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Ibandronate sodium monohydrate

Product Name
Ibandronate sodium monohydrate
CAS No.
138926-19-9
Chemical Name
Ibandronate sodium monohydrate
Synonyms
Boniva;Bonviva;Ibandrate;BM-21.0955;RPR-102289A;Ibronate Sodium;Ibadronate SodiuM;Ibandronate sodium;Boniva monohydrate;Bondronat monohydrate
CBNumber
CB4286017
Molecular Formula
C9H24NNaO8P2
Formula Weight
359.23
MOL File
138926-19-9.mol
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Ibandronate sodium monohydrate Property

Melting point:
840C (dec)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Soluble in DMSO (up to at least 25 mg/ml)
form 
solid
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference
138926-19-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
40
Safety Statements 
22-36-24/25
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21361
Product name
Ibandronate (sodium hydrate)
Purity
≥95%
Packaging
25mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
21361
Product name
Ibandronate (sodium hydrate)
Purity
≥95%
Packaging
50mg
Price
$76
Updated
2024/03/01
Cayman Chemical
Product number
21361
Product name
Ibandronate (sodium hydrate)
Purity
≥95%
Packaging
100mg
Price
$141
Updated
2024/03/01
Cayman Chemical
Product number
21361
Product name
Ibandronate (sodium hydrate)
Purity
≥95%
Packaging
250mg
Price
$312
Updated
2024/03/01
Usbiological
Product number
280375
Product name
Ibandronate sodium monohydrate
Packaging
5g
Price
$337
Updated
2021/12/16
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Ibandronate sodium monohydrate Chemical Properties,Usage,Production

Description

Ibandronate Sodium Monohydrate is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.
Ibandronate Sodium Monohydrate inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active and the biphosphonates are used in disorders affecting the skeleton such as metastatic disease, asteoporosis and Paget's. Ibandronate Sodium Monohydrate is an inhibitor of FDPS.

Chemical Properties

[1-Hydroxy-3-(methylpentylamino)-propylidene]bisphosphonic acid sodium salt is White Crystalline Powder

Uses

Inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active. Biphosphonates are used in disorders affecting the skeleton such as asteoporosis, metastatic disease, and Paget d

Uses

bone resorption inhibitor, anthypercalcemic

Uses

An inhibitor of bone resorption

Mechanism of action

The action of ibandronate on bone tissue is based on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Ibandronate inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

Pharmacokinetics

Absorption
The absorption of oral ibandronate occurs in the upper gastrointestinal tract. Plasma concentrations increase in a dose-linear manner up to 50 mg oral intake and increases nonlinearly above this dose.
Following oral dosing, the time to maximum observed plasma ibandronate concentrations ranged from 0.5 to 2 hours (median 1 hour) in fasted healthy postmenopausal women. The mean oral bioavailability of 2.5 mg ibandronate was about 0.6% compared to intravenous dosing. The extent of absorption is impaired by food or beverages (other than plain water). The oral bioavailability of ibandronate is reduced by about 90% when BONIVA is administered concomitantly with a standard breakfast in comparison with bioavailability observed in fasted subjects. There is no meaningful reduction in bioavailability when ibandronate is taken at least 60 minutes before a meal. However, both bioavailability and the effect on bone mineral density (BMD) are reduced when food or beverages are taken less than 60 minutes following an ibandronate dose.
Distribution
After absorption, ibandronate either rapidly binds to bone or is excreted into urine. In humans, the apparent terminal volume of distribution is at least 90 L, and the amount of dose removed from the circulation via the bone is estimated to be 40% to 50% of the circulating dose. In vitro protein binding in human serum was 99.5% to 90.9% over an ibandronate concentration range of 2 to 10 ng/mL in one study and approximately 85.7% over a concentration range of 0.5 to 10 ng/mL in another study.
Metabolism
There is no evidence that ibandronate is metabolized in humans.
https://www.accessdata.fda.gov

References

1) Russell (2006), Ibandronate: Pharmacology and preclinical studies; Bone 38 S7

Ibandronate sodium monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ibandronate sodium monohydrate Suppliers

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View Lastest Price from Ibandronate sodium monohydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Ibandronate sodium monohydrate 138926-19-9
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
98%-102%
Supply Ability
100kg
Release date
2021-09-17
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Ibandronate Sodium 138926-19-9
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-09-19
Shaanxi Dideu Medichem Co. Ltd
Product
Ibandronate Sodium 138926-19-9
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2020-01-16

138926-19-9, Ibandronate sodium monohydrateRelated Search:

Pamidronic acid b-Alanine, N-methyl-N-pentyl- Ibandronate Impurity 1(Ibandronate EP Impurity B) Alendronate sodium Letrozole 3,5-Bis(2-cyanoprop-2-yl)toluene INTERMEDIATE OF IBANDRONATE SODIUM N-Pentyl-β-alanine ETHYLENEDIAMINETETRAACETIC ACID TRIPOTASSIUM SALT DIHYDRATE Disodium edetate dihydrate N-DesMethyl Ibandronate SodiuM Olpadronate Sodium Ibandronate Sodium Anhydrous N-Methylpentylamine Acryloyl chloride Trisodium phosphate methyl N-(3-methoxy-3-oxopropyl)-N-methyl-beta-alaninate Tetramethyl Ibandronate

  • Ibandrate
  • Ibandromate Monosodium
  • Sodium Trihydrogen (1-Hydroxy-3-(methylpenthylamino)propylidene)diphosphonate Monohydrate
  • BM-21.0955
  • Boniva
  • Bonviva
  • IBANDRONATE SODIUM/1-HYDROXY-3-(METHYLPENTYLAMINO)PROPYLIDENE
  • Ibadronate SodiuM
  • Ibandronate Sodium (100 mg)
  • {1-hydroxy-3-[Methyl(pentyl)aMino]-1-phosphonopropyl}phosphonic acid
  • IBANDRONATE SODIUM MONOHYDRATE
  • 1-Hydroxy-3-(methylpentylamino)propylidenebisphosphonatemonosodiummonohydrate
  • [1-Hydroxy-3-(methylpentylamino)-propylidene]bisphosphonic acid sodium salt
  • Ibandronate sodium
  • IBANDRONATE SODIUM SALT
  • Ibandronate sodiuM salt Monhydrate
  • Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis-, sodium salt, hydrate (1:1:1)
  • Ibandronate Sodium (200 mg)
  • Ibandronate Sodium Hydrate
  • Ibandronate sodium monohydrate, >=99%
  • Bondronat monohydrate
  • Boniva monohydrate
  • RPR-102289A
  • Ibronate Sodium
  • [1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphonic acid sodium salt monohydrate
  • Ibandronate Sodium MonohydrateQ: What is Ibandronate Sodium Monohydrate Q: What is the CAS Number of Ibandronate Sodium Monohydrate Q: What is the storage condition of Ibandronate Sodium Monohydrate Q: What are the applications of Ibandronate Sodium Monohydrate
  • Ibandronate Sodium (1335417)
  • Sodium hydrogen(1-hydroxy-3-(methyl(pentyl)amino)-1-phosphonopropyl)phosphonate hydrate
  • 138926-19-9
  • 38926-19-9
  • C9H23NO7P2NaH2O
  • C9H24NO8NaP2
  • C9H24NNaO8P2
  • C9H22NO7P2Na
  • C9H22O7NP2NaH2O
  • C9H22NO7P2NaH2O
  • C9H22NNaO7P2H2O
  • C9H22O7NP2Na
  • C9H22NO7P2H2ONa
  • Inhibitors
  • BONIVA
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API's
  • Ibandronate
  • anti-osteoporosis
  • Bone resorption inhibitor