N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA

Product Name: N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
CAS No.: 792173-99-0
Chemical Name: N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
Synonyms: CS-1891;SB334867/SB-334867;SB334867A free base;SB-334867,CID 6604926;SB-334867 (free base);SB-334867 >=98% (HPLC);N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl;N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA;Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-;N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
CBNumber: CB11519689
Molecular Formula: C17H13N5O2
Formula Weight: 319.32
MOL File: 792173-99-0.mol

More

Less

N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Property

Boiling point:: 450.5±30.0 °C(Predicted)
Density: 1.472
storage temp.: room temp
solubility: insoluble in H2O; insoluble in EtOH; ≥14.55 mg/mL in DMSO
pka: 10.21±0.43(Predicted)
form: powder
color: white to beige
CAS DataBase Reference: 792173-99-0

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1530
Product name: SB-334867
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $131
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1530
Product name: SB-334867
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $530
Updated: 2023/06/20

Cayman Chemical

Product number: 19145
Product name: SB-334867
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 19145
Product name: SB-334867
Packaging: 5mg
Price: $75
Updated: 2024/03/01

Cayman Chemical

Product number: 19145
Product name: SB-334867
Packaging: 10mg
Price: $138
Updated: 2024/03/01

More

Less

N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Chemical Properties,Usage,Production

Uses

SB 334867 is an orexin 1 receptor antagonist.

Definition

ChEBI: 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea is a naphthyridine derivative.

Biological Activity

sb-334867 free base is a selective antagonist of orexin-1 receptor [1].orexin-a and orexin-b are two peptides isolated from rat hypothalamus. they are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.sb-334867 free base could inhibit the orexin-a and orexin-b induced calcium responses in cho-ox1 cells with pkb values of 7.27 and 7.23, respectively. sb-334867 was more selective for ox1 receptor over ox2 receptor. it caused 32.7% and 22% inhibition of orexin-a and orexin-b induced calcium responses in cho-ox2 cells, respectively. moreover, sb-334867 was found to reduce both orexin-a-induced and fasting-induced food intake. the acute anorectic effect of it was associated with significant reductions in all active behaviours [1, 2].

Biochem/physiol Actions

Lateral hypothalamic orexin neuron activation leads to the development of morphine conditioned place preference, which is preferably blocked by SB-334867.

storage

Room temperature (desiccate)

References

[1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.
[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452.

N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Suppliers

China 63 India 1 United Kingdom 2 United States 12 Global 78

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 982
Advantage: 56

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4667
Advantage: 58

Tianjin Derchemist Science & Technology Co., Ltd.

Tel: 22-58627059 13920586291
Fax: 022-58620305
Email: zdcomcon@126.com
Country: China
ProdList: 3166
Advantage: 50

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4196
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9254
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9708
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3868
Advantage: 58

792173-99-0, N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREARelated Search:

2,6-Dichlorobenzoxazole Thianaphthene 2-(P-TOLYL)BENZOXAZOLE 2-Methylbenzothiazole Quinazoline 6-Chloro-2-benzoxazolethiol 2-Phenylbenzoxazole

1-(2-METHYL-1,3-BENZOXAZOL-6-YL)-3-(1,5-NAPHTHYRIDIN-4-YL)UREA

SB-334867,CID 6604926

SB334867/SB-334867

N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA

1-(2-methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea

SB-334867 (free base)

1-(2-Methylbenzo[d]oxazol-5-yl)-3-(1,5-naphthyridin-4-yl)urea

N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-ylurea SB334867

N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl

CS-1891

SB334867A free base

Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-

SB-334867 >=98% (HPLC)

N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA USP/EP/BP

CHO,BEC,ethanol,intake,SB334867 free base,sucrose,Hypocretin Receptor,locomotor,cell,activity,SB334867A,Orexin Receptor (OX Receptor),SB 334867 free base,HCRT Receptor,inhibit,Inhibitor

N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA

792173-99-0

Inhibitors