1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE

Product Name: 1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE
CAS No.: 918524-63-7
Chemical Name: 1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE
Synonyms: Pinacol 2-(4-methylpiperazino)-5-pyridylboronate;(S)-1-[(rp)-2-(dicyclohexylphosphino)ferrocenylethyldi-;2-(4-Methylpiperazino)pyridine-5-boronic acid pinacol ester;2-(N-Methylpiperazin-1-yl)pyridine-5-boronic acid pinacol ester;6-(4-Methyl-1-piperazinyl)pyridine-3-boronic Acid Pinacol Ester;1-Methyl-4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)p...;6-(4-Methylpiperazin-1-yl)pyridin-3-ylboronic acid pinacol ester;6-(4-Methylpiperazin-1-yl)pyridine-3-boronic acid, pinacol ester 98%;[6-(4-Methylpiperazin-1-yl)pyridin-3-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;1-Methyl-4-5-(4,4,5,5-tetramethyl-1,3,2-dioxaboralan-2-yl)-pyridin-2-ylpiperazine
CBNumber: CB42464303
Molecular Formula: C16H26BN3O2
Formula Weight: 303.21
MOL File: 918524-63-7.mol

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1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE Property

Melting point:: 125 °C
Boiling point:: 435.2±45.0 °C(Predicted)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 8.41±0.31(Predicted)
form: solid
color: white
InChI: InChI=1S/C16H26BN3O2/c1-15(2)16(3,4)22-17(21-15)13-6-7-14(18-12-13)20-10-8-19(5)9-11-20/h6-7,12H,8-11H2,1-5H3
InChIKey: KVQXFNGVIIPCSX-UHFFFAOYSA-N
SMILES: N1(C)CCN(C2=NC=C(B3OC(C)(C)C(C)(C)O3)C=C2)CC1

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Safety

Hazard Codes: C
Risk Statements: 22-34
Safety Statements: 22-26-36/37/39-45
RIDADR: UN2811
TSCA: No
HazardClass: 6.1
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3116
Product name: 1-Methyl-4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine
Purity: >98.0%(GC)(T)
Packaging: 200mg
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: M3116
Product name: 1-Methyl-4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $151
Updated: 2025/07/31

TRC

Product number: M329005
Product name: 1-Methyl-4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridin-2-yl]piperazine
Packaging: 100mg
Price: $165
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H60-1-P6
Product name: 6-(4-Methylpiperazin-1-yl)pyridine-3-boronic acid, pinacol ester
Packaging: 1g
Price: $176
Updated: 2021/12/16

Matrix Scientific

Product number: 092667
Product name: 1-Methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxa-borolan-2-yl)pyridin-2-yl)piperazine
Purity: 95+%
Packaging: 250mg
Price: $189
Updated: 2021/12/16

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1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE Chemical Properties,Usage,Production

Uses

1-Methyl-4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridin-2-yl]piperazine is used to prepare yrazolopyridine and indazoles as histone lysine methyltransferase EZH2 inhibitors. It is also used to synthesize tetrahydropyrido pyrazines as anaplastic lymphoma kinase inhibitors.

Synthesis

73183-34-3

364794-58-1

918524-63-7

Using 1-(5-bromopyridin-2-yl)-4-methylpiperazine (1.5 g, 5.9 mmol), bis(pinacolato)diboron (1.6 g, 6.5 mmol), potassium acetate (1.8 g, 18 mmol), and Pd(dppf)2Cl2[CH2Cl2] (0.73 g, 0.89 mmol) as raw materials, the mixture was dissolved under nitrogen protection in DMSO (20 mL) and the reaction was stirred at 80 °C overnight. After completion of the reaction, the mixture was diluted with water and extracted with ethyl acetate (EA). The organic phases were combined and concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, v/v=3 to pure ethyl acetate) to afford the target product, 6-(4-methyl-1-piperazinyl)pyridine-3-boronic acid pinacol ester (1.0 g, 56% yield) as a brown solid. Mass spectrometry (MS) analysis showed m/z 304 (M+H)+.

References

[1] Patent: WO2016/73956, 2016, A1. Location in patent: Paragraph 00361
[2] Patent: EP2719697, 2014, A1. Location in patent: Paragraph 0169; 0172; 0173

1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE Suppliers

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View Lastest Price from 1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE 918524-63-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

Henan Fengda Chemical Co., Ltd

Product: 2-(4-Methyl-piperazin-1-yl)pyridine-5-boronic acid pinacol ester 918524-63-7
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-31

Puyang Huicheng Electronic Materials Co., Ltd.

Product: 1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE 918524-63-7
Price: US $100000.00/g
Min. Order: 10g
Purity: 99%(HPLC)
Supply Ability: 20 tons
Release date: 2020-06-05

918524-63-7, 1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINERelated Search:

6-(4-MorpholinylMethyl)pyridine-3-boronic acid pinacol ester Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate 2-(BENZYLAMINO)PYRIDINE-5-BORONIC ACID PINACOL ESTER 6-(CYCLOHEXYLAMINO)PYRIDINE-3-BORONIC ACID PINACOL ESTER 6-(4-FLUOROPHENYL)PYRIDINE-3-BORONIC ACID PINACOL ESTER TERT-BUTYL N-METHYL-N-[5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDIN-2-YL]CARBAMATE 2-(4-METHYLBENZYLAMINO)PYRIDINE-5-BORONIC ACID PINACOL ESTER 4-[5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDIN-2-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL N-METHYL-N-[3-METHYL-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDIN-2-YL]CARBAMATE 2-(CYCLOPROPYLMETHOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE-2-CARBOXYLIC ACID DIETHYLAMIDE N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide 2-CYANOPYRIDINE-4-BORONIC ACID PINACOL ESTER 6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER 1-(5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-2-YL)PIPERAZINE 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)chroman, 97% 6-Dimethylaminopyridine-3-boronic acid pinacol ester 2-METHYLSULFANYL-5-(4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLAN-2-YL)PYRIDINE

1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE

1-methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine HCl

2-(4-Methylpiperazino)pyridine-5-boronic acid pinacol ester

1-Methyl-4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine, 2-(4-Methylpiperazin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Piperazine, 1-Methyl-4-[5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-

6-(4-Methylpiperazin-1-yl)pyridin-3-ylboronic acid pinacol ester

6-(4-Methyl-1-piperazinyl)pyridine-3-boronic Acid Pinacol Ester

2-(4-Methylpiperazino)pyridine-5-boronic acid pinacol ester 2-(4-Methylpiperazin-1-yl)pyridine-5-boronic acid pinacol ester

1-Methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine hydrochloride

Pinacol 2-(4-methylpiperazino)-5-pyridylboronate

2-(N-Methylpiperazin-1-yl)pyridine-5-boronic acid pinacol ester

6-(4-Methylpiperazin-1-yl)pyridine-3-boronic acid, pinacol ester 98%

[6-(4-Methylpiperazin-1-yl)pyridin-3-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1-Methyl-4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)p...

1-Methyl-4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]piperazine

1-Methyl-4-5-(4,4,5,5-tetramethyl-1,3,2-dioxaboralan-2-yl)-pyridin-2-ylpiperazine

(S)-1-[(rp)-2-(dicyclohexylphosphino)ferrocenylethyldi-

918524-63-7