PD 0325901

ChemicalBook > CAS DataBase List > PD 0325901

Product Name: PD 0325901
CAS No.: 391210-10-9
Chemical Name: PD 0325901
Synonyms: Mirdametinib;PD325901;Mirdametinib (PD0325901);CS-52;PD 032590;PD 0325901;PD-0235901;PD0325901, >=98%;MEK1/2 Inhibitor III;PD0325901 (PD325901)
CBNumber: CB42464161
Molecular Formula: C16H14F3IN2O4
Formula Weight: 482.19
MOL File: 391210-10-9.mol

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PD 0325901 Property

Melting point:: 112-114°C
Density: 1.817±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
form: White to off-white solid
pka: 13.45±0.20(Predicted)
color: white to off-white
optical activity: [α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey: SUDAHWBOROXANE-SECBINFHSA-N

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Safety

Hazard Codes: T,N
Risk Statements: 25-48-50
Safety Statements: 22-36/37/39-61
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H373May cause damage to organs through prolonged or repeated exposure

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 444968
Product name: InSolution? MEK1/2 Inhibitor III, PD0325901
Packaging: 5mg
Price: $230
Updated: 2024/03/01

Sigma-Aldrich

Product number: 444966
Product name: MEK1/2 Inhibitor III
Packaging: 5mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 13034
Product name: PD 0325901
Purity: ≥98%
Packaging: 5mg
Price: $43
Updated: 2024/03/01

Cayman Chemical

Product number: 13034
Product name: PD 0325901
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2023/06/20

Sigma-Aldrich

Product number: PZ0162
Product name: PD 0325901
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $155
Updated: 2024/03/01

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PD 0325901 Chemical Properties,Usage,Production

Description

PD 325901 (391210-10-9) is a selective non-ATP competitive MEK inhibitor (IC50 = 0.33 nM).1 Inhibits growth and/or proliferation of a variety of cancer cells.2 Enhances self-renewal of embryonic stem cells.3 In combination with vitamin C, synergistically induces hypomethylation of mouse embryonic stem cells.4 In combination with CHIR-99021 and A83-01 induces generation of ground state iPS cells from human and rat somatic cells.5

Chemical Properties

White to Off-White Solid

Uses

PD 0325901 has been used as an inhibitor in extracellular signal-regulated kinase (ERK) inhibition assay in primed induced pluripotent stem cells, RKO colorectal cancer cell line and human embryonic stem cells(hESCs).

Uses

The mitogenic extracellular kinase 1/2 (MEK1/2) inhibitor

Definition

ChEBI: A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer).

Biochem/physiol Actions

PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.

storage

-20°C

References

1) Sebolt-Leopold et al. (2004), The biological profile of PD0325901: A second generation analog of CI-1040 with improved pharmaceutical potential; Proc. Amer. Assoc. Cancer Res., 45 925 2) Ciuffreda et al. (2009), Growth-inhibitor and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations; Neoplasia, 11 720 3) Ai et al. (2016), Maintenance of Self-Renewal and Pluripotency in J1 Mouse Embryonic Stem Cells through Regulating Transcription Factor and MicroRNA Expression Induced by PD0325901; Stem Cells Int., 2016 1792573 4) Li et al. (2016), MEK inhibitor PD0325901 and vitamin C synergistically induce hypomethylation of mouse embryonic stem cells; Oncotarget, 7 39730 5) Li et al. (2009), Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors; Cell Stem Cell, 4 16

PD 0325901 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PD 0325901 manufacturers

Career Henan Chemical Co

Product: PD 0325901 391210-10-9
Price: US $3.00/KG
Min. Order: 3KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-08-26

391210-10-9, PD 0325901Related Search:

PD 123319 ditrifluoroacetate PD 166285 PD173955 PD 166793 PD 98059 PD184352 PD318088 PRND Y27632 (hydrochloride) Selumetinib MK-2206 2HCl SB 431542 Trametinib CHIR-99021 PD 166866 PD 173074 2-Fluoro-4-iodoaniline PD 0325901

N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-BENZAMIDE

PD 0325901

(R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide

PD-0235901

N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]be

PD325901

N-[(R)-2,3 -Dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylaMino)-benzaMide

N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide PD0325901

PD 0325901 N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide

PD0325901, >=98%

MEK1/2 Inhibitor III

InSolution? MEK1/2 Inhibitor III, PD0325901

(R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide 98%

PD 0325901; PD325901; PD-0325901

PD0325901(Mirdametinib)

PD0325901 (PD325901)

CS-52

InSolution MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem

MEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem

(870474-62-7) pd 0325901

Mirdametinib

PD 0325901 USP/EP/BP

PD-325901 DISCONTINUED

Mirdametinib (PD0325901)

MEK1/2 Inhibitor III PD-0325901 PD0325901 Mirdametinib MEK inhibitor

PD 032590

PD-0325901,MAPKK,Mitogen-activated protein kinase kinase,PD-325901,Apoptosis,PD 0325901,MEK,Autophagy,Mirdametinib,inhibit,PD 325901,MAP2K,Inhibitor

391210-10-9

301210-10-9

C16H14F3IN2O4

MAPK

Inhibitor

Inhibitors

Aromatics

Chiral Reagents

Intermediates & Fine Chemicals

Pharmaceuticals

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