ChemicalBook > CAS DataBase List > (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE

(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE

Product Name: (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE
CAS No.: 247580-43-4
Chemical Name: (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE
Synonyms: SB 328437;SB 328437 >=98% (HPLC);SB 328437, CCR3 antagonist;SB 328437 - CAS 247580-43-4 - Calbiochem;SB 328437 (DMSO solution), CCR3 antagonist;(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE;Methyl (S)-2-(1-naphthamido)-3-(4-nitrophenyl)propanoate;Methyl (2S)-2-(1-naphthoylaMino)-3-(4-nitrophenyl)propanoate;N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalaninemethylester;L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester
CBNumber: CB4283869
Molecular Formula: C21H18N2O5
Formula Weight: 378.38
MOL File: Mol file

Less

(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Property

Boiling point:: 642.9±50.0 °C(Predicted)
Density: 1.305±0.06 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: DMSO: ≥10mg/mL
pka: 12.51±0.46(Predicted)
form: White solid
color: white to tan

Less

Safety

Hazard Codes: Xn,N
Risk Statements: 22-50
Safety Statements: 60-61
WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 29677
Product name: SB 328437
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 29677
Product name: SB 328437
Packaging: 5mg
Price: $111
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0207
Product name: SB 328437
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $116
Updated: 2025/07/31

Cayman Chemical

Product number: 29677
Product name: SB 328437
Packaging: 10mg
Price: $202
Updated: 2024/03/01

Tocris

Product number: 3650
Product name: SB 328437
Purity: ≥99%(HPLC)
Packaging: 10
Price: $195
Updated: 2021/12/16

Less

(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Chemical Properties,Usage,Production

Uses

SB 328437 is a potent and selective CCR3 receptor antagonist.

Biological Activity

SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. It suppresses the Th2-mediated eosinophil infiltration in the airways.', 'SB-328437 is a potent, selective CCR-3 antagonist (IC50 = 1.6 nM). The compound blockes CCR3 agonist-induced calcium mobilization in CCR3 expressing cells with the following IC50 values: eotaxin, 38 nM; eotaxin-2, 35 nM and MCP4, 20 nM.

in vivo

SB-328437 (intraperitoneal injection; 5 g/kg; single dose) has a beneficial effect in mouse models of LPS (HY-D1056)-induced lung injury and influenza virus infection^[2].

Animal Model:	Influenza A strain pmd09 treated C57BL/6 female mice aged 8-10 weeks old (18-20 g) ^[2]
Dosage:	5 g/kg
Administration:	Intraperitoneal injection (i.p.); single dose
Result:	Reduced neutrophil recruitment to the lung alveolar space. Reduced tissue damage. Reduced lung inflammation and the expression of pro-inflammatory cytokines, Tnfa and Cxcl1. Decreased the activation level of neutrophils. Lowered the viral load in mice.

IC 50

CCR3: 4.5 nM (IC₅₀)

storage

Store at +4°C

(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Suppliers

China 60 United Kingdom 2 United States 9 Global 71

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4809
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
Email: 2853979810@qq.com
Country: China
ProdList: 9898
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 18100677375
Email: sales@szzxbio.com
Country: China
ProdList: 2993
Advantage: 58

Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
ProdList: 2742
Advantage: 58

Soochow Chirally Material Science and Technology Co.,Ltd

Tel: 0512-66834346 17751187418
Email: sales@krl-tech.com
Country: China
ProdList: 1113
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

Tianjin Xinkangyou Biotechnology Co., LTD

Tel: 19922659386
Email: niuli@tjxkys.cn
Country: China
ProdList: 2995
Advantage: 58

Hubei wei shi reagent group ltd., company

Tel: 027-59101766 13125137661
Email: 2853877621@qq.com
Country: China
ProdList: 7979
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.

Tel: 025-66061636 18013972705
Email: qqyang@aikonchem.com
Country: China
ProdList: 10151
Advantage: 58

R&D Systems, Inc

Tel: 18003437475
Fax: 1-612-656-4400
Email: rdname@qq.com
Country: China
ProdList: 6960
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Selleck Chemicals

Tel: 400-668-6834
Email: info@selleck.cn
Country: China
ProdList: 6071
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Soochow Chirally Material Science and Technology Co.,Ltd

Tel: +86-51266834346 +86-17751128648
Email: sales@krl-tech.com
Country: China
ProdList: 942
Advantage: 58

Guangzhou Squirrel Biotechnology Co., Ltd.

Tel: 17765276361
Country: CHINA
ProdList: 109
Advantage: 58

Hangzhou Haofeng Biotechnology Co., Ltd.

Tel: 057186405477
Country: CHINA
ProdList: 184
Advantage: 58

Guangzhou Ruifeng Biotechnology Co., Ltd.

Tel: 14715141318
Country: CHINA
ProdList: 181
Advantage: 58

Lucheng (Shenzhen) Technology Co., Ltd.

Tel: 13128698830
Country: CHINA
ProdList: 181
Advantage: 58

Chongqing Boer Biotechnology Co., Ltd.

Tel: 13251428727， 13368356747
Country: CHINA
ProdList: 157
Advantage: 58

Shanghai Qimin Biotechnology Co., Ltd.

Tel: 13032137268
Email: 171198252@qq.com
Country: China
ProdList: 130
Advantage: 58

Guangzhou Lucheng Biotechnology Co., Ltd.

Tel: 16620452357
Country: CHINA
ProdList: 0
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Shanghai Haoran Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 470003480@QQ.COM
Country: CHINA
ProdList: 6955
Advantage: 58

Beijing Taize Jiaye Technology Development Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6050
Advantage: 58

Dongguan Biaobiao Experimental Equipment Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6672
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6648
Advantage: 58

Shanghai Silk Dragon Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 3988
Advantage: 58

Qingdao Jieshikang Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: jskangchina@163.com
Country: CHINA
ProdList: 4980
Advantage: 58

Beijing Baiao Innovation Technology Co., Ltd.

Tel: --
Fax: --
Email: 3007606172@qq.com
Country: CHINA
ProdList: 6002
Advantage: 58

Guangzhou Weijia Technology Co., Ltd.

Tel: --
Fax: --
Email: WHIGA22@126.COM
Country: CHINA
ProdList: 6757
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6973
Advantage: 58

Beijing Huaxia Ocean Technology Co., Ltd.

Tel: --
Fax: --
Email: huaxiabio@163.com
Country: CHINA
ProdList: 6122
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6936
Advantage: 58

Beijing Bai Ao Si Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: yangmei@bioneeds.net
Country: CHINA
ProdList: 6999
Advantage: 58

Shanghai Ziqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2453006496@qq.com
Country: CHINA
ProdList: 6184
Advantage: 58

247580-43-4, (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATERelated Search:

N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA SB 204741 SB242235 SB 225002 SB 297006 SB 239063 Benzamide, N-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-4-nitro-, hydrochloride (1:1) GSK-CXCR2 SB 200646 HYDROCHLORIDE

SB 328437

(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE

SB 328437 - CAS 247580-43-4 - Calbiochem

N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalaninemethylester

Methyl (2S)-2-(1-naphthoylaMino)-3-(4-nitrophenyl)propanoate

L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester

SB 328437 >=98% (HPLC)

Methyl (S)-2-(1-naphthamido)-3-(4-nitrophenyl)propanoate

SB 328437, CCR3 antagonist

SB 328437 (DMSO solution), CCR3 antagonist

247580-43-4