(S)-3-Hydroxypyrrolidine hydrochloride

Product Name: (S)-3-Hydroxypyrrolidine hydrochloride
CAS No.: 122536-94-1
Chemical Name: (S)-3-Hydroxypyrrolidine hydrochloride
Synonyms: (S)-pyrrolidin-3-ol hydrochloride;TIMTEC-BB SBB004272;(S)-3-hydroxypyrroL;(S)-3-Hydroxypyrro HCl;S-(+)-3-PyrrolidinolHCl;(S)-PYRROLIDIN-3-OL HCL;(3S)-3-Pyrrolidinol HCl;3-(S)-HYDROXYPYRROLIDINE HCL;(S)-3-HYDROXY PYRROLIDINE HCL;3(S)-3-HYDROXY-PYRROLIDINE HCL
CBNumber: CB4294344
Molecular Formula: C4H10ClNO
Formula Weight: 123.58
MOL File: 122536-94-1.mol

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(S)-3-Hydroxypyrrolidine hydrochloride Property

Melting point:: 104-107°C
Boiling point:: 108-110℃/8mm
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Sparingly), Methanol (Slightly)
form: Solid
color: Off-White to Pale Beige
Stability:: Hygroscopic
InChI: InChI=1/C4H9NO.ClH/c6-4-1-2-5-3-4;/h4-6H,1-3H2;1H/t4-;/s3
InChIKey: QPMSJEFZULFYTB-NDILARRWNA-N
SMILES: O[C@@H]1CNCC1.Cl |&1:1,r|
CAS DataBase Reference: 122536-94-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: -36/37/38
Safety Statements: 26-37
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

AstaTech

Product number: 29175
Product name: (S)-3-PYRROLIDINOL HCL
Purity: 98%
Packaging: 10G
Price: $23
Updated: 2026/04/30

Matrix Scientific

Product number: 112193
Product name: (S)-3-Hydroxypyrrolidine hydrochloride
Packaging: 25.00g
Price: $115
Updated: 2026/05/18

Matrix Scientific

Product number: 112193
Product name: (S)-3-Hydroxypyrrolidine hydrochloride
Packaging: 100.00g
Price: $388
Updated: 2026/05/18

Synthonix

Product number: H7496
Product name: (S)-3-Hydroxypyrrolidine hydrochloride
Purity: 97.0%
Packaging: 25g
Price: $30
Updated: 2026/05/06

Synthonix

Product number: H7496
Product name: (S)-3-Hydroxypyrrolidine hydrochloride
Purity: 97.0%
Packaging: 50g
Price: $60
Updated: 2026/05/06

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(S)-3-Hydroxypyrrolidine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

almost white crystalline powder

Uses

(S)-3-Hydroxypyrrolidine Hydrochloride is a useful intermediate for the synthesis of Asimadoline Hydrochlorine (A788250), used in the treatment of IBS, a disorder associated with pain and altered bowel function.

Synthesis

(3S)-N-benzyl-3-hydroxypyrrolidine-2,5-dione (100g), added to a 1L high-pressure reactor, add ethanol 500mL, add 10% palladium carbon (58% water content, model D10H5A, Shaanxi Ruike New Materials Co., Ltd.) 5g, through the hydrogen, keep the pressure of the reaction system 0.5MPa, slowly raise the temperature to 70 , the reaction for 5 hours. The reaction was completed by central control, filtered to recover the palladium carbon, concentrated the solvent, added isopropanol (200 mL) to the residue and stirred to dissolve completely, added concentrated hydrochloric acid (45 mL, 12M, 1.1eq) dropwise, stirred overnight at room temperature, and filtered to obtain a white solid, i.e., 51g of (S)-3-pyrrolidinol hydrochloride, with 85% yield and 99.1% purity.

References

[1] Patent: EP2803664, 2014, A1. Location in patent: Paragraph 0153; 0154
[2] Patent: US2015/5282, 2015, A1. Location in patent: Paragraph 0224; 0225
[3] Patent: CN105646321, 2016, A. Location in patent: Paragraph 0031; 0032

(S)-3-Hydroxypyrrolidine hydrochloride Preparation Products And Raw materials

Raw materials

L-Malic acid Ethanol Calcium chloride Acetyl chloride Benzylamine Sodium borohydride Tetrahydrofuran Ethyl acetate Lithium Aluminum Hydride Hydrochloric acid Dichloromethane Acetic acid Methanol Sodium hydroxide Petroleum ether HEAVY DISTILLATE

Preparation Products

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(S)-3-Hydroxypyrrolidine hydrochloride Suppliers

China 305 Europe 2 France 1 Germany 2 India 13 Japan 1 Slovakia 1 United Kingdom 9 United States 32 Global 366

Sichuan Argalbio Technology Co,.Ltd

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Alfa Aesar

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View Lastest Price from (S)-3-Hydroxypyrrolidine hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: (S)-3-Hydroxypyrrolidine hydrochloride 122536-94-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-29

Anhui Dexinjia Biopharm Co., Ltd

Product: (S)-3-hydroxypyrrolidine hydrochoride 122536-94-1
Price: US $600.00-20000.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 2MT per month
Release date: 2021-01-21

Shaanxi Dideu Medichem Co. Ltd

Product: (S)-3-Hydroxypyrrolidine hydrochloride 122536-94-1
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 2000tons
Release date: 2019-12-31

122536-94-1, (S)-3-Hydroxypyrrolidine hydrochlorideRelated Search:

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TIMTEC-BB SBB004272

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S-(+)-3-PyrrolidinolHCl

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(3S)-3-Hydroxypyrrolidine hydrochloride

(3S)-pyrrolidin-3-ol hydrochloride

3-Pyrrolidinol,1-[(4-Methylphenyl)sulfonyl]-, 3-(4-Methylbenzenesulfonate), (3R)-

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(S)-3-Pyrrolidinol Hydrochloride,99%e.e.

3(S)-3-HYDROXY-PYRROLIDINE HCL

(S)-3-hydroxypyrroL

Sixty. (S) - 3 - hydroxy pyrrolidine hydrochloride

(3S)-3-Pyrrolidinol hydrochloride (1:1)

(3S)-3-Pyrrolidinol HCl

3-(S)-HYDROXYPYRROLIDINE HCL

(S)-3-Pyrrolidinol hydrochloride, CAS 122536-94-1

(S)-pyrrolidin-3-ol hydrochloride

122536-94-1

C4H9NOHCl

Chiral chemicals

Benzenes

Heterocyclic Compounds

pharmacetical

Pyrrole&Pyrrolidine&Pyrroline

chiral

Alcohols and Derivatives

Intermediate

1