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfote)
  • TSO-PEG3-OTS
  • 19249-03-7
  • C20H26O8S2
  • CH3C6H4SO3CH2CH2OCH22
  • Organic Building Blocks
  • Sulfur Compounds
  • Tosylates
  • Building Blocks