ML346

Product Name: ML346
CAS No.: 100872-83-1
Chemical Name: ML346
Synonyms: ML346;CS-2056;ML346;ML 346;ML346 - CID 767276;5-(3-(4-Methoxyphenyl)allylidene)pyrimidine-2,4,6(1H,3H,5H)-trione;2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]-;response,inhibit,probe,protein,Heat shock proteins,Inhibitor,ML346,ML 346,HSP,shock,conformational,cytotoxicity,ML-346,heat,chaperones
CBNumber: CB43041431
Molecular Formula: C14H12N2O4
Formula Weight: 272.26
MOL File: 100872-83-1.mol

More

Less

ML346 Property

Melting point:: 266-268 °C(Solv: ethyl acetate (141-78-6))
Density: 1.374±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO:8.0(Max Conc. mg/mL);29.38(Max Conc. mM)
form: A crystalline solid
pka: 7.42±0.20(Predicted)
color: Pink to red

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 23844
Product name: ML-346
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 23844
Product name: ML-346
Purity: ≥98%
Packaging: 5mg
Price: $108
Updated: 2024/03/01

Cayman Chemical

Product number: 23844
Product name: ML-346
Purity: ≥98%
Packaging: 10mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 23844
Product name: ML-346
Purity: ≥98%
Packaging: 25mg
Price: $266
Updated: 2024/03/01

Axon Medchem

Product number: Axon2703
Product name: ML346-CID767276
Purity: 100%
Packaging: 10mg
Price: $137.5
Updated: 2021/12/16

More

Less

ML346 Chemical Properties,Usage,Production

Description

ML-346 is an activator of the heat shock response that induces the expression of the heat shock proteins HSP70, HSP40, and HSP27. It induces the expression of the oxidative stress response genes HO1, GCLM, and BiP in mouse embryonic fibroblasts (MEFs) and pretreatment protects cells from severe heat shock-induced death and H₂O₂-induced apoptosis. It promotes folding of metastable proteins in models of conformational disease, including cellular models of Huntingtin aggregation and cystic fibrosis. It reduces aggregate formation in PC12 cells expressing human Huntingtin exon 1 containing a 74 glutamine expansion when used at a concentration of 10 μM. It also corrects trafficking of cystic fibrosis transmembrane conductance regulator proteins bearing the F508 deletion (ΔF508-CFTR) mutation carried by the majority of cystic fibrosis patients, leading to increased cell surface expression.

ML346 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ML346 Suppliers

China 44 United States 10 Global 54

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Axon Medchem LLC

Tel: --
Fax: --
Email: info@axonmedchem.com
Country: United States
ProdList: 763
Advantage: 58

100872-83-1, ML346Related Search:

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML-228 ML188 (Racemate) ML 18 ML-098 ML277 ML 204 ML329 ML364 VU0456810 ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML-327 PTP1B-IN-2 ML264

ML346;ML 346

ML346 - CID 767276

CS-2056

ML346

2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]-

5-(3-(4-Methoxyphenyl)allylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

response,inhibit,probe,protein,Heat shock proteins,Inhibitor,ML346,ML 346,HSP,shock,conformational,cytotoxicity,ML-346,heat,chaperones

100872-83-1