FMoc-NH-5(ethylene glycol)-acetic acid

ChemicalBook > CAS DataBase List > FMoc-NH-5(ethylene glycol)-acetic acid

FMoc-NH-5(ethylene glycol)-acetic acid

Product Name: FMoc-NH-5(ethylene glycol)-acetic acid
CAS No.: 635287-26-2
Chemical Name: FMoc-NH-5(ethylene glycol)-acetic acid
Synonyms: FmocNH-P5-CH2CO2H;FMoc-NH-PEG5-CH2COOH;Fmoc-PEG5-acetic acid;Fmoc-NH-5(ethylene glycol)-actic acid;FMoc-NH-5(ethylene glycol)-acetic acid;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid;17-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12,15-pentaoxaheptadecanoic acid;5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester;Fmoc-NH-PEG5-CH2COOH(1-(9H-Fluoren-9-ylmethyl) 5,8,11,14,17-pentaoxa-2-azanonadecanedioate);FmocNH-PEG5-CH2COOH/5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester
CBNumber: CB42546850
Molecular Formula: C27H35NO9
Formula Weight: 517.57
MOL File: 635287-26-2.mol

Less

FMoc-NH-5(ethylene glycol)-acetic acid Property

Boiling point:: 704.3±60.0 °C(Predicted)
Density: 1.224±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 3.39±0.10(Predicted)

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

AK Scientific

Product number: 0364AP
Product name: Fmoc-NH-PEG5-CH2COOH
Packaging: 250mg
Price: $303
Updated: 2021/12/16

ChemPep

Product number: 280104
Product name: Fmoc-NH-PEG5-CH2COOH
Packaging: 1g
Price: $306
Updated: 2021/12/16

Activate Scientific

Product number: AS103968
Product name: FmocNH-PEG5-CH2COOH
Purity: 95+%
Packaging: 1g
Price: $413
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1412
Product name: Fmoc-NH-PEG5-CH2COOH
Packaging: 500mg
Price: $607
Updated: 2021/12/16

chempep

Product number: 280104
Product name: Fmoc-NH-PEG5-CH2COOH
Purity: >=95%
Packaging: 5g
Price: $820
Updated: 2021/12/16

Less

FMoc-NH-5(ethylene glycol)-acetic acid Chemical Properties,Usage,Production

Description

Fmoc-NH-PEG5-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Biological Activity

Fmoc-NH-PEG5-CH2COOH is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

Cleavable

Alkyl/ether

PEGs

FMoc-NH-5(ethylene glycol)-acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Less

FMoc-NH-5(ethylene glycol)-acetic acid Suppliers

China 67 India 1 United Kingdom 1 United States 10 Global 79

Chengdu Pukang Biotechnology Co., Ltd

Tel: 028-82550498 19102685862
Fax: 086-28-82550468
Email: sales@pu-kang.com
Country: China
ProdList: 485
Advantage: 58

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9900
Advantage: 58

Nanjing Anyan Pharmaceutical Technology Co. , Ltd.

Tel: 025-5836128; 18136859766
Fax: QQ3209878052
Email: amy.xiang@ally-chem.com
Country: China
ProdList: 357
Advantage: 60

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9986
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41438
Advantage: 60

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883 15367835770
Fax: 0731-82251112
Email: viola@huatengsci.com
Country: China
ProdList: 5877
Advantage: 58

Shanghai Boka-chem Tech. Inc.

Tel: 400-026-1533/(021) 6478-0600
Fax: +86 (21) 6459-2060
Email: sales@bokachem.com
Country: China
ProdList: 876
Advantage: 58

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9767
Advantage: 58

AN PharmaTech Co Ltd

Tel: 86(21)68097365
Fax: 86(21)33321566
Email: sales@anpharma.net
Country: China
ProdList: 4901
Advantage: 55

Tongling HengYou Biotechnology Co., Ltd.

Tel: 021-50426030 13856289449
Fax: 021-50426030
Email: 2630597085@qq.com
Country: China
ProdList: 1889
Advantage: 55

Borenpharm Co., Ltd

Tel: 027-65563561
Fax: 86-27-59218822
Email: sales@borenpharm.com
Country: China
ProdList: 1246
Advantage: 55

Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14623
Advantage: 60

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 9859
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28821
Advantage: 58

Hangzhou HanLai Biochemical Technology Co., Ltd.

Tel: 0571-86101219 13675881727
Fax: -
Email: sales@leobiochem.com
Country: China
ProdList: 433
Advantage: 58

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15396
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 18016230971
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 24971
Advantage: 58

Henan Alfachem Co.,Ltd.

Tel: 0371-0371-55051623 18137891487
Fax: QQ：2853979817
Email: 2853979817@qq.com
Country: China
ProdList: 9994
Advantage: 58

Alpha Biopharmaceuticals Co., Ltd

Tel: 0411-39042497
Fax: 0411-39042693
Email: sales@alphabiopharm.com
Country: China
ProdList: 1951
Advantage: 58

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
Fax: 18327183813
Email: amber@biochempartner.com
Country: China
ProdList: 3063
Advantage: 58

Shanghai Moss Medicine Technology Co., Ltd.

Tel: +86-188369842 +86-15618151133
Fax: QQ188369842
Email: 188369842@qq.com
Country: China
ProdList: 1947
Advantage: 58

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19994
Advantage: 58

Nextpeptide Inc

Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Country: China
ProdList: 19915
Advantage: 58

Hangzhou Huarong Pharm Co., Ltd.

Tel: 571-86758373 +8613588754946
Fax: 0086-571-81131109
Email: sales@huarongpharm.com
Country: CHINA
ProdList: 3149
Advantage: 58

Wuhan Borenpharm Co., Ltd

Tel: 027-65563561 18717150066
Fax: 027-59218822
Email: 3207347307@qq.com
Country: CHINA
ProdList: 1238
Advantage: 58

Wuhan Anruike Pharmaceutical Technology Co., Ltd.

Tel: 18572841024
Fax: QQ：28128719
Email: 28128719@qq.com
Country: China
ProdList: 1985
Advantage: 58

Shanghai Galedo Biotechnology Co., Ltd.

Tel: 021 60642329 19946252459
Fax: QQ：1072302796
Email: sales@galedo-bio.com
Country: China
ProdList: 2018
Advantage: 58

Chengdu Pukang Biotechnology Co., Ltd

Tel: 028-82550498
Email: export@pu-kang.com
Country: CHINA
ProdList: 210
Advantage: 58

Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

Tel: 029-86217788 13892832556
Email: 2440688701@qq.com
Country: China
ProdList: 1992
Advantage: 58

Shanghai Jiange Chemical Co., Ltd.

Tel: 15921040873
Email: 1434142450@qq.com
Country: CHINA
ProdList: 7651
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-61398051 +8613650506873
Email: sales@chemdad.com
Country: China
ProdList: 39916
Advantage: 58

Shaanxi borno biotechnology co., LTD

Tel: +86-13759708231
Email: asherw9@hotmail.com
Country: China
ProdList: 2351
Advantage: 58

Zhengzhou anmousse chemical products co. LTD

Tel: 0371-55289822 18737195735
Fax: QQ:483339295
Email: 483339295@qq.com
Country: China
ProdList: 7088
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49323
Advantage: 58

Nanjing chengqimei Biotechnology Co., Ltd

Tel: 19850819832
Email: 2173594524@qq.com
Country: China
ProdList: 2638
Advantage: 58

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

Tel: +86-021-61551413 +8618813727289
Email: contact@trustwe.com
Country: China
ProdList: 5738
Advantage: 58

Changzhou Kechem Bio-Scientific Co., LTD.

Tel: 0519-68985668 13685222090
Fax: qq735434464
Email: sales@kechem.cn
Country: China
ProdList: 26033
Advantage: 58

Guangzhou Hongyuan Chemical Co.,Ltd

Tel: 15817493340
Email: 981810490@qq.com
Country: China
ProdList: 405
Advantage: 58

Jiaxing Hengrui Biotechnology Co. LTD

Tel: 0573-82672231 13757365595
Fax: QQ：715584339
Email: regen_chemical1@163.com
Country: China
ProdList: 3861
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44489
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 31163
Advantage: 58

Xi'an Qiyue Biotechnology Co., Ltd.

Tel: 400-400-6966-012-012 17778955912
Email: 2957605606@qq.com
Country: China
ProdList: 2535
Advantage: 58

Shanghai Huici Pharmaceutical Technology Co., LTD

Tel: 19372841038 19372841038
Email: lixing@pharmahuici.com
Country: China
ProdList: 216
Advantage: 58

Zhejiang Rui 'ao Biological Technology Co.,LTD.

Tel: 0573-82087565 18966369783
Email: sales@ruiaobio.com
Country: China
ProdList: 628
Advantage: 58

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-80514535 19917294565
Email: et@chemextension.com
Country: China
ProdList: 5061
Advantage: 58

Guangzhou Weihua Biotechnology Co., Ltd

Tel: 020-020-37239396 18922492046
Email: weihuasw@foxmail.com
Country: China
ProdList: 2064
Advantage: 58

Shaoguan Qicheng Biotechnology Co., Ltd

Tel: 18122215013
Email: 780229652@qq.com
Country: China
ProdList: 939
Advantage: 58

Shaanxi Xihua Chemical Industry Co., Ltd

Tel: 17691182729 15529505138
Email: 1021@dideu.com
Country: China
ProdList: 9998
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50471
Advantage: 58

635287-26-2, FMoc-NH-5(ethylene glycol)-acetic acidRelated Search:

alpha, oMega-Dipropionic acid triethylene glycol O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL HEXAETHYLENE GLYCOL MONOMETHYL ETHER 2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHANOL 2-(2-Methoxyethoxy)ethanamine 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosane-28-thiol HEPTAETHYLENE GLYCOL MONOMETHYL ETHER FMOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID Fmoc-N-amido-PEG11-acid FMoc-NH-8(ethylene glycol)-acetic acid Fmoc-N-amido-PEG17-acid Fmoc-NH-PEG2-CH2CO2H Fmoc-NH-PEG3-CH2COOH Fmoc-N-amido-PEG15-acid 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid,1-(9-fluren-9-ylmethyl)ester FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID Fmoc-N-amido-PEG14-acid FMoc-NH-PEG9-CH2CH2COOH

Fmoc-PEG5-acetic acid

1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid

FMoc-NH-5(ethylene glycol)-acetic acid

FMoc-NH-PEG5-CH2COOH

5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester

Fmoc-NH-5(ethylene glycol)-actic acid

17-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12,15-pentaoxaheptadecanoic acid

{2-[2-(2-{2-[2-(9H-fluoren-9-yl-methoxycarbonylamino)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}acetic acid

FmocNH-P5-CH2CO2H

FmocNH-PEG5-CH2COOH/5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester

Fmoc-NH-PEG5-CH2COOH(1-(9H-Fluoren-9-ylmethyl) 5,8,11,14,17-pentaoxa-2-azanonadecanedioate)

2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid

635287-26-2

peg