1-Methyl-4-piperidinemethanol

Application

Product Name: 1-Methyl-4-piperidinemethanol
CAS No.: 20691-89-8
Chemical Name: 1-Methyl-4-piperidinemethanol
Synonyms: BUTTPARK 145\16-21;CHEMBRDG-BB 4002191;1-Methyl-4-piperidinemeth...;1-Methyl-4-piperidinemethano;1-Methylpiperidine-4-methanol;1-METHYL-4-PIPERIDINEMETHANOL;N-METHYL-4-PIPERIDINEMETHANOL;N-Methyl-piperidin-4-Methanol;4-Methoxy-1-Methyl-piperidine;N-Methyl-4-piperidinecarbinol
CBNumber: CB4261157
Molecular Formula: C7H15NO
Formula Weight: 129.2
MOL File: 20691-89-8.mol

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1-Methyl-4-piperidinemethanol Property

Boiling point:: 108°C/10mmHg(lit.)
Density: 0.981 g/mL at 25 °C
refractive index: 1.476
Flash point:: 110℃
storage temp.: Inert atmosphere,Room Temperature
pka: 14.94±0.10(Predicted)
form: Liquid
color: Colorless to yellow
InChI: InChI=1S/C7H15NO/c1-8-4-2-7(6-9)3-5-8/h7,9H,2-6H2,1H3
InChIKey: KJZLJGZZDNGGCA-UHFFFAOYSA-N
SMILES: N1(C)CCC(CO)CC1
CAS DataBase Reference: 20691-89-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-36
Safety Statements: 26-36/37/39
RIDADR: 2735
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 737399
Product name: 4-(Hydroxymethyl)-1-methylpiperidine
Purity: 97%
Packaging: 1g
Price: $48.7
Updated: 2023/06/20

TCI Chemical

Product number: M2242
Product name: 1-Methyl-4-piperidinemethanol
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $80
Updated: 2025/07/31

TCI Chemical

Product number: M2242
Product name: 1-Methyl-4-piperidinemethanol
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $257
Updated: 2025/07/31

TRC

Product number: M331568
Product name: 1-Methyl-4-piperidinemethanol
Packaging: 250mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-KU
Product name: 1-Methyl-4-piperidinemethanol
Packaging: 5G
Price: $45
Updated: 2021/12/16

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1-Methyl-4-piperidinemethanol Chemical Properties,Usage,Production

Application

1-Methyl-4-piperidinemethanol is a common organic synthon, frequently used in the synthesis of drug molecules and bioactive molecules. The hydroxyl group in its structure can be converted into a chlorine atom by thionyl chloride. During the chlorination reaction, hydrogen chloride is produced, which combines with a tertiary amine, so the product is often an amine salt.

Chemical Properties

Colorless liquid

Synthesis

24252-37-7

20691-89-8

The general procedure for the synthesis of 1-methyl-4-piperidinemethanol from ethyl N-methyl-4-piperidinecarboxylate is as follows: Synthesis of Example 23 (1-methylpiperidin-4-yl)methanol (22): a solution of ethyl N-methyl-4-piperidinecarboxylate (21, 10.1 g, 59.0 mmol) in ethyl ether (Et2O, 40 mL) was slowly added dropwise to an ethyl ether suspension of lithium aluminum hydride (LiAlH4, 2.46 g, 64.9 mmol). The reaction system was cooled at 0 °C, followed by the addition of ether (200 mL). The reaction mixture was gradually warmed to room temperature and stirred continuously at this temperature for 4 hours. Upon completion of the reaction, the reaction was quenched by the slow addition of water (10 mL) and stirring was continued for 30 minutes. The resulting white precipitate was separated by filtration and washed well with ether (250 mL). After concentration under reduced pressure to remove the solvent, the oily product obtained was purified by distillation under reduced pressure (boiling point 108 °C, 14 mbar) to give the target compound 22 (6.40 g, 84% yield) as a colorless oil. -Thin layer chromatography (TLC) analysis: Rf = 0.53 (Expanding agent: dichloromethane/methanol = 5:1 with 5% triethylamine, phosphomolybdic acid color development: dark blue spots). -Nuclear magnetic resonance hydrogen spectrum (1H NMR, 300MHz, CDCl3): δ= 1.28 (dq, J = 12.2, 3.7Hz, 2H, 3-Hax, 5-Hax), 1.38-1.55 (m, 1H, 4-H), 1.68-1.79 (m, 2H, 3-Heq, 5-Heq), 1.93 (dt, J = 11.8, 2.3Hz, 2H, 2H, 4-H). 2.3 Hz, 2H, 2-Hax, 6-Hax), 2.26 (s, 3H, NMe), 2.82-2.92 (m, 2H, 2-Heq, 6-Heq), 3.12 (sbr, 1H, OH), 3.46 (d, J = 6.4 Hz, 2H, CH2OH) ppm. -Nuclear magnetic resonance carbon spectrum (13C NMR, 75.5 MHz, CDCl3): δ= 28.8 (C-3, C-5), 37.9 (C-4), 46.3 (NMe), 55.5 (C-2, C-6), 67.4 (CH2OH) ppm. -Mass spectrum (MS, 70eV, EI): m/z (%) = 129 (55) [M]+, 128 (100) [M-H]+, 112 (10) [M-OH]+, 98 (21) [M-CH2OH]+. -Molecular formula: C7H15NO (molecular weight: 129.20).

References

[1] European Journal of Organic Chemistry, 2006, # 10, p. 2314 - 2321
[2] Patent: US2009/318668, 2009, A1. Location in patent: Page/Page column 52
[3] Patent: WO2007/89149, 2007, A2. Location in patent: Page/Page column 96
[4] Journal of the American Chemical Society, 1952, vol. 74, p. 3831
[5] Patent: WO2005/95387, 2005, A1. Location in patent: Page/Page column 68

1-Methyl-4-piperidinemethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Methyl-4-piperidinemethanol Suppliers

Americas 1 China 205 Europe 1 France 1 Germany 4 India 4 Japan 2 Russia 1 Switzerland 2 Ukraine 1 United Kingdom 12 United States 34 Global 268

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View Lastest Price from 1-Methyl-4-piperidinemethanol manufacturers

Anhui Zhongda Biotechnology Co., Ltd

Product: 1-Methyl-4-piperidinemethanol 20691-89-8
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100tons
Release date: 2023-10-23

Hebei Mingeng Biotechnology Co., Ltd

Product: 1-Methyl-4-piperidinemethanol 20691-89-8
Price: US $180.00/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 500kg/month
Release date: 2022-05-06

Jinan Ande Pharmaceutical Co.,Ltd.

Product: 1-Methyl-4-piperidinemethanol 20691-89-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100
Release date: 2021-12-20

20691-89-8, 1-Methyl-4-piperidinemethanolRelated Search:

Kresoxim-methyl Methyl acrylate Methyl acetate Bensulfuron methyl Methylparaben METSULFURON METHYL 1-METHYL-3-PIPERIDINEMETHANOL 4-Chloro-N-methylpiperidine Methyl N-methyl piperidine-4-carboxylate Ethyl 1-methyl-4-piperidinecarboxylate Ethyl 1-methylnipecotate 1-Methyl-4-piperidone Thiophanate-methyl Methyl Parathion-methyl Methyl bromide MEPERIDINE HYDROCHLORIDE 1-Acetyl-4-piperidinecarboxylic acid

CHEMBRDG-BB 4002191

BUTTPARK 145\16-21

1-Methyl-4-piperidinemethano

1-Methylpiperidine-4-methanol

(1-METHYL-PIPERIDIN-4-YL)-METHANOL

1-METHYL-4-PIPERIDINEMETHANOL

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N-Methyl-piperidin-4-Methanol

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4-Methoxy-1-Methyl-piperidine

1-Methyl-4-piperidinemethanol&gt

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N-methyl-4-piperidinyl alcohol

N-Methyl-4-piperidinecarbinol

20691-89-8

Heterocyclic Compounds

pharmacetical

Piperidine

Alcohols and Derivatives