6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol

Product Name: 6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol
CAS No.: 7400-06-8
Chemical Name: 6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol
Synonyms: NSC 59250;Tofacitinib Impurity 203;6-Amino-5-(2,2-diethoxyethyl);6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol;6-amino-5-(2,2-diethoxyethyl)-1H-pyrimidin-4-one;6-AMino-5-(2,2-diethoxyethyl)-4(3H)-pyriMidinone;6-aMino-5-(2,2-diethoxyethyl)pyriMidin-4(3H)-one;4-amino-6-hydroxy-5-(2,2-diethoxyethyl)pyrimidine;4(3H)-PyriMidinone, 6-aMino-5-(2,2-diethoxyethyl)-;6-aMino-5-(2,2-diethoxyethyl)-1,4-dihydropyriMidin-4- one
CBNumber: CB42470171
Molecular Formula: C10H17N3O3
Formula Weight: 227.26
MOL File: 7400-06-8.mol

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6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol Property

Melting point:: 193-196°C
Boiling point:: 336.0±52.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Methanol (Slightly)
form: Solid
pka: 10.08±0.50(Predicted)
color: Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A604850
Product name: 6-Amino-5(2,2-diethoxyethyl)-4-hydroxyPyrimidine
Packaging: 2g
Price: $545
Updated: 2021/12/16

Matrix Scientific

Product number: 093053
Product name: 6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol
Purity: 95+%
Packaging: 250mg
Price: $567
Updated: 2021/12/16

Matrix Scientific

Product number: 093053
Product name: 6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol
Purity: 95+%
Packaging: 1g
Price: $1260
Updated: 2021/12/16

ChemScene

Product number: CS-M3534
Product name: 4(3H)-Pyrimidinone,6-amino-5-(2,2-diethoxyethyl)-
Purity: 97.78%
Packaging: 1g
Price: $268
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17591
Product name: 6-Amino-5(2,2-diethoxyethyl)-4-hydroxy pyrimidine
Packaging: 500mg
Price: $300
Updated: 2021/12/16

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6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol Chemical Properties,Usage,Production

Chemical Properties

White Crystals With a Greenish Cast

Synthesis

7400-05-7

7400-06-8

Step i: 6-Amino-5-(2,2-diethoxyethyl)-2-mercapto-4-hydroxypyrimidine (11.6 mmol) [for preparation, see Davoll, J., J. Chem. Soc., 1960, pp131-138] was dissolved in a solvent mixture of water (150 mL) and aqueous ammonia solution (9 mL) and heated to 90°C. Raney Nickel suspension was added to the reaction mixture in batches (2-3 mL at a time) until TLC and LC/MS analysis showed that the reaction was complete. The reaction mixture was cooled to room temperature, filtered through a diatomaceous earth pad and the filter cake was washed with water (2 x 25 mL). The combined aqueous filtrates were freeze-dried to afford 6-amino-5-(2,2-diethoxyethyl)-4-hydroxypyrimidine as an off-white powder in a yield of 2.23 g (85%).LC/MS: RT = 1.37 min; m/z = 182 [M-EtOH + H]+ . Total run time was 3.75 min.1H NMR (DMSO-d6): δ 1.07 (t, 6H); 3.40 (m, 2H); 3.59 (m, 2H); 4.56 (t, 1H); 6.07 (br s, 2H); 7.70 (s, 1H); 11.43 (br s, 1H).

References

[1] Patent: WO2007/104944, 2007, A1. Location in patent: Page/Page column 43
[2] Patent: WO2006/46023, 2006, A1. Location in patent: Page/Page column 123
[3] Patent: WO2008/75109, 2008, A1. Location in patent: Page/Page column 112
[4] Patent: WO2006/46024, 2006, A1. Location in patent: Page/Page column 118
[5] Patent: WO2007/125321, 2007, A2. Location in patent: Page/Page column 116

6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol Suppliers

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View Lastest Price from 6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol manufacturers

Career Henan Chemical Co

Product: 6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol 7400-06-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

7400-06-8, 6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-olRelated Search:

Tofacitinib impurity T Methyl (4-Methylpiperidin-3-yl)carbaMate 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE BENZYL ETHYL ETHER 4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Tofacitinib Impurity 85 N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 4-Amino-2,6-dichloropyrimidine Malonyl chloride Benzyl chloride 6-AMINO-5(2,2-DIETHOXYETHYL)-4-HYDROXY-2-MERCAPTOPYRIMIDINE 1-Benzyl-4-methyl-piperidin-3-one hydrochloride CYANOACETIC ACID-OSU N-Hydroxysuccinimide Tofacitinib Impurity 29 N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine Tofacitinib Impurity 19

6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol

6-aMino-5-(2,2-diethoxyethyl)pyriMidin-4(3H)-one

6-AMino-5-(2,2-diethoxyethyl)-4(3H)-pyriMidinone

NSC 59250

4(3H)-PyriMidinone, 6-aMino-5-(2,2-diethoxyethyl)-

6-aMino-5-(2,2-diethoxyethyl)-1,4-dihydropyriMidin-4- one

6-amino-5-(2,2-diethoxyethyl)-1H-pyrimidin-4-one

6-Amino-5-(2,2-diethoxyethyl)

Tofacitinib Impurity 203

4-amino-6-hydroxy-5-(2,2-diethoxyethyl)pyrimidine

7400-06-8

Amines

Aromatics

Bases & Related Reagents

Heterocycles

Intermediates

Nucleotides