γ-Secretase Inhibitor XXI

Product Name: γ-Secretase Inhibitor XXI
CAS No.: 209986-17-4
Chemical Name: γ-Secretase Inhibitor XXI
Synonyms: DuPont E;γ-Secretase-IN-1;Compound E, gamma;-secretase inhibitor;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor XXI;g-Secretase Inhibitor XXI;γ-Secretase Inhibitor XXI;Compound E (γ-Secretase-IN-1)
CBNumber: CB42602844
Molecular Formula: C27H24F2N4O3
Formula Weight: 490.5
MOL File: 209986-17-4.mol

More

Less

γ-Secretase Inhibitor XXI Property

Boiling point:: 778.6±60.0 °C(Predicted)
Density: 1.31
storage temp.: = -70C
solubility: Soluble in DMSO
form: Liquid
pka: 12.54±0.40(Predicted)
color: White to off-white
Sensitive: Light Sensitive

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 565790
Product name: γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem
Purity: Thisg-secretaseinhibitor,CAS209986-17-4,isacell-permeable,potent,select
Packaging: 500μg
Price: $345
Updated: 2024/03/01

Sigma-Aldrich

Product number: 565790
Product name: γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem
Packaging: 1mg
Price: $445
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.30509
Product name: StemSelect Compound E - CAS 209986-17-4 - Calbiochem
Packaging: 250μg
Price: $209
Updated: 2024/03/01

Alfa Aesar

Product number: J65131
Product name: Compound E
Packaging: 0.5mg
Price: $307
Updated: 2023/06/20

Cayman Chemical

Product number: 15579
Product name: Compound E
Purity: ≥98%
Packaging: 500μg
Price: $189
Updated: 2024/03/01

More

Less

γ-Secretase Inhibitor XXI Chemical Properties,Usage,Production

Uses

A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of -secretase and Notch processing

Definition

ChEBI: Compound E is an L-alanine derivative that is the amide obtained by formal condensation of the carboxy group of N-[(3,5-difluorophenyl)acetyl]-L-alanine with the amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one. An inhibitor of memapsin 2 (gamma-secretase). It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor. It is a 1,4-benzodiazepinone, a L-alanine derivative and a difluorobenzene.

storage

+4°C

γ-Secretase Inhibitor XXI Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

γ-Secretase Inhibitor XXI Suppliers

China 50 United Kingdom 2 United States 12 Global 64

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Alabiotech Inc.

Tel: 001-619-354-5251
Fax: 001-855-855-6087
Email: sales@alabiotech-e.com
Country: United States
ProdList: 972
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52925
Advantage: 58

Syncom BV

Tel: --
Fax: --
Email: info@syncom.nl
Country: United States
ProdList: 75
Advantage: 0

Santa Cruz Biotechnology, Inc.

Tel: --
Fax: --
Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

Creative Enzymes

Tel: --
Fax: --
Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Axon Medchem LLC

Tel: --
Fax: --
Email: info@axonmedchem.com
Country: United States
ProdList: 763
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

209986-17-4, γ-Secretase Inhibitor XXIRelated Search:

BETA-SECRETASE INHIBITOR IV DAPM GAMMA-SECRETASE INHIBITOR DIBENZAZEPINE Sulfanilamide Deionized water N,N'-Ethylenebis(stearamide) 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol DAPT

γ-Secretase Inhibitor XXI

N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide

CoMpound E (secretase inhibitor)

DuPont E

g-Secretase Inhibitor XXI

γ-Secretase Inhibitor BZ

(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S,Z)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide

(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide

StemSelect Compound E - CAS 209986-17-4 - Calbiochem

BZ, γ-Secretase Inhibitor - Compound E

Compound E (γ-Secretase Inhibitor XXI)

Benzeneacetamide, N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-

γ-Secretase Inhibitor BZ

γ-Secretase Inhibitor XXI

Compound E, gamma

-secretase inhibitor

γ-Secretase-IN-1

Compound E (γ-Secretase-IN-1)

(2S)-2-[2-(3,5-difluorophenyl)acetamido]-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide

209986-17-4

C27H24F2N4O3