Thiophene-2-sulfonamide
- Product Name
- Thiophene-2-sulfonamide
- CAS No.
- 6339-87-3
- Chemical Name
- Thiophene-2-sulfonamide
- Synonyms
- BUTTPARK 44\07-11;2-Thienylsulfonamide;2-thiophenesulfonamide;Thiophene-Α-Sulfonamide;THIOPHENE-A-SULFONAMIDE;THIOPHENE-2-SULFONAMIDE;Thiophene-2-sulphonamide;THIOPHENE-ALPHA-SULFONAMIDE;THIOPHENE-2-SULFONIC ACID AMIDE;2-Thiophenesulfonamide(6CI,7CI,8CI,9CI)
- CBNumber
- CB4308056
- Molecular Formula
- C4H5NO2S2
- Formula Weight
- 163.22
- MOL File
- 6339-87-3.mol
Thiophene-2-sulfonamide Property
- Melting point:
- 137-141 °C
- Boiling point:
- 338.1±34.0 °C(Predicted)
- Density
- 1.513±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 9.94±0.60(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- 1S/C4H5NO2S2/c5-9(6,7)4-2-1-3-8-4/h1-3H,(H2,5,6,7)
- InChIKey
- KTFDYVNEGTXQCV-UHFFFAOYSA-N
- SMILES
- NS(=O)(=O)c1cccs1
- CAS DataBase Reference
- 6339-87-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 706655
- Product name
- 2-Thiophenesulfonamide
- Purity
- 96%
- Packaging
- 1g
- Price
- $57.7
- Updated
- 2023/06/20
- Product number
- 706655
- Product name
- 2-Thiophenesulfonamide
- Purity
- 96%
- Packaging
- 5g
- Price
- $184
- Updated
- 2023/06/20
- Product number
- T2851
- Product name
- 2-Thiophenesulfonamide
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- T2851
- Product name
- 2-Thiophenesulfonamide
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $106
- Updated
- 2025/07/31
- Product number
- T344858
- Product name
- Thiophene-2-sulfonamide
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
Thiophene-2-sulfonamide Chemical Properties,Usage,Production
Definition
ChEBI: 2-Thiophenesulfonamide is a member of thiophenes.
Synthesis Reference(s)
Tetrahedron Letters, 35, p. 7201, 1994 DOI: 10.1016/0040-4039(94)85360-6
Synthesis
16629-19-9
6339-87-3
General procedure for the synthesis of 2-thiophenesulfonamide from 2-thiophenesulfonyl chloride: Example: preparation of 2-thiophenesulfonamide 2-Thiophenesulfonyl chloride (0.5 g, 2.74 mmol) was added to 25% ammonium hydroxide solution (5 mL, 33.45 mmol), refluxed and stirred at 50°C for 15 hours. Upon completion of the reaction, the reaction mixture was filtered while hot and the residue was washed with boiling aqueous 25% ammonium hydroxide solution. Subsequently, the ammonium hydroxide solution was removed by vacuum distillation until there was no ammonia odor. Eventually, 2-thiophenesulfonamide was recrystallized from water to give a white solid (0.328 g, 77% yield). Product Characterization: Melting point: 145-146°C; IR spectrum (KBr, cm?1): 3290 (N-H stretching vibration), 3224 (N-H stretching vibration); NMR hydrogen spectrum (400 MHz, DMSO-d6, δ): 7.15 (1H, dd, J = 5.0, 3.7 Hz, C(4)H), 7.55 (1H, dd, J = 3.7, 1.4 Hz, C(3)H), 7.66 (2H, s, NH2), 7.85 (1H, dd, J = 5.0, 1.4 Hz, C(5)H); NMR carbon spectrum (100 MHz, DMSO-d6, δ): 127.3, 130.0, 131.1, 145.7; Mass spectrum (ESI?): m/z 162 ([M-H]? , 100%); High-resolution mass spectrum (ESI?): C4H4NO2S2 ([M-H]?) Calculated value 161.9689, measured value 161.9695.
References
[1] Journal of the American Chemical Society, 2010, vol. 132, # 10, p. 3238 - 3239
[2] Patent: WO2011/55142, 2011, A2. Location in patent: Page/Page column 47
[3] Phosphorus and Sulfur and the Related Elements, 1981, vol. 10, p. 111 - 120
[4] Phosphorus and Sulfur and the Related Elements, 1980, vol. 8, p. 197 - 200
[5] Justus Liebigs Annalen der Chemie, 1933, vol. 501, p. 174,182
Thiophene-2-sulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Thiophene-2-sulfonamide manufacturers
- Product
- 2-Thiophenesulfonamide 6339-87-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-02-03