AGI6780

Description In vitro

Product Name: AGI6780
CAS No.: 1432660-47-3
Chemical Name: AGI6780
Synonyms: CS-1905;CS-1019;AGI6780;AGI-6780, >=98%;AGI6780 USP/EP/BP;AGI-6780, that potently and selectively inhibits the tumor-associated mutant IDH2R140Q;N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoroMethyl)phenyl)ureido)benzenesulfonaMide;N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide;Benzenesulfonamide, N-cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-;N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide AGI-6780
CBNumber: CB42652324
Molecular Formula: C21H18F3N3O3S2
Formula Weight: 481.51
MOL File: 1432660-47-3.mol

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AGI6780 Property

Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥22.25 mg/mL in DMSO; insoluble in H2O; ≥100.8 mg/mL in EtOH
form: solid
pka: 11.78±0.20(Predicted)
color: White to off-white

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Safety

HS Code: 2935909099

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0895
Product name: AGI-6780
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $150
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0895
Product name: AGI-6780
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $598
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.09880
Product name: IDH2 Inhibitor, R140Q Somatic Mutant-Specific, AGI-6780 - CAS 1432660-47-3 - Calbiochem
Packaging: 10mg
Price: $265
Updated: 2024/03/01

Cayman Chemical

Product number: 14639
Product name: AGI-6780
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 14639
Product name: AGI-6780
Purity: ≥98%
Packaging: 5mg
Price: $112
Updated: 2024/03/01

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AGI6780 Chemical Properties,Usage,Production

Description

AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.

In vitro

AGI-6780 potently reduce (R)-2-hydroxyglutarate (2HG) levels in cell lines ectopically overexpressing IDH2/R140Q with EC50 of 20 nM, with excellent selectivity against other dehydrogenases. AGI-6780 reverses the IDH2/R140Q-induced differentiation block in TF-1 cells, and induces blast differentiation in primary human IDH2/R140Q AML patient samples.

Uses

AGI-6780 is a small molecule inhibitor of the tumor associated mutant IDH2 (Isocitrate Dehydrogenase-2) in leukemia cells. This compound is suitable for IDH (isocitrate dehydrogenase) related research.

Biological Activity

agi-6780 is a potent and selective inhibitor of tumor-associated idh2/r140q mutation with ic50 value of 23 nm [1].agi-6780 could significantly reduce intracellular concentration of 2hg in the human glioblastoma tf1/r140q cells, as well as reverse idh2/r140q-mediated differentiation block in tf1 cells in the presence of epo. agi-6780 could restore klf1 and hemoglobin g1/2 expressions in the epo-induced tf1/r140q cells [1].

target

IDH2-R140Q

References

[1] wang f1, travins j, delabarre b, penard-lacronique v, schalm s, hansen e, straley k, kernytsky a, liu w, gliser c, yang h, gross s, artin e, saada v,mylonas e, quivoron c, popovici-muller j, saunders jo, salituro fg, yan s, murray s, wei w, gao y, dang l, dorsch m, agresta s, schenkein dp, biller sa, su sm, de botton s, yen ke. targeted inhibition of mutant idh2 in leukemia cells induces cellular differentiation. science. 2013 may 3;340(6132):622-6.

AGI6780 Preparation Products And Raw materials

Raw materials

Preparation Products

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AGI6780 Suppliers

China 102 India 1 United States 16 Global 119

MedChemexpress LLC

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View Lastest Price from AGI6780 manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: AGI6780 1432660-47-3
Price: US $0.00-0.00/KG
Min. Order: 5g
Purity: 99% HPLC
Supply Ability: 2000tons
Release date: 2019-12-30

Career Henan Chemical Co

Product: AGI6780 1432660-47-3
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

1432660-47-3, AGI6780Related Search:

4SC-202 CEP-32496 N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine PURVALANOL A Testolactone GDC-0077 CC0651 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine IDO-IN-7 UNC 0631 XL 228 N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea AZD-8055 5-Aza-2'-deoxycytidine N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide Trametinib PD 0332991 HCl Olaparib

AGI-6780 N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide

N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide AGI-6780

AGI6780

AGI-6780, >=98%

N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoroMethyl)phenyl)ureido)benzenesulfonaMide

N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide

Benzenesulfonamide, N-cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-

CS-1019

CS-1905

AGI6780 USP/EP/BP

AGI-6780, that potently and selectively inhibits the tumor-associated mutant IDH2R140Q

1432660-47-3

C21H18F3N3O3S2

Inhibitors

API