Dimethyl malate
- Product Name
- Dimethyl malate
- CAS No.
- 617-55-0
- Chemical Name
- Dimethyl malate
- Synonyms
- DIMETHYL L-MALATE;diMethyl 2-hydroxysuccinate;Dimethyl malate;L-DIMETHYLMALATE;DIMETHYL L-(-)-MALATE;DIMETHYL (S)-(-)-MALATE;(S)-(-)-DIMETHYL MALATE;Dimethyle(S)-(-)-malate;DimethylL-(-)-Malate>Dimethyl L-malate (LDMM)
- CBNumber
- CB4239462
- Molecular Formula
- C6H10O5
- Formula Weight
- 162.14
- MOL File
- 617-55-0.mol
Dimethyl malate Property
- Boiling point:
- 104-108 °C1 mm Hg(lit.)
- Density
- 1.232 g/mL at 20 °C(lit.)
- refractive index
- n20/D 1.441
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- pka
- 11.72±0.20(Predicted)
- form
- Liquid
- color
- Colorless to pale yellow
- optical activity
- [α]20/D 6.5°, neat
- BRN
- 1724363
- InChIKey
- YSEKNCXYRGKTBJ-BYPYZUCNSA-N
- LogP
- -0.830 (est)
- CAS DataBase Reference
- 617-55-0(CAS DataBase Reference)
- EPA Substance Registry System
- Dimethyl L-malate (617-55-0)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-43-41-10
- Safety Statements
- 26-36-43-37/39-24
- RIDADR
- 1993
- WGK Germany
- 3
- F
- 10-21
- HazardClass
- 3
- PackingGroup
- Ⅲ
- HS Code
- 29181990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H317May cause an allergic skin reaction
H318Causes serious eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 374318
- Product name
- Dimethyl (S)-(?)-malate
- Purity
- 98%
- Packaging
- 5g
- Price
- $81.2
- Updated
- 2025/07/31
- Product number
- 374318
- Product name
- Dimethyl (S)-(?)-malate
- Purity
- 98%
- Packaging
- 25g
- Price
- $101
- Updated
- 2025/07/31
- Product number
- M1343
- Product name
- Dimethyl L-(-)-Malate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $19
- Updated
- 2025/07/31
- Product number
- M1343
- Product name
- Dimethyl L-(-)-Malate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $51
- Updated
- 2025/07/31
- Product number
- D474575
- Product name
- Dimethyl (S)-(?)-malate
- Packaging
- 2g
- Price
- $65
- Updated
- 2021/12/16
Dimethyl malate Chemical Properties,Usage,Production
Chemical Properties
Colourless Oil
Uses
This chiral synthon has been used to prepare cytochrome P450 metabolites of arachidonic acid, and cyclic sulfolanes with HIV-1 protease inhibition potential.
Synthesis
67-56-1
97-67-6
617-55-0
Thionyl chloride (117 g, 0.98 mol) was slowly added dropwise to a methanol (400 mL) solution of L-malic acid (59.9 g, 0.45 mol) in an ice-water bath. After the dropwise addition, the reaction mixture was stirred at room temperature (25 °C) for overnight reaction. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio ethyl acetate: methanol = 10:1). After completion of the reaction, the solvent was evaporated under reduced pressure. Saturated sodium bicarbonate solution (200 mL) was added to the residue and the aqueous phase was extracted with ethyl acetate (3 x 150 mL). The organic phases were combined, washed sequentially with water (3×80 mL), saturated saline (3×80 mL) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give dimethyl L-malate as a light yellow oil in 98% yield (71.5 g, 0.44 mol).
References
[1] Bioorganic and medicinal chemistry, 2002, vol. 10, # 6, p. 1829 - 1839
[2] Organic Letters, 2009, vol. 11, # 5, p. 1135 - 1137
[3] RSC Advances, 2016, vol. 6, # 27, p. 22737 - 22748
[4] Tetrahedron, 1992, vol. 48, # 30, p. 6325 - 6334
[5] Tetrahedron Letters, 2003, vol. 44, # 16, p. 3391 - 3395
Dimethyl malate Preparation Products And Raw materials
Raw materials
Preparation Products
Dimethyl malate Suppliers
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- Country
- Switzerland
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- 6896
- Advantage
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View Lastest Price from Dimethyl malate manufacturers
- Product
- Dimethyl malate 617-55-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- L-(-)-Malic acid dimethyl ester 617-55-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.5%
- Supply Ability
- 100 tons
- Release date
- 2022-02-20
- Product
- Dimethyl malate 617-55-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11