(R)-(-)-3-Pyrrolidinol hydrochloride

ChemicalBook > CAS DataBase List > (R)-(-)-3-Pyrrolidinol hydrochloride

(R)-(-)-3-Pyrrolidinol hydrochloride

Product Name: (R)-(-)-3-Pyrrolidinol hydrochloride
CAS No.: 104706-47-0
Chemical Name: (R)-(-)-3-Pyrrolidinol hydrochloride
Synonyms: (R)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE;(R)-pyrrolidin-3-ol hydrochloride;(S)-3-PYRROLIDINOL HYDROCHLORIDE;(3R)-Pyrrolidin-3-ol hydrochloride;(R)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE;idinoL;(R)-(-)-3-PyrroL;TIMTEC-BB SBB004272;(R)-3-Hydroxypyrroli;(R)-pyrrolidin-3-ol HCl
CBNumber: CB6125385
Molecular Formula: C4H10ClNO
Formula Weight: 123.58
MOL File: 104706-47-0.mol

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(R)-(-)-3-Pyrrolidinol hydrochloride Property

Melting point:: 104-107 °C(lit.)
alpha: -7.6°(20/D, c=3,5, CH3OH)
refractive index: -7.8 ° (C=3.5, MeOH)
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO.
form: Solid
color: Pale Brown
optical activity: [α]20/D 7.6°, c = 3.5 in methanol
BRN: 4450078
InChIKey: QPMSJEFZULFYTB-PGMHMLKASA-N
CAS DataBase Reference: 104706-47-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-41-38-37
Safety Statements: 26-36-38
WGK Germany: 3
F: 3-10
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 430722
Product name: (R)-3-Pyrrolidinol hydrochloride
Purity: 98%
Packaging: 1G
Price: $45
Updated: 2024/03/01

Sigma-Aldrich

Product number: 430722
Product name: (R)-3-Pyrrolidinol hydrochloride
Purity: 98%
Packaging: 10g
Price: $162
Updated: 2024/03/01

TCI Chemical

Product number: P1140
Product name: (R)-(-)-3-Pyrrolidinol Hydrochloride
Purity: >98.0%(T)
Packaging: 5g
Price: $101
Updated: 2024/03/01

TCI Chemical

Product number: P1140
Product name: (R)-(-)-3-Pyrrolidinol Hydrochloride
Purity: >98.0%(T)
Packaging: 25g
Price: $355
Updated: 2024/03/01

Alfa Aesar

Product number: H52743
Product name: (R)-3-Hydroxypyrrolidine hydrochloride, 97%
Packaging: 1g
Price: $24.5
Updated: 2023/06/20

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(R)-(-)-3-Pyrrolidinol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Llight brown crystalline

Uses

(R)-3-Hydroxypyrrolidine hydrochloride is used as a darifenacin Intermediate.

Uses

(R)-3-Pyrrolidinol hydrochloride can be used as a building block to synthesize:

Biaryl carboxamide functional groups containing bis-aminopyrrolidine ureas as potential antagonists of the melanin-concentrating hormone receptor-1.
Pyrrolidinol based ionic liquids.
Optically active 2-tritylpyrrolidine based organocatalysts.

Uses

(R)-(-)-3-Pyrrolidinol hydrochloride is a chiral hydroxy derivative of pyrrlodine used in the preparation of chiral niologically active compounds such as muscarinic receptor antagonists and antimicrobial agents.

Purification Methods

The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]

(R)-(-)-3-Pyrrolidinol hydrochloride Preparation Products And Raw materials

Raw materials

Ethanol Calcium chloride Acetyl chloride Benzylamine Sodium borohydride Tetrahydrofuran Ethyl acetate Lithium Aluminum Hydride Hydrochloric acid Dichloromethane Cyclohexanol Acetic acid Methanol Sodium hydroxide 2-Cyclohexen-1-one L-Hydroxyproline PETROLEUM ETHER HEAVY DISTILLATE D(+)-Malic acid

Preparation Products

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View Lastest Price from (R)-(-)-3-Pyrrolidinol hydrochloride manufacturers

Chongqing Chemdad Co.,Ltd

Product: (R)-(-)-3-Pyrrolidinol hydrochloride 104706-47-0
Price: US $200.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 100kg
Release date: 2019-06-27

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: (R)-(-)-3-Pyrrolidinol hydrochloride 104706-47-0
Price: US $3.30/KG
Min. Order: 1Kg/Bag
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: (R)-3-Hydroxypyrrolidine HCl 104706-47-0
Price: US $3.30/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-24

104706-47-0, (R)-(-)-3-Pyrrolidinol hydrochlorideRelated Search:

N-Vinyl-2-pyrrolidone Topotecan hydrochloride Polyvinylpyrrolidone Crospovidone 3-Pyrrolidinol PYRROLIDONE HYDROTRIBROMIDE N-Methyl-2-pyrrolidone Povidone iodine METHYL-2-PYRROLIDONE Scopine hydrochloride HYOSCINE HYDROCHLORIDE 3-PYRROLIDINOL HYDROCHLORIDE (S)-(-)-3-PYRROLIDINOL HYDROCHLORIDE,(S)-3-PYRROLIDINOL HYDROCHLORIDE,3-PYRROLIDINOL, HYDROCHLORIDE, (3S),(S)-(+)-3-PYRROLIDINOL HYDROCHLORIDE,98% DL-3-PYRROLIDINOL Darifenacin 3-FURANAMINE, TETRAHYDRO- (R)-3-Hydroxypyrrolidine trans-4-Hydroxy-L-proline methyl ester hydrochloride

(R)-(-)-3-PYRROLIDINOL HCL

(R)-3-Hydroxypyrrolidine hydrochloride, (R)-3-Pyrrolidinol hydrochloride

(3R)-Pyrrolidin-3-ol hydrochloride

(R)-()-3-Pyrrolidinol hydrochloride ,97%

(R)-3-Hydroxypyrroli

(3R)-3-Hydroxypyrrolidine hydrochloride

(R)-3-Pyrrolindinol hydrochloride

(R)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE

(R)-3-AMINOTETRAHYDROFURAN HYDROCHLORIDE

TIMTEC-BB SBB004272

(R)-(-)-3-Pyrrolidonol hydrochloride

(R)-(-)-3-PYRROLIDINOL HYDROCHLORIDE, 98 %

(R)-(-)-3-PYRROLIDINOL HYDROCHLORIDE 98%

(R)-pyrrolidin-3-ol hydrochloride

(R)-3-Hydroxypyrrolidine Hydrochloride (Darifenacin)

(R)-(-)-3-PyrroL

idinoL

Product naMe (R)-(-)-3-Pyrrolidinol hydrochloride

(R)-pyrrolidin-3-ol HCl

3-Pyrrolidinol,hydrochloride (1:1), (3R)

(R)-(-)-3-Pyrrolidinol hydrochloride SynonyMs (R)-3-Hydroxypyrrolidine hydrochloride

(<i>R</i>)-(-)-3-Pyrrolidinol hydrochloride

(3R)-Pyrrolidin-3-ol, HCl

(R)-3-hydroxyp yrrolidine hydrochlorode

(R)-Tetrahydrofuran-3-ol hydrochloride

(R)-3-Pyrrolidinol Hydrochloride,99%e.e.

3-PYRROLIDINOL, HYDROCHLORIDE, (3R)-

3-PYRROLIDINOL, HYDROCHLORIDE, (3S)

3R-HYDROXYPYROLIDINE HCL

3-FURANAMINE, TETRAHYDRO-, (R)-, HYDROCHLORIDE

(S)-PYRROLIDIN-3-OL HCL

(S)-PYRROLIDINE-3-OL HYDROCHLORIDE

(R)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE

(R)-PYRROLIDINE-3-OL HYDROCHLORIDE

(S)-3-HYDROXY PYRROLIDINE HCL

(S)-(-)-3-PYRROLIDINOL HYDROCHLORIDE

(S)-3-PYRROLIDINOL HYDROCHLORIDE

(R)-(-)-3-PYRROLIDINOL HYDROCHLORIDE

(R)-(+)-3-PYRROLIDINOL HYDROCHLORIDE

(R)-3-PYRROLIDINOL HYDROCHLORIDE

(R)-3-HYDROXYPYRROLIDINE HCL

(R)-(-)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE

(3R)-3-Pyrrolidinol, hydrochloride (1:1)

(R)-(-)-3-PyrrolidinolHydrochloride&gt

(R) - (-) -3-pyrrolidine hydrochloride

(R)-(-)-3-Pyrrolidinol hydrochloride ISO 9001：2015 REACH

104706-47-0 (R)-(-)-3-Pyrrolidinol hydrochloride C4H10ClNO

(3R)-3-Pyrrolidinol HCl

104706-47-0

C4H10CINO

C4H9NOHClC4H10ClNO

C4H9NOClH

C4H10ClNOC4H9NOHCl

Chiral Building Blocks

Simple Alcohols (Chiral)

Asymmetric Synthesis

Heterocyclic Building Blocks