ChemicalBook > CAS DataBase List > 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER

2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER

Product Name: 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER
CAS No.: 944401-58-5
Chemical Name: 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER
Synonyms: EOS-60712;-4-(trifluoromethyl);2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER;2-Amino-4-trifluoromethylpyrimidine-5-boronic acid pinacol ester;2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER ISO 9001：2015 REACH;5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-pyrimidinamine;2-Pyrimidinamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-;5-(4,4,5,5-tetramethyl(1,3,2-dioxaborolan-2-yl))-4-(trifluoromethyl)pyrimidine-2-ylamine;[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyrimidin-2-yl]amine
CBNumber: CB42453060
Molecular Formula: C11H15BF3N3O2
Formula Weight: 289.06
MOL File: 944401-58-5.mol

Less

2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Property

Boiling point:: 403.8±55.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.80±0.10(Predicted)
Appearance: White to off-white Solid

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

TRC

Product number: A631360
Product name: 2-Amino-4-trifluoropyrimidine-5-boronicAcidPinacolEster
Packaging: 100mg
Price: $335
Updated: 2021/12/16

TRC

Product number: A631360
Product name: 2-Amino-4-trifluoropyrimidine-5-boronicAcidPinacolEster
Packaging: 500mg
Price: $1060
Updated: 2021/12/16

Usbiological

Product number: 259855
Product name: 2-Amino-4-trifluoromethylpyrimidine-5-boronic acid pinacol ester
Packaging: 2g
Price: $1070
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA29199
Product name: 2-Amino-4-trifluoromethylpyrimidine-5-boronic acid pinacol ester
Packaging: 10g
Price: $1140
Updated: 2021/12/16

AK Scientific

Product number: W9682
Product name: 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyrimidin-2-amine
Packaging: 250mg
Price: $227
Updated: 2021/12/16

Less

2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Chemical Properties,Usage,Production

Synthesis

935534-47-7

73183-34-3

944401-58-5

4-Trifluoromethyl-5-bromo-2-pyrimidinamine (16.2 g, 66.3 mmol), pinacol ester of bisboronic acid (18.5 g, 72.9 mmol), and potassium acetate (19.5 g, 199 mmol) were suspended in dioxane (300 mL) under argon protection. To this suspension was added PdCl2(dppf)CH2Cl2 adduct (2.4 g, 2.98 mmol) and the mixture was stirred at 115 °C for 4 hours. After completion of the reaction, the mixture was cooled to 50 °C and treated with ethyl acetate. The resulting suspension was filtered through Hyflo and washed with ethyl acetate. The combined filtrates were concentrated and the residue was suspended in 2N NaOH solution and stirred at room temperature for 5 minutes. Subsequently, ether and water were added and the two-phase mixture formed was filtered through Hyflo. The two phases of the filtrate were separated and the pH of the aqueous phase was adjusted to 5-6 with 4N HCl and then extracted with ethyl acetate. The organic layer was washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was ground in ether and hexane and filtered to give pinacol ester of 2-amino-4-trifluoromethylpyrimidine-5-boronic acid (8.33 g, 42% yield). Retention time (tR): 1.00 min (LC-MS 1); ESI-MS: 290.3 [M + H]+ (LC-MS 1).

References

[1] Patent: US2013/225574, 2013, A1. Location in patent: Paragraph 0504; 0505
[2] Patent: US2014/135330, 2014, A1. Location in patent: Paragraph 0218

2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER Suppliers

China 54 India 1 United Kingdom 1 United States 6 Global 62

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 15136
Advantage: 55

Changsha Luxing Bio-Chem Technology Co., Ltd.

Tel: 0731-88827538 15873153880
Fax: 0731-88827238
Email: luxingbc@126.com
Country: China
ProdList: 2002
Advantage: 65

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-58362220 0086-15250997978
Fax: 025-58362220
Email: sale@njxizebio.com
Country: China
ProdList: 4855
Advantage: 55

SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 0512-0512-52358471 17715136450
Fax: 05125235 6881
Email: sales@shiyabiopharm.com
Country: China
ProdList: 12127
Advantage: 58

Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.

Tel: 027-65388397 18164111589
Fax: 027-65388397
Email: 3321478047@qq.com
Country: China
ProdList: 2007
Advantage: 55

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6355
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Wuxi KaideRui Pharmaceutical Technology Co., Ltd

Tel: 19906241957
Fax: -
Email: 1557216087@qq.com
Country: China
ProdList: 1837
Advantage: 55

Jiaxing Deyi Chemical Co., Ltd.

Tel: 86-0573-85866609 13325730825
Fax: 0573-85866609
Email: 945717149@qq.com
Country: China
ProdList: 8596
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

Chengdu Feibai Pharmaceutical Co., Ltd.

Tel: 028-84641798 18782128315
Email: 3302391190@qq.com
Country: China
ProdList: 9799
Advantage: 55

Shanghai zhigan biotechnology co., LTD

Tel
Email: zhiqianbio@126.com
Country: China
ProdList: 19778
Advantage: 58

Allfluoro pharmaceutical co. ltd.

Tel: +86-400-0216110 +86-15958047586
Fax: 0086-21-33275002
Email: sales@allfluoro.com
Country: China
ProdList: 11385
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

CD Chemical Group Limited

Tel: +8615986615575
Fax: 0086-13651442114
Email: info@codchem.com
Country: China
ProdList: 20342
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 8025
Advantage: 58

Win-Win chemical CO., Limited

Tel: +86-0086-577-64498589 +86-15355981851
Fax: 0086-577-56994596
Email: sales@win-winchemical.com
Country: China
ProdList: 14359
Advantage: 58

Xi'an Minze Pharmaceutical Technology Co., Ltd

Tel: 13981836672
Email: 2560370848@qq.com
Country: China
ProdList: 2807
Advantage: 58

Hubei xin bonus chemical co. LTD

Tel: 86-13657291602
Fax: 027-59338440
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 22963
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

Wuxi Donghe Pharmaceutical Technology Co., Ltd.

Tel: 63313187 15358055255
Fax: QQ：63313187
Email: 63313187@qq.com
Country: China
ProdList: 1984
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Fuxin Pharmaceutical

Tel: +86-021-021-50872116 +8613122107989
Email: contact@fuxinpharm.com
Country: China
ProdList: 10000
Advantage: 58

Guangzhou Yuheng Pharmaceutical Technology Co., Ltd

Tel: +8613580539051
Email: joe@yuhengpharm.com
Country: CHINA
ProdList: 21142
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-029-81024372 17792795018
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10003
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Email: 2853979819@qq.com
Country: China
ProdList: 9998
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Qi Qi hang Biotechnology Co., Ltd.

Tel: 15870833005
Email: 2232044025@qq.com
Country: China
ProdList: 8206
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Hubei Hannuo Pharmaceutical Technology Co., Ltd

Tel: 18662190603
Email: 437347250@qq.com
Country: China
ProdList: 7325
Advantage: 58

Shanghai Lingfu Pharmaceutical Research Co. LTD

Tel: +86(21)5895 0110 19945755304
Email: sales@chemany.com
Country: China
ProdList: 9984
Advantage: 58

Heze Aiding Pharmaceutical Co., Ltd

Tel: 17661365138
Email: 2845578351@qq.com
Country: China
ProdList: 7115
Advantage: 58

ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054;
Email: trendseenbio@gmail.com
Country: China
ProdList: 9069
Advantage: 58

Zhuhai Aobokai Biomedical Technology Co., Ltd.

Tel: 400-0628126 18736790110;
Email: sales-team@aobchem.com.cn
Country: China
ProdList: 50000
Advantage: 58

Huanuo Pharmaceutical Technology (Guangxi) Co., Ltd

Tel: 13005928603
Email: 211017228@qq.com
Country: China
ProdList: 8277
Advantage: 58

ChemShuttle, Inc.

Tel: 0510-83588313-811 18800520310
Email: sales@chemshuttle.com
Country: China
ProdList: 4998
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Email: sales@coreychem.com
Country: China
ProdList: 29847
Advantage: 58

DAYANG CHEM (HANGZHOU) CO.,LTD

Tel: +86-88938639 +86-17705817739
Email: info@dycnchem.com
Country: China
ProdList: 53899
Advantage: 58

Less

View Lastest Price from 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER 944401-58-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Career Henan Chemical Co

Product: 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER 944401-58-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg; 10kg; 100kg
Release date: 2019-08-30

944401-58-5, 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTERRelated Search:

2-Amino-3-bromo-6-chloropyrazine 2-AMino-6-broMo-5,6-dihydro-7(4H)-benzothiazolone L-Alanyl-L-Glutamine impurity 25 2-AMino-4-chloro-6-MethylpyriMidine-5-carbonitrile OSU-03012 1H-Imidazole-4-carboxylicacid,2-amino-,ethylester(9CI) 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)aniline 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)aniline 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethoxy)aniline 2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER 2-Aminopyrimidine-5-boronic Acid Pinacol Ester

2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER

2-Amino-4-trifluoromethylpyrimidine-5-boronic acid pinacol ester

[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyrimidin-2-yl]amine

EOS-60712

5-(4,4,5,5-tetramethyl(1,3,2-dioxaborolan-2-yl))-4-(trifluoromethyl)pyrimidine-2-ylamine

2-Pyrimidinamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-

2-AMINO-4-TRIFLUOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER ISO 9001：2015 REACH

-4-(trifluoromethyl)

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-pyrimidinamine

944401-58-5

C11H15BF3N3O2

C10H16BF3N3O3