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CC0651

Product Name
CC0651
CAS No.
1319207-44-7
Chemical Name
CC0651
Synonyms
CC0651;CC0651,CC-0651;(2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid;4,5-Dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-L-arabinonic acid;L-Arabinonic acid, 4,5-dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-
CBNumber
CB42627678
Molecular Formula
C20H21Cl2NO6
Formula Weight
442.29
MOL File
1319207-44-7.mol
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CC0651 Property

Boiling point:
755.7±60.0 °C(Predicted)
Density 
1.410±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: ≥ 56 mg/mL (126.61 mM)
pka
3.37±0.34(Predicted)
form 
Powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.09704
Product name
Cdc34 Inhibitor, CC0651 - CAS 1319207-44-7 - Calbiochem
Purity
A cell-permeable, selective allosteric inhibitor of E2 ubiquitin-conjugating enzyme Cdc34 (IC?? = 2.5 μM in a Sic1-SCFCdc4 assay).
Packaging
10MG
Price
$240
Updated
2023/06/20
TRC
Product number
C263475
Product name
CC0651
Packaging
2.5mg
Price
$435
Updated
2021/12/16
TRC
Product number
C263475
Product name
CC0651
Packaging
1mg
Price
$215
Updated
2021/12/16
ChemScene
Product number
CS-2109
Product name
CC0651
Purity
99.52%
Packaging
5mg
Price
$1176
Updated
2021/12/16
ChemScene
Product number
CS-2109
Product name
CC0651
Purity
99.52%
Packaging
10mg
Price
$1800
Updated
2021/12/16
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CC0651 Chemical Properties,Usage,Production

General Description

A cell-permeable biphenylylpentanoic acid compound that acts as a selective allosteric inhibitor of E2 ubiquitin-conjugating enzyme Cdc34 (IC50 = 2.5 μM in a Sic1-SCFCdc4 assay) without affecting the activities of E1 or E3 ligases. Reported to act by trapping a weak interaction between ubiquitin and the E2 donor ubiquitin-binding site and may serve as a molecular bridge between Cdc34A and ubiquitin. Binds to Cdc34ACAT alone with an EC50 value of 267 μM, but in the presence of ubiquitin, this affinity is significantly increased (EC50 = 19 μM). Does not disrupt the interaction of Cdc34A with the RING domain of Rbx1 and is suggested to even moderately stabilize this interaction. Shown to inhibit p27Kip1 ubiquitination (IC50 = 1.72 μM) and reduce PC-3 cancer cells proliferation (~30 μM).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes

CC0651 Preparation Products And Raw materials

Raw materials

Preparation Products

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CC0651 Suppliers

China 28 United Kingdom 1 United States 9 Global 38
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

1319207-44-7, CC0651Related Search:

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  • (2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid
  • L-Arabinonic acid, 4,5-dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-
  • CC0651
  • 4,5-Dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-L-arabinonic acid
  • CC0651,CC-0651
  • 1319207-44-7
  • C20H21Cl2NO6