ChemicalBook > CAS DataBase List > (R)-(-)-3-Pyrrolidinol hydrochloride
(R)-(-)-3-Pyrrolidinol hydrochloride
- Product Name
- (R)-(-)-3-Pyrrolidinol hydrochloride
- CAS No.
- 104706-47-0
- Chemical Name
- (R)-(-)-3-Pyrrolidinol hydrochloride
- Synonyms
- (R)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE;(R)-pyrrolidin-3-ol hydrochloride;(S)-3-PYRROLIDINOL HYDROCHLORIDE;(3R)-Pyrrolidin-3-ol hydrochloride;(R)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE;idinoL;(R)-(-)-3-PyrroL;TIMTEC-BB SBB004272;(R)-3-Hydroxypyrroli;(R)-pyrrolidin-3-ol HCl
- CBNumber
- CB6125385
- Molecular Formula
- C4H10ClNO
- Formula Weight
- 123.58
- MOL File
- 104706-47-0.mol
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(R)-(-)-3-Pyrrolidinol hydrochloride Property
- Melting point:
- 104-107 °C(lit.)
- alpha
- -7.6°(20/D, c=3,5, CH3OH)
- refractive index
- -7.8 ° (C=3.5, MeOH)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in DMSO.
- form
- Solid
- color
- Pale Brown
- optical activity
- [α]20/D 7.6°, c = 3.5 in methanol
- BRN
- 4450078
- InChI
- InChI=1/C4H9NO.ClH/c6-4-1-2-5-3-4;/h4-6H,1-3H2;1H/t4-;/s3
- InChIKey
- QPMSJEFZULFYTB-PGMHMLKASA-N
- SMILES
- [C@H]1(O)CNCC1.Cl |&1:0,r|
- CAS DataBase Reference
- 104706-47-0(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-41-38-37
- Safety Statements
- 26-36-38
- WGK Germany
- 3
- F
- 3-10
- HS Code
- 29339900
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 430722
- Product name
- (R)-3-Pyrrolidinol hydrochloride
- Purity
- 98%
- Packaging
- 1G
- Price
- $45
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 430722
- Product name
- (R)-3-Pyrrolidinol hydrochloride
- Purity
- 98%
- Packaging
- 10g
- Price
- $162
- Updated
- 2024/03/01
TCI Chemical
- Product number
- P1140
- Product name
- (R)-(-)-3-Pyrrolidinol Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $101
- Updated
- 2024/03/01
TCI Chemical
- Product number
- P1140
- Product name
- (R)-(-)-3-Pyrrolidinol Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $355
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- H52743
- Product name
- (R)-3-Hydroxypyrrolidine hydrochloride, 97%
- Packaging
- 1g
- Price
- $24.5
- Updated
- 2023/06/20
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(R)-(-)-3-Pyrrolidinol hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Llight brown crystalline
Uses
(R)-3-Hydroxypyrrolidine hydrochloride is used as a darifenacin Intermediate.
Uses
(R)-3-Pyrrolidinol hydrochloride can be used as a building block to synthesize:
- Biaryl carboxamide functional groups containing bis-aminopyrrolidine ureas as potential antagonists of the melanin-concentrating hormone receptor-1.
- Pyrrolidinol based ionic liquids.
- Optically active 2-tritylpyrrolidine based organocatalysts.
Uses
(R)-(-)-3-Pyrrolidinol hydrochloride is a chiral hydroxy derivative of pyrrlodine used in the preparation of chiral niologically active compounds such as muscarinic receptor antagonists and antimicrobial agents.
Purification Methods
The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]
(R)-(-)-3-Pyrrolidinol hydrochloride Preparation Products And Raw materials
Raw materials
Ethanol
Calcium chloride
Acetyl chloride
Benzylamine
Sodium borohydride
Tetrahydrofuran
Ethyl acetate
Lithium Aluminum Hydride
Hydrochloric acid
Dichloromethane
Cyclohexanol
Acetic acid
Methanol
Sodium hydroxide
2-Cyclohexen-1-one
L-Hydroxyproline
PETROLEUM ETHER
HEAVY DISTILLATE
D(+)-Malic acid
Preparation Products
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(R)-(-)-3-Pyrrolidinol hydrochloride Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
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View Lastest Price from (R)-(-)-3-Pyrrolidinol hydrochloride manufacturers
Hebei Ganmiao New material Technology Co., LTD
- Product
- (R)-(-)-3-Pyrrolidinol hydrochloride 104706-47-0
- Price
- US $10.00-7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-06-05
Hebei Fengjia New Material Co., Ltd
- Product
- (R)-(-)-3-Pyrrolidinol hydrochloride 104706-47-0
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000000
- Release date
- 2024-08-15
Chongqing Chemdad Co.,Ltd
- Product
- (R)-(-)-3-Pyrrolidinol hydrochloride 104706-47-0
- Price
- US $200.00/KG
- Min. Order
- 1KG
- Purity
- 98
- Supply Ability
- 100kg
- Release date
- 2019-06-27
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