ChemicalBook > CAS DataBase List > 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

Product Name
5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
CAS No.
1048371-03-4
Chemical Name
5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
Synonyms
CS-874;UPF 1069;UPF 1069 10MG;UPF1069/UPF-1069;UPF 1069, 10 mM in DMSO;UPF 1069;UPF-1069; UPF1069;5-Phenacyloxy-2H-isoquinolin-1-one;5-(2-Oxo-2-phenylethoxy)isoquinolin-1(2H)-one;5-(2-Oxo-2-phenylethoxy)-1(2H)-isoquinolinone;1(2H)-Isoquinolinone, 5-(2-oxo-2-phenylethoxy)-
CBNumber
CB42518774
Molecular Formula
C17H13NO3
Formula Weight
279.29
MOL File
1048371-03-4.mol
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5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Property

storage temp. 
Store at RT
solubility 
Soluble in DMSO (up to 40 mg/ml).
form 
solid
color 
Off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Safety

Hazard Codes 
Xn
Risk Statements 
22
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17760
Product name
UPF-1069
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17760
Product name
UPF-1069
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
17760
Product name
UPF-1069
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
17760
Product name
UPF-1069
Purity
≥98%
Packaging
50mg
Price
$381
Updated
2024/03/01
TRC
Product number
U800095
Product name
UPF1069
Packaging
50mg
Price
$455
Updated
2021/12/16
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5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Chemical Properties,Usage,Production

Description

UPF-1069 (1048371-03-4) is a selective PARP-2 inhibitor (IC50=0.3 μM and ~ 27-fold selective against PARP-1).1,2?Increases apoptosis in hippocampal slices but protects cortical cells in models of post-ischemic brain damage.3?Blocks the interaction between PARP-2 and FOXA1, attenuating androgen receptor-mediated gene expression and inhibiting androgen receptor-positive prostate cancer growth.4

Uses

UPF 1069, is a Selective PARP-2 inhibitor.

IC 50

PARP-2: 0.3 μM (IC50); PARP-1: 8 μM (IC50)

References

[1] ROBERTO PELLICCIARI PROF. On the Way to Selective PARP-2 Inhibitors. Design, Synthesis, and Preliminary Evaluation of a Series of Isoquinolinone Derivatives[J]. ChemMedChem, 2008, 3 6: 914-923. DOI:10.1002/cmdc.200800010
[2] ANN-GERD THORSELL. Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors[J]. Journal of Medicinal Chemistry, 2016, 60 4: 1262-1271. DOI:10.1021/acs.jmedchem.6b00990
[3] F MORONI. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage[J]. British Journal of Pharmacology, 2009, 157 5: 854-862. DOI:10.1111/j.1476-5381.2009.00232.x
[4] BIN GUI. Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2019: 14573-14582. DOI:10.1073/pnas.1908547116

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Suppliers

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View Lastest Price from 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one manufacturers

Career Henan Chemical Co
Product
5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one 1048371-03-4
Price
US $1.00/g
Min. Order
100g
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-20

1048371-03-4, 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-oneRelated Search:

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  • 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
  • UPF 1069
  • 5-(2-Oxo-2-phenylethoxy)-1(2H)-isoquinolinone
  • 1(2H)-Isoquinolinone, 5-(2-oxo-2-phenylethoxy)-
  • UPF 1069;UPF-1069; UPF1069
  • UPF 1069 10MG
  • UPF1069/UPF-1069
  • CS-874
  • 6H-Oxazolo[4,5-g][3]benzazepine, 7,8,9,10-tetrahydro-8-
  • 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one USP/EP/BP
  • 5-(2-Oxo-2-phenylethoxy)isoquinolin-1(2H)-one
  • UPF 1069, 10 mM in DMSO
  • 5-Phenacyloxy-2H-isoquinolin-1-one
  • 1048371-03-4
  • Inhibitors
  • Inhibitor