ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE

Product Name: ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE
CAS No.: 126401-22-7
Chemical Name: ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE
Synonyms: ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE;1-Benzyl 2-ethyl piperidine-1,2-dicarboxylate;1,2-Piperidinedicarboxylic acid, 2-ethyl 1-(phenylMethyl) ester
CBNumber: CB42583028
Molecular Formula: C16H21NO4
Formula Weight: 291.34
MOL File: 126401-22-7.mol

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ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE Property

Boiling point:: 403.7±45.0 °C(Predicted)
Density: 1.165±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -3.21±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: X0397
Product name: Ethyl-N-Cbz-piperidine-2-carboxylate
Packaging: 1g
Price: $27
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0237493
Product name: ETHYL-N- CBZ -PIPERIDINE-2-CARBOXYLATE
Purity: 95.00%
Packaging: 5G
Price: $1322.48
Updated: 2021/12/16

Chemenu

Product number: CM179849
Product name: 1-Benzyl2-ethylpiperidine-1,2-dicarboxylate
Purity: 97%
Packaging: 25g
Price: $148
Updated: 2021/12/16

Chemenu

Product number: CM179849
Product name: 1-Benzyl2-ethylpiperidine-1,2-dicarboxylate
Purity: 97%
Packaging: 100g
Price: $421
Updated: 2021/12/16

Alichem

Product number: 126401227
Product name: 1-Benzyl2-ethylpiperidine-1,2-dicarboxylate
Packaging: 100g
Price: $445.5
Updated: 2021/12/16

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ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

501-53-1

15862-72-3

126401-22-7

A dichloromethane solution of benzyl chloroformate (17 g, 100 mmol) was added slowly and dropwise to a stirred dichloromethane (100 ml) solution of ethyl 2-piperidinecarboxylate (15 g, 95 mmol), triethylamine (27 ml, 191 mmol), and 4-dimethylaminopyridine (0.58 g, 4.8 mmol) at 0 °C. The reaction mixture was slowly warmed up to room temperature and stirred continuously at room temperature for 16 hours (overnight) followed by standing for 2 days. After completion of the reaction, the crude product was extracted with dichloromethane and washed sequentially with 1N hydrochloric acid, saturated aqueous sodium bicarbonate solution and brine. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuum. The residue was purified by column chromatography on silica gel 60 (300 g) with cyclohexane/ethyl acetate as eluent to afford the light yellow oily target product ethyl N-Cbz-piperidine-2-carboxylate. Yield: 17.9 g (62% yield). The product was analyzed by HPLC (Method 6): retention time Rt = 4.91 min, maximum absorption wavelength λmax = 202 nm; mass spectrometry (ESI positive ion mode): m/z = 309 ([M+NH4]+).

References

[1] Patent: WO2005/82864, 2005, A1. Location in patent: Page/Page column 41-42
[2] Journal of the American Chemical Society, 2011, vol. 133, # 49, p. 19698 - 19701
[3] Angewandte Chemie - International Edition, 2012, vol. 51, # 42, p. 10660 - 10663
[4] Angew. Chem., 2012, vol. 124, # 42, p. 10815 - 10819,5

ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE Suppliers

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View Lastest Price from ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE 126401-22-7
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

126401-22-7, ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATERelated Search:

Ethyl N- Cbz -piperidine-4-carboxylate Diethylzinc 2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Methyl N-methyl piperidine-4-carboxylate N-Boc-Piperidine-4-carboxylic acid methyl ester Benzyl 2-methylpiperidine-1,2-dicarboxylate Ethyl N-Boc-piperidine-4-carboxylate ETHYL 1-BENZYLPIPERIDINE-3-CARBOXYLATE Ethyl 1-benzylpiperidine-4-carboxylate 4-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

ETHYL 1-CBZ-PIPERIDINE-2-CARBOXYLATE

1,2-Piperidinedicarboxylic acid, 2-ethyl 1-(phenylMethyl) ester

1-Benzyl 2-ethyl piperidine-1,2-dicarboxylate

126401-22-7