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L-(+)-Isoleucinol

Product Name
L-(+)-Isoleucinol
CAS No.
24629-25-2
Chemical Name
L-(+)-Isoleucinol
Synonyms
L-ISOLEUCINOL;2-amino-3-methylpentan-1-ol;H-ILE-OL;L-Ile-ol;H-L-ILE-OL;H-ISOLEUCINOL;L(+)-ISOLEUCINOL;L-Isoleucinol>(+)-L-ISOLEUCINOL;(S)-(+)-ISOLEUCINOL
CBNumber
CB4284679
Molecular Formula
C6H15NO
Formula Weight
117.19
MOL File
24629-25-2.mol
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L-(+)-Isoleucinol Property

Melting point:
36-39 °C(lit.)
Boiling point:
97 °C14 mm Hg(lit.)
alpha 
4.5 º (c=1.6, EtOH)
Density 
0.9490 (rough estimate)
refractive index 
n20/D 1.4589(lit.)
Flash point:
213 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka
12.88±0.10(Predicted)
form 
Viscous Liquid
color 
White to light yellow
optical activity
[α]20/D +4.0°, c = 1.6 in ethanol
InChI
InChI=1S/C6H15NO/c1-3-5(2)6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t5-,6+/m0/s1
InChIKey
VTQHAQXFSHDMHT-NTSWFWBYSA-N
SMILES
C(O)[C@@H](N)[C@@H](C)CC
CAS DataBase Reference
24629-25-2(CAS DataBase Reference)
NIST Chemistry Reference
(S)-(+)-Isoleucinol(24629-25-2)
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Safety

Hazard Codes 
C,Xi,Xn
Risk Statements 
34-22-40
Safety Statements 
45-36/37/39-26-36-22-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29221990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
190527
Product name
(S)-(+)-Isoleucinol
Purity
97%
Packaging
1g
Price
$28.95
Updated
2025/07/31
Sigma-Aldrich
Product number
190527
Product name
(S)-(+)-Isoleucinol
Purity
97%
Packaging
5g
Price
$145
Updated
2023/06/20
TCI Chemical
Product number
I0462
Product name
L-Isoleucinol
Purity
>97.0%(GC)(T)
Packaging
1g
Price
$102
Updated
2025/07/31
TCI Chemical
Product number
I0462
Product name
L-Isoleucinol
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$235
Updated
2025/07/31
TRC
Product number
A614678
Product name
2-Amino-3-methylpentan-1-ol
Packaging
100mg
Price
$60
Updated
2021/12/16
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L-(+)-Isoleucinol Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline solid or

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

73-32-5

24629-25-2

The general procedure for the synthesis of L-isoleucinol from L-isoleucine is as follows: the synthesis of L-isoleucinol was carried out by reference to the literature method 61 with minor adjustments. Lithium aluminum hydride (7.2 g, 0.19 mol, 2.5 eq.) was suspended in anhydrous tetrahydrofuran (120 mL) under nitrogen protection with continuous stirring. Subsequently, L-isoleucine (10 g, 0.08 mol) was added in batches and the reaction suspension was heated to reflux for 20 hours. Upon completion of the reaction, it was cooled to room temperature, ethyl acetate was added slowly and the reaction mixture was carefully poured into concentrated sodium hydroxide solution. The organic layer was extracted with water and the organic phase was subsequently dried with sodium sulfate. Removal of the solvent under reduced pressure gave 4.5 g of L-isoleucinol as a yellow oil, which could be used in subsequent reactions without further purification. The product was characterized by 1H NMR (400 MHz, CDCl3) with the following chemical shifts: δ 0.75-0.90 (6H, m), 1.01-1.17 (1H, m), 1.22-1.36 (1H, m), 1.37-1.50 (1H, m), 2.48 (2H, br s), 2.50-2.65 (1H, m), 3.19 -3.29 (1H, m), 3.57 (1H, dd, J = 3.27,10.64Hz) ppm.

References

[1] Synthetic Communications, 1996, vol. 26, # 4, p. 703 - 706
[2] Russian Chemical Bulletin, 2008, vol. 57, # 9, p. 1981 - 1988
[3] Helvetica Chimica Acta, 2004, vol. 87, # 1, p. 90 - 105
[4] Journal of Organic Chemistry, 1993, vol. 58, # 13, p. 3568 - 3571
[5] Chemical Communications, 1997, # 12, p. 1087 - 1088

L-(+)-Isoleucinol Preparation Products And Raw materials

Raw materials

Preparation Products

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L-(+)-Isoleucinol Suppliers

Americas 1 Austria 1 Belgium 1 Canada 1 China 191 Europe 3 France 1 Germany 8 India 9 Italy 1 Japan 5 Russia 1 Slovakia 1 South Korea 1 Switzerland 5 The Netherlands 1 United Kingdom 10 United States 44 Global 285
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from L-(+)-Isoleucinol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
L-isoleucinol 24629-25-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-05
Hebei Chuanghai Biotechnology Co., Ltd
Product
L-(+)-Isoleucinol 24629-25-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2025-03-07
Career Henan Chemical Co
Product
L-(+)-Isoleucinol 24629-25-2
Price
US $20.00/KG
Min. Order
25KG
Purity
99%
Supply Ability
100kg
Release date
2018-07-30

24629-25-2, L-(+)-IsoleucinolRelated Search:

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  • (2S,3S)-2-AMINO-3-METHYL-PENTAN-1-OL
  • (2S,3S)-2-AMINO-3-METHYL-1-PENTANOL
  • 2-AMINO-3-METHYL-1-PENTANOL
  • (S)-(+)-Isoleucinol,(2S,3S)-2-Amino-3-methyl-1-pentanol, L-Isoleucinol
  • (S)-(+)-Isoleucinol 97%
  • (S)-(-)-2-aMino-3-Methylpentan-1-ol
  • (S)-(+)-Isoleucinol, 95+%
  • L-Isoleucinol,99%e.e.
  • l-2-Amino-3-methyl-1-pentanol
  • [(2S,3S)-1-hydroxy-3-methylpentan-2-yl]ammonium
  • (+)-L-ISOLEUCINOL
  • L(+)-ISOLEUCINOL
  • L-ISOLEUCINOL
  • H-ILE-OL
  • H-L-ILE-OL
  • H-ISOLEUCINOL
  • (S)-(+)-2-AMINO-3-METHYL-1-PENTANOL
  • (S)-(+)-ISOLEUCINOL
  • (S,S)-2-AMINO-3-METHYL-1-PENTANOL
  • 1-Pentanol, 2-amino-3-methyl-, [S-(R*,R*)]-
  • 2-amino-3-methylpentan-1-ol
  • L-Ile-ol
  • (S)-(+)-ISOLEUCINOL / L-(+)-2-AMINO-3-METHYL-1-PENTANOL
  • 1-PENTANOL, 2-AMINO-3-METHYL-, (2S,3S)-
  • (2S,3S)-2-Amino-3-methyl-1-pentanol, L-Isoleucinol
  • (2S,3S)-3-Methyl-2-amino-1-pentanol
  • L(+)-Isoleucinol,97%
  • L-Isoleucinol,(2S,3S)-2-Amino-3-methyl-1-pentanol
  • L-Isoleucinol&gt
  • L-(+)-Isoleucinol USP/EP/BP
  • (<i>S</i>)-(+)-Isoleucinol
  • 24629-25-2
  • 24629-25-1
  • C2H5CHCH3CHNH2CH2OH
  • Chiral Building Blocks
  • Amino Alcohols (Chiral)
  • Peptide Synthesis
  • Specialty Synthesis
  • Amino Alcohols
  • Amino Acid Derivatives
  • Pharmaceutical Intermediates
  • Amines
  • blocks
  • Amino Alcohols
  • Isoleucine [Ile, I]
  • Amino Alcohols (Chiral)
  • Chiral Building Blocks
  • Synthetic Organic Chemistry
  • Chiral Compound
  • Amino alcohols