ChemicalBook > CAS DataBase List > Sarecycline Hydrochloride
Sarecycline Hydrochloride
- Product Name
- Sarecycline Hydrochloride
- CAS No.
- 1035979-44-2
- Chemical Name
- Sarecycline Hydrochloride
- Synonyms
- Sarecycline;Sarecycline HCl;P005672;P005672 HCl;P005672 (hydrochloride);CS-267;PO05672;PO05672 HCl;P0-05672;P0 05672;Sarecycline(P005672)
- CBNumber
- CB42648136
- Molecular Formula
- C24H30ClN3O8
- Formula Weight
- 523.97
- MOL File
- 1035979-44-2.mol
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Sarecycline Hydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 0.25 mg/ml,DMSO: 0.25 mg/ml
- form
- Solid
- color
- Light yellow to yellow
- InChIKey
- APPRLAGZQKOUFL-ZKOKXHCXNA-N
- SMILES
- O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])C[C@]1([H])CC3=C(C=CC(O)=C3C(=O)C1=C2O)CN(C)OC)=O.Cl |&1:1,9,13,16,r|
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 24685
- Product name
- P005672 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $43
- Updated
- 2023/01/06
Cayman Chemical
- Product number
- 24685
- Product name
- P005672 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $191
- Updated
- 2023/01/06
Cayman Chemical
- Product number
- 24685
- Product name
- P005672 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $359
- Updated
- 2023/01/06
Cayman Chemical
- Product number
- 24685
- Product name
- P005672 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $739
- Updated
- 2023/01/06
TRC
- Product number
- S140525
- Product name
- SarecyclineHydrochloride
- Packaging
- 50mg
- Price
- $1575
- Updated
- 2021/12/16
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Sarecycline Hydrochloride Chemical Properties,Usage,Production
Uses
Sarecycline Hydrochloride is a substituted tetracycline compound used for treatment of bacterial infections and neoplasms.
Biological Activity
Sarecycline Hydrochloride iinhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome. Specifically, it binds to the A site of the ribosome and blocks the attachment of aminoacyl-tRNA molecules to the ribosome, which is necessary for the addition of new amino acids to the growing polypeptide chain. This ultimately leads to the inhibition of bacterial protein synthesis and reduction in bacteria th at are associated with acne.
in vivo
Sarecycline hydrochloride (0.33-9? mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model[1].
Sarecycline can inhibit S. aureus (PD50=0.25 mg/kg), but has no significant effect on E. coli even at the highest dose (>40 mg/kg) in CD-1 mice model of systemic (intraperitoneal) infection[6].
Sarecycline (1-150mg/kg; Intraperitoneal injection; Single dose) shows anti-inflammatory activity in Sprague Dawley rats model[6].
| Animal Model: | Female SD-1 mice (A murine neutropenic thigh wound infection model)[1] |
| Dosage: | 0.33, 1, 3, or 9?mg/kg |
| Administration: | Intravenously |
| Result: | Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32?mg/kg, respectively. |
| Animal Model: | Carrageenan-induced footpad edema male Sprague Dawley rats model[6] |
| Dosage: | 1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw. |
| Result: | Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline. |
IC 50
Tetracycline
Sarecycline Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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Sarecycline Hydrochloride Suppliers
- Tel
- 025-58741518 13327727315
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- China
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- Fax
- +86 (21) 6129-4103
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View Lastest Price from Sarecycline Hydrochloride manufacturers
Jinan Ruitong Biotech Co., Ltd.
- Product
- Sarecycline
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-22
Shaanxi Dideu New Materials Co. Ltd
- Product
- Sarecycline Hydrochloride 1035979-44-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-08
ShenZhen H&D Pharmaceutical Technology Co., LTD
- Product
- Minocycline Impurity 14
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 5g
- Release date
- 2024-05-22
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