1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate
- Product Name
- 1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate
- CAS No.
- 362703-34-2
- Chemical Name
- 1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate
- Synonyms
- Methyl 4-cyanopiperidine-4-carboxylate hydrochloride;1-Boc-4-cyano-4-piperidinecarboxylic acid methyl ester;1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate;O1-tert-butyl O4-methyl 4-cyanopiperidine-1,4-dicarboxylate;1,4-Piperidinedicarboxylic acid, 4-cyano-, 1-(1,1-dimethylethyl) 4-methyl ester
- CBNumber
- CB42676414
- Molecular Formula
- C13H20N2O4
- Formula Weight
- 268.31
- MOL File
- 362703-34-2.mol
1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate Property
- Boiling point:
- 377.1±42.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -4.10±0.40(Predicted)
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0038298
- Product name
- 1-tert-Butyl4-methyl4-cyanopiperidine-1,4-dicarboxylate
- Packaging
- 100mg
- Price
- $68
- Updated
- 2021/12/16
- Product number
- 7001DP
- Product name
- 1-Tert-Butyl4-methyl4-cyanopiperidine-1,4-dicarboxylate
- Packaging
- 100mg
- Price
- $111
- Updated
- 2021/12/16
- Product number
- CS-0038298
- Product name
- 1-tert-Butyl4-methyl4-cyanopiperidine-1,4-dicarboxylate
- Packaging
- 250mg
- Price
- $113
- Updated
- 2021/12/16
- Product number
- 7001DP
- Product name
- 1-Tert-Butyl4-methyl4-cyanopiperidine-1,4-dicarboxylate
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- CS-0038298
- Product name
- 1-tert-Butyl4-methyl4-cyanopiperidine-1,4-dicarboxylate
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate Chemical Properties,Usage,Production
Synthesis
362703-33-1
24424-99-5
362703-34-2
The general procedure for the synthesis of methyl N-Boc-4-cyanopiperidine-4-carboxylate from the compound (CAS: 362703-33-1) and di-tert-butyl dicarbonate was as follows: piperidine (640 mg, 2.11 mmol) from reaction (24a), di-tert-butyl dicarbonate (500 mg, 2.3 mmol) and a catalytic amount of palladium hydroxide were dissolved in ethyl acetate ( 10 mL). The hydrogenation reaction was carried out under hydrogen atmosphere at 1 atmosphere. After 3 hours of reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was subsequently concentrated to afford the target product methyl N-Boc-4-cyanopiperidine-4-carboxylate (566 mg, 100% yield). Mass spectral analysis showed (M + H)+ = 269.
References
[1] Patent: US2004/72802, 2004, A1. Location in patent: Page/Page column 46
1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate manufacturers
- Product
- 1-tert-butyl4-Methyl4-cyanopiperidine-1,4-dicarboxylate 362703-34-2
- Price
- US $0.01/KG
- Min. Order
- 500g
- Purity
- 98%; 99%
- Supply Ability
- 500g；1kg； 10kg; 25kg
- Release date
- 2020-01-08