ChemicalBook > CAS DataBase List > 2,4'-Dibromoacetophenone

2,4'-Dibromoacetophenone

Product Name
2,4'-Dibromoacetophenone
CAS No.
99-73-0
Chemical Name
2,4'-Dibromoacetophenone
Synonyms
99-73-0;2-BROMO-1-(4-BROMOPHENYL)ETHAN-1-ONE;PBPB;2-BROMO-1-(4-BROMOPHENYL)ETHANONE;P-BROMOPHENACYL BROMIDE;4-BROMOPHENACYL BROMIDE;p-bromophenacyl-8;AKOS BBS-00000865;GSK-3β Inhibitor VII;BromophenacylBromide
CBNumber
CB4239093
Molecular Formula
C8H6Br2O
Formula Weight
277.94
MOL File
99-73-0.mol
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2,4'-Dibromoacetophenone Property

Melting point:
108-110 °C(lit.)
Boiling point:
1415°C/760mm
Density 
1.7855 (rough estimate)
refractive index 
1.5560 (estimate)
storage temp. 
Store below +30°C.
solubility 
DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): insol
form 
Crystalline Solid
color 
Slightly yellow to beige
Water Solubility 
Soluble in dimethyl sulfoxide (5 mg/ml), methanol (20 mg/ml), toluene and ethanol. Insoluble in water.
Sensitive 
Lachrymatory
Merck 
14,1427
BRN 
607604
Stability:
Stable. Incompatible with strong bases, strong reducing agents, strong oxidizing agents.
InChIKey
FKJSFKCZZIXQIP-UHFFFAOYSA-N
CAS DataBase Reference
99-73-0(CAS DataBase Reference)
EPA Substance Registry System
Ethanone, 2-bromo-1-(4-bromophenyl)- (99-73-0)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3261 8/PG 2
WGK Germany 
2
RTECS 
AM6950000
F 
19-21
Hazard Note 
Corrosive/Lachrymatory
TSCA 
T
HazardClass 
8
PackingGroup 
III
HS Code 
29147090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
68082
Product name
2,4′-Dibromoacetophenone
Purity
for HPLC derivatization, ≥99.0% (HPLC)
Packaging
5g
Price
$78.3
Updated
2024/03/01
Sigma-Aldrich
Product number
361548
Product name
GSK-3β Inhibitor VII
Packaging
5mg
Price
$172
Updated
2024/03/01
TCI Chemical
Product number
A5501
Product name
4-Bromophenacyl Bromide [for HPLC Labeling]
Purity
>99.0%(T)
Packaging
5g
Price
$115
Updated
2024/03/01
TCI Chemical
Product number
D0164
Product name
4-Bromophenacyl Bromide
Purity
>98.0%(GC)
Packaging
25g
Price
$35
Updated
2024/03/01
Alfa Aesar
Product number
A13687
Product name
2,4'-Dibromoacetophenone, 98+%
Packaging
25g
Price
$62.65
Updated
2024/03/01
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2,4'-Dibromoacetophenone Chemical Properties,Usage,Production

Chemical Properties

2,4'-Dibromoacetophenone is off-white crystals or powder

Uses

Identification of carboxylic acids.

Uses

Undergoes condensation reactions with aldehydes in the presence of SnCl21 or SmI32 to afford α,β-unsaturated ketones. Also useful in the esterification of carboxylic acids.3

Uses

2,4'-Dibromoacetophenone is used as a reagent for analysis of fatty acids by HPLC as 4-bromophenacyl esters, for use in the protection of phenols and carboxylic acids. It undergoes condensation reactions with aldehydes in the presence of SnCl2 or SmI3 to afford α,β-unsaturated ketones. It is also useful in the esterification of carboxylic acids.

General Description

A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 0.5 μM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM.

Biochem/physiol Actions

Cell permeable: yes

Purification Methods

Crystallise the bromide from EtOH (ca 8mL/g). [Beilstein 7 IV 652.]

2,4'-Dibromoacetophenone Preparation Products And Raw materials

Raw materials

4'-Bromoacetophenone

Preparation Products

2-(4-BROMOBENZOYL)-1-BENZOFURAN-5-CARBALDEHYDE 3-(4-BROMOPHENYL)ISOXAZOL-5-AMINE
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2,4'-Dibromoacetophenone Suppliers

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View Lastest Price from 2,4'-Dibromoacetophenone manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
2,4'-Dibromoacetophenone 99-73-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-08-30
Shaanxi Haibo Biotechnology Co., Ltd
Product
2,4'-Dibromoacetophenone 99-73-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-31
Hebei Mojin Biotechnology Co., Ltd
Product
2,4'-Dibromoacetophenone 99-73-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-31

99-73-0, 2,4'-DibromoacetophenoneRelated Search:

3-Nitroacetophenone 4-Bromophenethyl alcohol Bromoacetyl bromide 4-Nitroacetophenone 4-Bromoanisole L-PICEIN Ethidium bromide Clidinium bromide 4'-Methoxyacetophenone Sodium bromate Acetophenone 4-Bromobenzotrifluoride 4-Bromotoluene 4-Bromobenzaldehyde 2',4'-Difluoroacetophenone 1,4-Dibromobenzene Acetyl bromide 3-Aminoacetophenone

  • P-BROMOPHENACYL BROMIDE
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  • 2-Bromo-4'-bromoacetophenone
  • 4-Bromophenacyl Bromide 99% Ar
  • GSK-3β Inhibitor VII - CAS 99-73-0 - Calbiochem
  • a,4-Dibromoacetophenone
  • 4-BROMOPHENACYL BROMIDE, FOR FLUOR-ESCEN CE
  • BromophenacylBromide
  • 4-BromophenacylBromide98%
  • 4-Bromophenacyl Bromide 98%
  • Ethanone, 2-bromo-1-(4-bromophenyl)-
  • à-4-dibromoacetophenone
  • ω.ρ-Dibromoacetoplenone
  • 2,4'-DibroMo-acetophenone &gt
  • 2,4- twobroMoacetophenone
  • 2,4'-DibroMoacetophenone, 97+%
  • 99-73-0
  • 2,4'-Dibromoacetophenone puriss., >=98.5% (HPLC)
  • ALPHA,4'-DIBROMOACETOPHENONE
  • ALPHA-4-DIBROMOACETOPHENONE
  • ALPHA,P-DIBROMOACETOPHENONE
  • AKOS BBS-00000865
  • 4'-BROMOPHENACYL BROMIDE
  • 4-BROMOPHENACYL BROMIDE
  • 4,OMEGA-DIBROMOACETOPHENONE
  • 2-BROMO-1-(4-BROMOPHENYL)ETHANONE
  • 2-BROMO-1-(4-BROMOPHENYL)ETHAN-1-ONE
  • A,P-DIBROMOACETOPHENONE
  • GSK-3BETA INHIBITOR VII
  • DIBROMOACETOPHENONE-2,4
  • Platinum oxide monohydrate (IV)
  • 4-Bromophenacyl Bromide &gt
  • 4-Bromophenacyl Bromide [for HPLC Labeling]&gt
  • 2,4'-DIBROMOACETOPHENONE FOR SYNTHESIS
  • 2,4′-dibromoacetophenone 2
  • 2,4'-Dibromoacetophenone
  • 99-73-0
  • BrCH2COC6H4Br