2-Thiazolecarboxamidine Hydrochloride
- Product Name
- 2-Thiazolecarboxamidine Hydrochloride
- CAS No.
- 247037-82-7
- Chemical Name
- 2-Thiazolecarboxamidine Hydrochloride
- Synonyms
- EOS-60665;2-Thiazolecarboxamidine;2-Thiazolecarboxamidine,HCl;2-ThiazolecarboxiMidaMide HCl;THIAZOLE-2-CARBOXIMIDAMIDE HCL;2-Thiazolecarboxamidine Hydrochloride;Thiazole-2-carboxamidine hydrochloride;2-ThiazolecarboxiMidaMide hydrochloride;Thiazole-2-carboxiMidaMide hydrochloride;2-Thiazolecarboximidamide monohydrochloride
- CBNumber
- CB12520699
- Molecular Formula
- C4H6ClN3S
- Formula Weight
- 163.62
- MOL File
- 247037-82-7.mol
2-Thiazolecarboxamidine Hydrochloride Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C4H5N3S.ClH/c5-3(6)4-7-1-2-8-4;/h1-2H,(H3,5,6);1H
- InChIKey
- MOIIOZOJYWYXEP-UHFFFAOYSA-N
- SMILES
- C(C1SC=CN=1)(N)=N.Cl
- CAS DataBase Reference
- 247037-82-7
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T344313
- Product name
- Thiazole-2-carboximidamideHydrochloride
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- J95633
- Product name
- Thiazole-2-carboximidamidehydrochloride
- Packaging
- 10g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 7H41-5-01
- Product name
- 1,3-Thiazole-2-carboximidamidehydrochloride
- Packaging
- 5G
- Price
- $450
- Updated
- 2021/12/16
- Product number
- 7H41-5-01
- Product name
- 1,3-Thiazole-2-carboximidamidehydrochloride
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- A149561
- Product name
- Thiazole-2-carboximidamidehydrochloride
- Purity
- 97%
- Packaging
- 25g
- Price
- $149
- Updated
- 2021/12/16
2-Thiazolecarboxamidine Hydrochloride Chemical Properties,Usage,Production
Synthesis
1452-16-0
247037-82-7
General procedure for the synthesis of 2-thiazolecarboxamidine hydrochloride from 2-cyanothiazole: Methanol (12 L) was added to a SQL reactor, followed by 2-cyanothiazole (2200 g, 20.00 mol, 1 eq.) and sodium methanolate (54 g, 1 mol, 0.05 eq.). The mixture was stirred at 10°C for 0.5 hours. The course of the reaction was monitored by TLC (petroleum ether: ethyl acetate = 2:1) to confirm the disappearance of the feedstock and to detect the formation of intermediates. Next, ammonium chloride (1296 g, 24.00 mol, 1.2 eq.) was added and the mixture was stirred at 65 °C for 16 hours. The disappearance of the intermediate was again confirmed by TLC (petroleum ether: ethyl acetate = 2:1) indicating completion of the reaction. The reaction mixture was filtered to remove solid ammonium chloride (210 g) and the filtrate was dried to give the crude product. The crude product was slurried with ethyl acetate (20 L) for 2 h and then filtered to give 2-thiazolecarboxamidine hydrochloride (3200 g) with 98% purity. The effective content was 95% as determined by quantitative NMR. The isolated yield was 93%.1H NMR (400 MHz, DMSO-d6) δ 8.26 (d, J = 2.76 Hz, 1H), 8.38 (d, J = 3.01 Hz, 1H), 9.81 (br.s., 1H).LCMS: m/z 127.9 [M + H]+.
References
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 8, p. 3352 - 3371
[2] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 9, p. 969 - 974
[3] Patent: US2018/312512, 2018, A1. Location in patent: Paragraph 0091; 0092; 0100; 0101; 0102; 0103
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 1, p. 299 - 301
[5] Patent: WO2014/37480, 2014, A1. Location in patent: Page/Page column 91; 92
2-Thiazolecarboxamidine Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
2-Thiazolecarboxamidine Hydrochloride Suppliers
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 0531-61320525 15866703830
- figo.gao@foxmail.com
- Country
- China
- ProdList
- 5178
- Advantage
- 58
- Tel
- 0512-63970158-603 18018108880
- Fax
- 0512-63971078
- info@lakestarpharma.com
- Country
- China
- ProdList
- 421
- Advantage
- 59
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 28-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 510
- Advantage
- 57
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 025-52161033 15312098939
- Fax
- 025-83254025
- sales@njdrschem.com
- Country
- China
- ProdList
- 583
- Advantage
- 64
View Lastest Price from 2-Thiazolecarboxamidine Hydrochloride manufacturers
- Product
- 2-Thiazolecarboxamidine Hydrochloride 247037-82-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-11-11
- Product
- 2-Thiazolecarboxamidine Hydrochloride 247037-82-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 2-Thiazolecarboxamidine Hydrochloride 247037-82-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-06