2,4'-Dibromoacetophenone
- Product Name
- 2,4'-Dibromoacetophenone
- CAS No.
- 99-73-0
- Chemical Name
- 2,4'-Dibromoacetophenone
- Synonyms
- 99-73-0;2-BROMO-1-(4-BROMOPHENYL)ETHAN-1-ONE;PBPB;2-BROMO-1-(4-BROMOPHENYL)ETHANONE;P-BROMOPHENACYL BROMIDE;4-BROMOPHENACYL BROMIDE;p-bromophenacyl-8;AKOS BBS-00000865;GSK-3β Inhibitor VII;BromophenacylBromide
- CBNumber
- CB4239093
- Molecular Formula
- C8H6Br2O
- Formula Weight
- 277.94
- MOL File
- 99-73-0.mol
2,4'-Dibromoacetophenone Property
- Melting point:
- 108-110 °C(lit.)
- Boiling point:
- 1415°C/760mm
- Density
- 1.7855 (rough estimate)
- refractive index
- 1.5560 (estimate)
- storage temp.
- Store below +30°C.
- solubility
- DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): insol
- form
- Crystalline Solid
- color
- Slightly yellow to beige
- Water Solubility
- Soluble in dimethyl sulfoxide (5 mg/ml), methanol (20 mg/ml), toluene and ethanol. Insoluble in water.
- Sensitive
- Lachrymatory
- Merck
- 14,1427
- BRN
- 607604
- Stability:
- Stable. Incompatible with strong bases, strong reducing agents, strong oxidizing agents.
- InChIKey
- FKJSFKCZZIXQIP-UHFFFAOYSA-N
- CAS DataBase Reference
- 99-73-0(CAS DataBase Reference)
- EPA Substance Registry System
- Ethanone, 2-bromo-1-(4-bromophenyl)- (99-73-0)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 2
- RTECS
- AM6950000
- F
- 19-21
- Hazard Note
- Corrosive/Lachrymatory
- TSCA
- T
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29147090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 68082
- Product name
- 2,4′-Dibromoacetophenone
- Purity
- for HPLC derivatization, ≥99.0% (HPLC)
- Packaging
- 5g
- Price
- $78.3
- Updated
- 2024/03/01
- Product number
- 361548
- Product name
- GSK-3β Inhibitor VII
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- A5501
- Product name
- 4-Bromophenacyl Bromide [for HPLC Labeling]
- Purity
- >99.0%(T)
- Packaging
- 5g
- Price
- $115
- Updated
- 2024/03/01
- Product number
- D0164
- Product name
- 4-Bromophenacyl Bromide
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $35
- Updated
- 2024/03/01
- Product number
- A13687
- Product name
- 2,4'-Dibromoacetophenone, 98+%
- Packaging
- 25g
- Price
- $62.65
- Updated
- 2024/03/01
2,4'-Dibromoacetophenone Chemical Properties,Usage,Production
Chemical Properties
2,4'-Dibromoacetophenone is off-white crystals or powder
Uses
Identification of carboxylic acids.
Uses
Undergoes condensation reactions with aldehydes in the presence of SnCl21 or SmI32 to afford α,β-unsaturated ketones. Also useful in the esterification of carboxylic acids.3
Uses
2,4'-Dibromoacetophenone is used as a reagent for analysis of fatty acids by HPLC as 4-bromophenacyl esters, for use in the protection of phenols and carboxylic acids. It undergoes condensation reactions with aldehydes in the presence of SnCl2 or SmI3 to afford α,β-unsaturated ketones. It is also useful in the esterification of carboxylic acids.
General Description
A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 0.5 μM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM.
Biochem/physiol Actions
Cell permeable: yes
Purification Methods
Crystallise the bromide from EtOH (ca 8mL/g). [Beilstein 7 IV 652.]
2,4'-Dibromoacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4'-Dibromoacetophenone manufacturers
- Product
- 2,4'-Dibromoacetophenone 99-73-0
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- 2,4'-Dibromoacetophenone 99-73-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-31
- Product
- 2,4'-Dibromoacetophenone 99-73-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-08-31