ChemicalBook > CAS DataBase List > (R)-(-)-3-Pyrrolidinol hydrochloride

(R)-(-)-3-Pyrrolidinol hydrochloride

Product Name
(R)-(-)-3-Pyrrolidinol hydrochloride
CAS No.
104706-47-0
Chemical Name
(R)-(-)-3-Pyrrolidinol hydrochloride
Synonyms
(R)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE;(R)-pyrrolidin-3-ol hydrochloride;(S)-3-PYRROLIDINOL HYDROCHLORIDE;(3R)-Pyrrolidin-3-ol hydrochloride;(R)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE;idinoL;(R)-(-)-3-PyrroL;TIMTEC-BB SBB004272;(R)-3-Hydroxypyrroli;(R)-pyrrolidin-3-ol HCl
CBNumber
CB6125385
Molecular Formula
C4H10ClNO
Formula Weight
123.58
MOL File
104706-47-0.mol
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(R)-(-)-3-Pyrrolidinol hydrochloride Property

Melting point:
104-107 °C(lit.)
alpha 
-7.6°(20/D, c=3,5, CH3OH)
refractive index 
-7.8 ° (C=3.5, MeOH)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in DMSO.
form 
Solid
color 
Pale Brown
optical activity
[α]20/D 7.6°, c = 3.5 in methanol
BRN 
4450078
InChIKey
QPMSJEFZULFYTB-PGMHMLKASA-N
CAS DataBase Reference
104706-47-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-41-38-37
Safety Statements 
26-36-38
WGK Germany 
3
F 
3-10
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
430722
Product name
(R)-3-Pyrrolidinol hydrochloride
Purity
98%
Packaging
1G
Price
$45
Updated
2024/03/01
Sigma-Aldrich
Product number
430722
Product name
(R)-3-Pyrrolidinol hydrochloride
Purity
98%
Packaging
10g
Price
$162
Updated
2024/03/01
TCI Chemical
Product number
P1140
Product name
(R)-(-)-3-Pyrrolidinol Hydrochloride
Purity
>98.0%(T)
Packaging
5g
Price
$101
Updated
2024/03/01
TCI Chemical
Product number
P1140
Product name
(R)-(-)-3-Pyrrolidinol Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$355
Updated
2024/03/01
Alfa Aesar
Product number
H52743
Product name
(R)-3-Hydroxypyrrolidine hydrochloride, 97%
Packaging
1g
Price
$24.5
Updated
2023/06/20
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(R)-(-)-3-Pyrrolidinol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Llight brown crystalline

Uses

(R)-3-Hydroxypyrrolidine hydrochloride is used as a darifenacin Intermediate.

Uses

(R)-3-Pyrrolidinol hydrochloride can be used as a building block to synthesize:

  • Biaryl carboxamide functional groups containing bis-aminopyrrolidine ureas as potential antagonists of the melanin-concentrating hormone receptor-1.
  • Pyrrolidinol based ionic liquids.
  • Optically active 2-tritylpyrrolidine based organocatalysts.

Uses

(R)-(-)-3-Pyrrolidinol hydrochloride is a chiral hydroxy derivative of pyrrlodine used in the preparation of chiral niologically active compounds such as muscarinic receptor antagonists and antimicrobial agents.

Purification Methods

The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]

(R)-(-)-3-Pyrrolidinol hydrochloride Preparation Products And Raw materials

Raw materials

Ethanol Calcium chloride Acetyl chloride Benzylamine Sodium borohydride Tetrahydrofuran Ethyl acetate Lithium Aluminum Hydride Hydrochloric acid Dichloromethane Cyclohexanol Acetic acid Methanol Sodium hydroxide 2-Cyclohexen-1-one L-Hydroxyproline PETROLEUM ETHER HEAVY DISTILLATE D(+)-Malic acid

Preparation Products

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(R)-(-)-3-Pyrrolidinol hydrochloride Suppliers

Americas 1 Canada 3 China 323 Europe 4 France 1 Germany 8 India 13 Japan 3 Slovakia 1 South Korea 2 Switzerland 1 United Kingdom 14 United States 53 Global 428
Chengdu Firster Pharmaceutical Co., Ltd.
Tel
028-87078428 028-87074958
Fax
8772-8116
Email
chengzhenyong@cdfirster.com
Country
China
ProdList
1989
Advantage
60
Chongqing Werlchem Fine Chemical Co.Ltd.
Tel
023-67521957 13320292971
Fax
86-23-67511575
Email
sales@werlchem.com
Country
China
ProdList
28
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62
BTC Pharmaceutical CO. Ltd
Tel
0513-0513-68015-397-397 15716293042
Fax
0513-68015394
Email
sales14@btcpharm.com
Country
China
ProdList
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Shanghai Sagachem Co., Ltd.
Tel
13816115801
Email
raochenaone@126.com
Country
China
ProdList
193
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Shanghai KeLy Bio-Pharmaceutical Co., Ltd.
Tel
13816253073
Email
lige@kelybiopharm.com
Country
China
ProdList
105
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Nanjing Joyin Pharmachem Co.,Ltd
Tel
025-84670162-813 18761603731
Email
marketing@joyin.cc
Country
China
ProdList
98
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58
Jiujiang Huayao Biotechnology Co., Ltd.
Tel
0792-13970278 13970278471
Email
36516506@qq.com
Country
China
ProdList
75
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J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
Advantage
66
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View Lastest Price from (R)-(-)-3-Pyrrolidinol hydrochloride manufacturers

Chongqing Chemdad Co.,Ltd
Product
(R)-(-)-3-Pyrrolidinol hydrochloride 104706-47-0
Price
US $200.00/KG
Min. Order
1KG
Purity
98
Supply Ability
100kg
Release date
2019-06-27
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
(R)-(-)-3-Pyrrolidinol hydrochloride 104706-47-0
Price
US $3.30/KG
Min. Order
1Kg/Bag
Purity
98%
Supply Ability
10KG
Release date
2021-09-24
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
(R)-3-Hydroxypyrrolidine HCl 104706-47-0
Price
US $3.30/KG
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2021-09-24

104706-47-0, (R)-(-)-3-Pyrrolidinol hydrochlorideRelated Search:

N-Vinyl-2-pyrrolidone Topotecan hydrochloride Polyvinylpyrrolidone Crospovidone 3-Pyrrolidinol PYRROLIDONE HYDROTRIBROMIDE N-Methyl-2-pyrrolidone Povidone iodine METHYL-2-PYRROLIDONE Scopine hydrochloride HYOSCINE HYDROCHLORIDE 3-PYRROLIDINOL HYDROCHLORIDE (S)-(-)-3-PYRROLIDINOL HYDROCHLORIDE,(S)-3-PYRROLIDINOL HYDROCHLORIDE,3-PYRROLIDINOL, HYDROCHLORIDE, (3S),(S)-(+)-3-PYRROLIDINOL HYDROCHLORIDE,98% DL-3-PYRROLIDINOL Darifenacin 3-FURANAMINE, TETRAHYDRO- (R)-3-Hydroxypyrrolidine trans-4-Hydroxy-L-proline methyl ester hydrochloride

  • (R)-(-)-3-PYRROLIDINOL HCL
  • (R)-3-Hydroxypyrrolidine hydrochloride, (R)-3-Pyrrolidinol hydrochloride
  • (3R)-Pyrrolidin-3-ol hydrochloride
  • (R)-()-3-Pyrrolidinol hydrochloride ,97%
  • (R)-3-Hydroxypyrroli
  • (3R)-3-Hydroxypyrrolidine hydrochloride
  • (R)-3-Pyrrolindinol hydrochloride
  • (R)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE
  • (R)-3-AMINOTETRAHYDROFURAN HYDROCHLORIDE
  • TIMTEC-BB SBB004272
  • (R)-(-)-3-Pyrrolidonol hydrochloride
  • (R)-(-)-3-PYRROLIDINOL HYDROCHLORIDE, 98 %
  • (R)-(-)-3-PYRROLIDINOL HYDROCHLORIDE 98%
  • (R)-pyrrolidin-3-ol hydrochloride
  • (R)-3-Hydroxypyrrolidine Hydrochloride (Darifenacin)
  • (R)-(-)-3-PyrroL
  • idinoL
  • Product naMe (R)-(-)-3-Pyrrolidinol hydrochloride
  • (R)-pyrrolidin-3-ol HCl
  • 3-Pyrrolidinol,hydrochloride (1:1), (3R)
  • (R)-(-)-3-Pyrrolidinol hydrochloride SynonyMs (R)-3-Hydroxypyrrolidine hydrochloride
  • (<i>R</i>)-(-)-3-Pyrrolidinol hydrochloride
  • (3R)-Pyrrolidin-3-ol, HCl
  • (R)-3-hydroxyp yrrolidine hydrochlorode
  • (R)-Tetrahydrofuran-3-ol hydrochloride
  • (R)-3-Pyrrolidinol Hydrochloride,99%e.e.
  • 3-PYRROLIDINOL, HYDROCHLORIDE, (3R)-
  • 3-PYRROLIDINOL, HYDROCHLORIDE, (3S)
  • 3R-HYDROXYPYROLIDINE HCL
  • 3-FURANAMINE, TETRAHYDRO-, (R)-, HYDROCHLORIDE
  • (S)-PYRROLIDIN-3-OL HCL
  • (S)-PYRROLIDINE-3-OL HYDROCHLORIDE
  • (R)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE
  • (R)-PYRROLIDINE-3-OL HYDROCHLORIDE
  • (S)-3-HYDROXY PYRROLIDINE HCL
  • (S)-(-)-3-PYRROLIDINOL HYDROCHLORIDE
  • (S)-3-PYRROLIDINOL HYDROCHLORIDE
  • (R)-(-)-3-PYRROLIDINOL HYDROCHLORIDE
  • (R)-(+)-3-PYRROLIDINOL HYDROCHLORIDE
  • (R)-3-PYRROLIDINOL HYDROCHLORIDE
  • (R)-3-HYDROXYPYRROLIDINE HCL
  • (R)-(-)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE
  • (3R)-3-Pyrrolidinol, hydrochloride (1:1)
  • (R)-(-)-3-PyrrolidinolHydrochloride&gt
  • (R) - (-) -3-pyrrolidine hydrochloride
  • (R)-(-)-3-Pyrrolidinol hydrochloride ISO 9001：2015 REACH
  • 104706-47-0 (R)-(-)-3-Pyrrolidinol hydrochloride C4H10ClNO
  • <font color="#ff0000">104706-47-0</font>
  • (3R)-3-Pyrrolidinol HCl
  • 104706-47-0
  • C4H10CINO
  • C4H9NOHClC4H10ClNO
  • C4H9NOClH
  • C4H10ClNOC4H9NOHCl
  • Chiral Building Blocks
  • Simple Alcohols (Chiral)
  • Asymmetric Synthesis
  • Heterocyclic Building Blocks