ChemicalBook > CAS DataBase List > 3-Methoxy-2-methylaniline

3-Methoxy-2-methylaniline

Product Name: 3-Methoxy-2-methylaniline
CAS No.: 19500-02-8
Chemical Name: 3-Methoxy-2-methylaniline
Synonyms: 3-Methoxy-2-nitroaniline;3-Metho;3-methoxy-2-methylbenzenamine;2-Nitro-m-anisidine;2-Methyl-M-anisidine;3-METHOXY-O-TOLUIDINE;3-Methoxy-2-methylanili;2-METHYL-3-AMINO ANISOLE;3-AMINO-2-METHYL-ANISOLE;2-AMino-6-Methoxytoluene
CBNumber: CB4278801
Molecular Formula: C8H11NO
Formula Weight: 137.18
MOL File: 19500-02-8.mol

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3-Methoxy-2-methylaniline Property

Melting point:: 27-28°C
Boiling point:: 243.4±20.0 °C(Predicted)
Density: 1.08
refractive index: 1.5730-1.5770
Flash point:: >110℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Oil
pka: 4.03±0.10(Predicted)
color: Brown to Dark Brown
InChI: InChI=1S/C8H11NO/c1-6-7(9)4-3-5-8(6)10-2/h3-5H,9H2,1-2H3
InChIKey: OPXLVWLFDKRYRB-UHFFFAOYSA-N
SMILES: C1(N)=CC=CC(OC)=C1C
CAS DataBase Reference: 19500-02-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
RIDADR: 2810
WGK Germany: 1
HazardClass: 6.1
PackingGroup: III
HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: M1493
Product name: 3-Methoxy-2-methylaniline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $89
Updated: 2025/07/31

TCI Chemical

Product number: M1493
Product name: 3-Methoxy-2-methylaniline
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $330
Updated: 2025/07/31

TRC

Product number: M263300
Product name: 3-Methoxy-2-methylaniline
Packaging: 5G
Price: $95
Updated: 2021/12/16

AK Scientific

Product number: J94864
Product name: 3-Methoxy-2-methylaniline
Packaging: 1g
Price: $10
Updated: 2021/12/16

Matrix Scientific

Product number: 072758
Product name: 3-Methoxy-2-methylaniline
Purity: 95+%
Packaging: 5g
Price: $34
Updated: 2021/12/16

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3-Methoxy-2-methylaniline Chemical Properties,Usage,Production

Chemical Properties

Brown Oil

Uses

3-Methoxy-2-methylaniline is a aniline derivative used in the preparation of indoles and indazoles with potential neurochemical activity, as well as in the preparation of quinoline based antiviral agents.

Synthesis

4837-88-1

19500-02-8

The general procedure for the synthesis of 3-methoxy-2-methylaniline from 2-methyl-3-nitroanisole is as follows (reference Example 42): 1. 9.98 g of a suspension of 5% palladium-carbon (wet) in 100 mL of ethanol was added to a solution of 30.7 g (184 mmol) of 2-methyl-3-nitroanisole in 300 mL of ethanol. 2. The reaction mixture was stirred at room temperature and under hydrogen atmosphere for 3 hours. 3. Upon completion of the reaction, the reaction solution was filtered through diatomaceous earth. 4. The filtrate was concentrated under vacuum to give 25.5 g of 3-methoxy-2-methylaniline as a light purple oil (Yield: quantitative). Rf value: 0.38 (hexane: ethyl acetate = 2:1, v/v). Mass spectrum (EI, m/z): 137 (M+). 1H-NMR spectrum (CDCl3, δ ppm): 2.04-2.05 (m, 3H), 3.60 (brs, 2H), 3.80 (s, 3H), 6.33-6.37 (m, 2H), 6.94-7.01 (m, 1H).

References

[1] Patent: EP1679308, 2006, A1. Location in patent: Page/Page column 56
[2] Patent: US2009/12123, 2009, A1. Location in patent: Page/Page column 14-15
[3] Patent: WO2004/103996, 2004, A1. Location in patent: Page 38-39
[4] Patent: WO2006/7700, 2006, A1. Location in patent: Page/Page column 61
[5] Patent: US2006/19905, 2006, A1. Location in patent: Page/Page column 24

3-Methoxy-2-methylaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Methoxy-2-methylaniline manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3-Methoxy-2-methylaniline 19500-02-8
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-19

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-Methoxy-2-methylaniline 19500-02-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-06

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Methoxy-2-methylaniline 19500-02-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

19500-02-8, 3-Methoxy-2-methylanilineRelated Search:

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3-Methoxy-2-methylanilin

3-Metho

3-Methoxy-2-methylaniline&gt

3-Methoxy-2-methylanili

19500-02-8

24549-01-1

API intermediates

Anilines, Amides & Amines

Anisoles, Alkyloxy Compounds & Phenylacetates

Nitro Compounds

Drug Intermediates