ChemicalBook > CAS DataBase List > Dimethyl malate

Dimethyl malate

Product Name
Dimethyl malate
CAS No.
617-55-0
Chemical Name
Dimethyl malate
Synonyms
DIMETHYL L-MALATE;diMethyl 2-hydroxysuccinate;Dimethyl malate;L-DIMETHYLMALATE;DIMETHYL L-(-)-MALATE;DIMETHYL (S)-(-)-MALATE;(S)-(-)-DIMETHYL MALATE;Dimethyle(S)-(-)-malate;DimethylL-(-)-Malate>Dimethyl L-malate (LDMM)
CBNumber
CB4239462
Molecular Formula
C6H10O5
Formula Weight
162.14
MOL File
617-55-0.mol
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Dimethyl malate Property

Boiling point:
104-108 °C1 mm Hg(lit.)
Density 
1.232 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.441
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
Chloroform (Sparingly), Methanol (Slightly)
pka
11.72±0.20(Predicted)
form 
Liquid
color 
Colorless to pale yellow
optical activity
[α]20/D 6.5°, neat
BRN 
1724363
InChIKey
YSEKNCXYRGKTBJ-BYPYZUCNSA-N
LogP
-0.830 (est)
CAS DataBase Reference
617-55-0(CAS DataBase Reference)
EPA Substance Registry System
Dimethyl L-malate (617-55-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-43-41-10
Safety Statements 
26-36-43-37/39-24
RIDADR 
1993
WGK Germany 
3
F 
10-21
HazardClass 
3
PackingGroup 
Ⅲ
HS Code 
29181990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
374318
Product name
Dimethyl (S)-(?)-malate
Purity
98%
Packaging
5g
Price
$81.2
Updated
2025/07/31
Sigma-Aldrich
Product number
374318
Product name
Dimethyl (S)-(?)-malate
Purity
98%
Packaging
25g
Price
$101
Updated
2025/07/31
TCI Chemical
Product number
M1343
Product name
Dimethyl L-(-)-Malate
Purity
>98.0%(GC)
Packaging
5g
Price
$19
Updated
2025/07/31
TCI Chemical
Product number
M1343
Product name
Dimethyl L-(-)-Malate
Purity
>98.0%(GC)
Packaging
25g
Price
$51
Updated
2025/07/31
TRC
Product number
D474575
Product name
Dimethyl (S)-(?)-malate
Packaging
2g
Price
$65
Updated
2021/12/16
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Dimethyl malate Chemical Properties,Usage,Production

Chemical Properties

Colourless Oil

Uses

This chiral synthon has been used to prepare cytochrome P450 metabolites of arachidonic acid, and cyclic sulfolanes with HIV-1 protease inhibition potential.

Synthesis

67-56-1

97-67-6

617-55-0

Thionyl chloride (117 g, 0.98 mol) was slowly added dropwise to a methanol (400 mL) solution of L-malic acid (59.9 g, 0.45 mol) in an ice-water bath. After the dropwise addition, the reaction mixture was stirred at room temperature (25 °C) for overnight reaction. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio ethyl acetate: methanol = 10:1). After completion of the reaction, the solvent was evaporated under reduced pressure. Saturated sodium bicarbonate solution (200 mL) was added to the residue and the aqueous phase was extracted with ethyl acetate (3 x 150 mL). The organic phases were combined, washed sequentially with water (3×80 mL), saturated saline (3×80 mL) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give dimethyl L-malate as a light yellow oil in 98% yield (71.5 g, 0.44 mol).

References

[1] Bioorganic and medicinal chemistry, 2002, vol. 10, # 6, p. 1829 - 1839
[2] Organic Letters, 2009, vol. 11, # 5, p. 1135 - 1137
[3] RSC Advances, 2016, vol. 6, # 27, p. 22737 - 22748
[4] Tetrahedron, 1992, vol. 48, # 30, p. 6325 - 6334
[5] Tetrahedron Letters, 2003, vol. 44, # 16, p. 3391 - 3395

Dimethyl malate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dimethyl malate manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Dimethyl malate 617-55-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-17
Honest Joy Holdings Limited
Product
L-(-)-Malic acid dimethyl ester 617-55-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99.5%
Supply Ability
100 tons
Release date
2022-02-20
Zhuozhou Wenxi import and Export Co., Ltd
Product
Dimethyl malate 617-55-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

617-55-0, Dimethyl malateRelated Search:

Dimethyl sebacate Dimethyl phthalate Dimethyl sulfate Dimethyl carbonate Dimethyl oxalate Dimethyl fumarate Dimethyl ether Dacthal ETHANE Malic acid Dimethyl sulfide Dimethyl sulfoxide N,N-Dimethylformamide Dimethyl malate Triethyl citrate (-)-Dimethyl D-tartrate CITRIC ACID TRIALLYL ESTER Acetyl tributyl citrate

  • L-(-)-APPLE ACID DIMETHYL ESTER
  • L-DIMETHYLMALATE
  • DIMETHYL (S)-(-)-MALATE
  • DIMETHYL (S)-2-HYDROXYSUCCINATE
  • DIMETHYL L-(-)-MALATE
  • DIMETHYL L-MALATE
  • L-(-)-MALIC ACID DIMETHYL ESTER
  • L-MALIC ACID DIMETHYL ESTER
  • (S)-DIMETHYL HYDROXYBUTANEDIOATE
  • (S)-DIMETHYL HYDROXYSUCCINATE
  • (S)-(-)-DIMETHYL MALATE
  • Dimethyl L-malate (LDMM)
  • 2-Hydroxybutanedioic acid dimethyl ester
  • Dimethyl malate
  • Dimethyl (S)-2-hydroxysuccinate, Dimethyl L-malate
  • (2S)-2-Hydroxybutanedioic acid dimethyl ester
  • (2S)-2-Hydroxysuccinic acid dimethyl ester
  • (S)-2-Hydroxybutanedioic acid dimethyl ester
  • (S)-Hydroxysuccinic acid dimethyl ester
  • (2S)-2-Hydroxy-butanedioic Acid 1,4-DiMethyl Ester
  • (2S)-Hydroxysuccinic Acid DiMethyl Ester
  • L-(-)-Apple Acid Dimethyl Ester L-(-)-Malic Acid Dimethyl Ester
  • (S)-(-)-DIMETHYL MALATE FOR SYNTHESIS
  • (S)-DiMethyl 2-hydroxysuccinate
  • diMethyl 2-hydroxysuccinate
  • DiMethyl (S)-(-)-Malate 98%
  • Dimethyle(S)-(-)-malate
  • DimethylL-(-)-Malate&gt
  • Butanedioic acid, 2-hydroxy-, 1,4-dimethyl ester, (2S)-
  • dimethyl (2S)-2-hydroxysuccinate
  • Dimethyl (<i>S</i>)-(?)-malate
  • 617-55-0
  • CH3O2CCH2CHOHCO2CH3
  • ALCOHOL
  • Asymmetric Synthesis
  • Esters
  • Organic Building Blocks
  • Esters (Chiral)
  • Chiral Building Blocks
  • chiral
  • Chiral Reagents
  • Chiral Building Blocks
  • Esters (Chiral)
  • Synthetic Organic Chemistry