(S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine
- Product Name
- (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine
- CAS No.
- 1227163-84-9
- Chemical Name
- (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine
- Synonyms
- CS-2630;(S)-AZD3839;AZD3839 fuMarate;AZD3839 (free base);AZD3839;AZD-3839;AZD 3839;AZD3839 free base, 10 mM in DMSO;(S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine;1H-Isoindol-3-amine, 1-[2-(difluoromethyl)-4-pyridinyl]-4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-, (1S)-;AZD3839 free base,β-Secretase,BACE,AZD-3839 free base,inhibit,AZD 3839,AZD-3839,Beta-secretase,Inhibitor;(S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine AZD3839
- CBNumber
- CB42995920
- Molecular Formula
- C24H16F3N5
- Formula Weight
- 431.41
- MOL File
- 1227163-84-9.mol
(S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine Property
- Boiling point:
- 596.3±60.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 125 mg/mL (289.75 mM; Need ultrasonic)
- form
- Powder
- pka
- 2.56±0.40(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 28388
- Product name
- AZD3839
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 28388
- Product name
- AZD3839
- Packaging
- 25mg
- Price
- $479
- Updated
- 2024/03/01
- Product number
- 28388
- Product name
- AZD3839
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 28388
- Product name
- AZD3839
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- CS-5933
- Product name
- AZD3839freebase
- Purity
- 99.99%
- Packaging
- 10mg
- Price
- $240
- Updated
- 2021/12/16
(S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine Chemical Properties,Usage,Production
Biological Activity
AZD3839 is a potent and selective BACE1 inhibitor (Ki = 26.1 nM/BACE1, 372.4 nM/BACE2, >25 μM/Cathepsin D by cell-free TR-FRET; hERG IC50 = 4.8 μM) th at effectively suppresses cellular BACE1 activity in neuron cultures (sAPPβ release IC50 = 16.7 nM/SH-SY5Y; Aβ40 release IC50 = 4.8 nM/SH-SY5Y AAP695wt, 32.2 nM/N2A, 24.8 nM/guinea pig cortical neurons, 51 nM/murine cortical neurons) and exhibits in vivo Aβ40-, Aβ42-, sAPPβ-reducing efficacy (80 & 160 μmol/kg mouse, p.o.; 100 & 200 μmol/kg guinea pigs, p.o., 2.5 & 20 μmol/kg cynomolgus monkeys, i.v.) with good pharmacokinetic properties and oral availability.
(S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine Suppliers
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- Fax
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- Country
- India
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