ChemicalBook > CAS DataBase List > (R)-(-)-3-Pyrrolidinol hydrochloride

(R)-(-)-3-Pyrrolidinol hydrochloride

Product Name
(R)-(-)-3-Pyrrolidinol hydrochloride
CAS No.
104706-47-0
Chemical Name
(R)-(-)-3-Pyrrolidinol hydrochloride
Synonyms
(R)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE;(R)-pyrrolidin-3-ol hydrochloride;(S)-3-PYRROLIDINOL HYDROCHLORIDE;(3R)-Pyrrolidin-3-ol hydrochloride;(R)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE;idinoL;(R)-(-)-3-PyrroL;TIMTEC-BB SBB004272;(R)-3-Hydroxypyrroli;(R)-pyrrolidin-3-ol HCl
CBNumber
CB6125385
Molecular Formula
C4H10ClNO
Formula Weight
123.58
MOL File
104706-47-0.mol
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(R)-(-)-3-Pyrrolidinol hydrochloride Property

Melting point:
104-107 °C(lit.)
alpha 
-7.6°(20/D, c=3,5, CH3OH)
refractive index 
-7.8 ° (C=3.5, MeOH)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in DMSO.
form 
Solid
color 
Pale Brown
optical activity
[α]20/D 7.6°, c = 3.5 in methanol
BRN 
4450078
InChI
InChI=1/C4H9NO.ClH/c6-4-1-2-5-3-4;/h4-6H,1-3H2;1H/t4-;/s3
InChIKey
QPMSJEFZULFYTB-PGMHMLKASA-N
SMILES
[C@H]1(O)CNCC1.Cl |&1:0,r|
CAS DataBase Reference
104706-47-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-41-38-37
Safety Statements 
26-36-38
WGK Germany 
3
F 
3-10
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
430722
Product name
(R)-3-Pyrrolidinol hydrochloride
Purity
98%
Packaging
1G
Price
$45
Updated
2024/03/01
Sigma-Aldrich
Product number
430722
Product name
(R)-3-Pyrrolidinol hydrochloride
Purity
98%
Packaging
10g
Price
$162
Updated
2024/03/01
TCI Chemical
Product number
P1140
Product name
(R)-(-)-3-Pyrrolidinol Hydrochloride
Purity
>98.0%(T)
Packaging
5g
Price
$101
Updated
2024/03/01
TCI Chemical
Product number
P1140
Product name
(R)-(-)-3-Pyrrolidinol Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$355
Updated
2024/03/01
Alfa Aesar
Product number
H52743
Product name
(R)-3-Hydroxypyrrolidine hydrochloride, 97%
Packaging
1g
Price
$24.5
Updated
2023/06/20
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(R)-(-)-3-Pyrrolidinol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Llight brown crystalline

Uses

(R)-3-Hydroxypyrrolidine hydrochloride is used as a darifenacin Intermediate.

Uses

(R)-3-Pyrrolidinol hydrochloride can be used as a building block to synthesize:

  • Biaryl carboxamide functional groups containing bis-aminopyrrolidine ureas as potential antagonists of the melanin-concentrating hormone receptor-1.
  • Pyrrolidinol based ionic liquids.
  • Optically active 2-tritylpyrrolidine based organocatalysts.

Uses

(R)-(-)-3-Pyrrolidinol hydrochloride is a chiral hydroxy derivative of pyrrlodine used in the preparation of chiral niologically active compounds such as muscarinic receptor antagonists and antimicrobial agents.

Purification Methods

The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]

(R)-(-)-3-Pyrrolidinol hydrochloride Preparation Products And Raw materials

Raw materials

Ethanol Calcium chloride Acetyl chloride Benzylamine Sodium borohydride Tetrahydrofuran Ethyl acetate Lithium Aluminum Hydride Hydrochloric acid Dichloromethane Cyclohexanol Acetic acid Methanol Sodium hydroxide 2-Cyclohexen-1-one L-Hydroxyproline PETROLEUM ETHER HEAVY DISTILLATE D(+)-Malic acid

Preparation Products

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(R)-(-)-3-Pyrrolidinol hydrochloride Suppliers

Americas 1 Canada 3 China 341 Europe 4 France 1 Germany 8 India 13 Japan 3 Slovakia 1 South Korea 2 Switzerland 1 United Kingdom 14 United States 52 Global 445
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
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NovoChemy Ltd.
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021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
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ACTIVATE SCIENTIFIC GmbH
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info@activate-scientific.com
Country
Germany
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Karl H. Boddin Chemiehandel GmbH
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Germany
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Service Chemical Inc.
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sales@chemos-group.com
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Germany
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ABCR GmbH & CO. KG
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info@abcr.de
Country
Germany
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Degussa AG
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degussa-bk@degussa.com
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Germany
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PARAGOS
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Germany
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View Lastest Price from (R)-(-)-3-Pyrrolidinol hydrochloride manufacturers

Hebei Ganmiao New material Technology Co., LTD
Product
(R)-(-)-3-Pyrrolidinol hydrochloride 104706-47-0
Price
US $10.00-7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-05
Hebei Fengjia New Material Co., Ltd
Product
(R)-(-)-3-Pyrrolidinol hydrochloride 104706-47-0
Price
US $120.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1000000
Release date
2024-08-15
Chongqing Chemdad Co.,Ltd
Product
(R)-(-)-3-Pyrrolidinol hydrochloride 104706-47-0
Price
US $200.00/KG
Min. Order
1KG
Purity
98
Supply Ability
100kg
Release date
2019-06-27

104706-47-0, (R)-(-)-3-Pyrrolidinol hydrochlorideRelated Search:

N-Vinyl-2-pyrrolidone Topotecan hydrochloride Polyvinylpyrrolidone Crospovidone 3-Pyrrolidinol PYRROLIDONE HYDROTRIBROMIDE N-Methyl-2-pyrrolidone Povidone iodine METHYL-2-PYRROLIDONE Scopine hydrochloride HYOSCINE HYDROCHLORIDE 3-PYRROLIDINOL HYDROCHLORIDE (S)-(-)-3-PYRROLIDINOL HYDROCHLORIDE,(S)-3-PYRROLIDINOL HYDROCHLORIDE,3-PYRROLIDINOL, HYDROCHLORIDE, (3S),(S)-(+)-3-PYRROLIDINOL HYDROCHLORIDE,98% DL-3-PYRROLIDINOL Darifenacin 3-FURANAMINE, TETRAHYDRO- (R)-3-Hydroxypyrrolidine trans-4-Hydroxy-L-proline methyl ester hydrochloride

  • (R)-(-)-3-PYRROLIDINOL HCL
  • (R)-3-Hydroxypyrrolidine hydrochloride, (R)-3-Pyrrolidinol hydrochloride
  • (3R)-Pyrrolidin-3-ol hydrochloride
  • (R)-()-3-Pyrrolidinol hydrochloride ,97%
  • (R)-3-Hydroxypyrroli
  • (3R)-3-Hydroxypyrrolidine hydrochloride
  • (R)-3-Pyrrolindinol hydrochloride
  • (R)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE
  • (R)-3-AMINOTETRAHYDROFURAN HYDROCHLORIDE
  • TIMTEC-BB SBB004272
  • (R)-(-)-3-Pyrrolidonol hydrochloride
  • (R)-(-)-3-PYRROLIDINOL HYDROCHLORIDE, 98 %
  • (R)-(-)-3-PYRROLIDINOL HYDROCHLORIDE 98%
  • (R)-pyrrolidin-3-ol hydrochloride
  • (R)-3-Hydroxypyrrolidine Hydrochloride (Darifenacin)
  • (R)-(-)-3-PyrroL
  • idinoL
  • Product naMe (R)-(-)-3-Pyrrolidinol hydrochloride
  • (R)-pyrrolidin-3-ol HCl
  • 3-Pyrrolidinol,hydrochloride (1:1), (3R)
  • (R)-(-)-3-Pyrrolidinol hydrochloride SynonyMs (R)-3-Hydroxypyrrolidine hydrochloride
  • (<i>R</i>)-(-)-3-Pyrrolidinol hydrochloride
  • (3R)-Pyrrolidin-3-ol, HCl
  • (R)-3-hydroxyp yrrolidine hydrochlorode
  • (R)-Tetrahydrofuran-3-ol hydrochloride
  • (R)-3-Pyrrolidinol Hydrochloride,99%e.e.
  • 3-PYRROLIDINOL, HYDROCHLORIDE, (3R)-
  • 3-PYRROLIDINOL, HYDROCHLORIDE, (3S)
  • 3R-HYDROXYPYROLIDINE HCL
  • 3-FURANAMINE, TETRAHYDRO-, (R)-, HYDROCHLORIDE
  • (S)-PYRROLIDIN-3-OL HCL
  • (S)-PYRROLIDINE-3-OL HYDROCHLORIDE
  • (R)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE
  • (R)-PYRROLIDINE-3-OL HYDROCHLORIDE
  • (S)-3-HYDROXY PYRROLIDINE HCL
  • (S)-(-)-3-PYRROLIDINOL HYDROCHLORIDE
  • (S)-3-PYRROLIDINOL HYDROCHLORIDE
  • (R)-(-)-3-PYRROLIDINOL HYDROCHLORIDE
  • (R)-(+)-3-PYRROLIDINOL HYDROCHLORIDE
  • (R)-3-PYRROLIDINOL HYDROCHLORIDE
  • (R)-3-HYDROXYPYRROLIDINE HCL
  • (R)-(-)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE
  • (3R)-3-Pyrrolidinol, hydrochloride (1:1)
  • (R)-(-)-3-PyrrolidinolHydrochloride&gt
  • (R) - (-) -3-pyrrolidine hydrochloride
  • (R)-(-)-3-Pyrrolidinol hydrochloride ISO 9001：2015 REACH
  • 104706-47-0 (R)-(-)-3-Pyrrolidinol hydrochloride C4H10ClNO
  • <font color="#ff0000">104706-47-0</font>
  • (3R)-3-Pyrrolidinol HCl
  • (3R)-3-Pyrrolidinol hydrochloride
  • 104706-47-0
  • C4H10CINO
  • C4H9NOHClC4H10ClNO
  • C4H9NOClH
  • C4H10ClNOC4H9NOHCl
  • Chiral Building Blocks
  • Simple Alcohols (Chiral)
  • Asymmetric Synthesis