2-Thiopheneacetyl chloride
- Product Name
- 2-Thiopheneacetyl chloride
- CAS No.
- 39098-97-0
- Chemical Name
- 2-Thiopheneacetyl chloride
- Synonyms
- SKL1309;AKOS BBS-00003919;2-ThiopheneacetyL;TIMTEC-BB SBB006705;2-Thiopheneacetyl ch;Articaine Impurity 2;Articaine Impurity 11;2-THIENYLACETYL CHLORIDE;Articaine Impurities1823;Thien-2-ylacetyl chloride
- CBNumber
- CB3152140
- Molecular Formula
- C6H5ClOS
- Formula Weight
- 160.62
- MOL File
- 39098-97-0.mol
2-Thiopheneacetyl chloride Property
- Boiling point:
- 105-106 °C/22 mmHg (lit.) 130-135 °C/90 mmHg (lit.)
- Density
- 1.303 g/mL at 25 °C (lit.)
- vapor pressure
- 4 mm Hg ( 83 °C)
- refractive index
- n20/D 1.551(lit.)
- Flash point:
- 215 °F
- storage temp.
- 2-8°C
- form
- Liquid
- color
- Clear brown
- Specific Gravity
- 1.303
- Water Solubility
- Reacts with water.
- Sensitive
- Moisture Sensitive
- BRN
- 114547
- InChIKey
- AJYXPNIENRLELY-UHFFFAOYSA-N
- CAS DataBase Reference
- 39098-97-0(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Thiopheneacetyl chloride (39098-97-0)
Safety
- Hazard Codes
- C
- Risk Statements
- 14-34-37-29
- Safety Statements
- 26-28-36/37/39-45-8-30-23
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- F
- 8-10-21
- TSCA
- T
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 195995
- Product name
- 2-Thiopheneacetyl chloride
- Purity
- 98%
- Packaging
- 25g
- Price
- $51.78
- Updated
- 2024/03/01
- Product number
- 8.41865
- Product name
- Thiophene-2-acetyl chloride
- Purity
- for synthesis
- Packaging
- 25ML
- Price
- $225
- Updated
- 2022/05/15
- Product number
- T1751
- Product name
- Thiophene-2-acetyl Chloride
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $85
- Updated
- 2024/03/01
- Product number
- T1751
- Product name
- Thiophene-2-acetyl Chloride
- Purity
- >98.0%(GC)(T)
- Packaging
- 250g
- Price
- $469
- Updated
- 2024/03/01
- Product number
- L09323
- Product name
- 2-Thiopheneacetyl chloride, 98%
- Packaging
- 25g
- Price
- $67.65
- Updated
- 2024/03/01
2-Thiopheneacetyl chloride Chemical Properties,Usage,Production
Description
2-Thiopheneacetyl chloride is used as a reagent to synthesize diamide derivatives of (S)-BINOL. These derivatives display potential anti-inflammatory and anti-arthritis effects. 2-Thiopheneacetyl chloride is also used in the synthesis of Nitrocefin (N493815), a chromogenic substrate that changes colour in the presence of β-lactamases and penicillin-binding proteins.
Chemical Properties
CLEAR BROWN LIQUID
Uses
2-Thiopheneacetyl chloride was used in the synthesis of (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, nipecotate-containing immunopotentiator, 5-fluorouracil-cephalosporin prodrug, series of new N,N?-di(thiopheneacetyl)diamines derivatives and 6-β-(thiophen-2?-yl)acetamidomorphine. Also used in the synthesis of Nitrocefin.
Uses
2-Thiopheneacetyl chloride was used in the synthesis of:
- (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, nipecotate-containing immunopotentiator
- 5-fluorouracil-cephalosporin prodrug
- series of new N,N′-di(thiopheneacetyl)diamines derivatives
- 6-β-(thiophen-2′-yl)acetamidomorphine
General Description
A clear yellow to dark brown liquid. Insoluble in water and denser than water. Corrosive to skin, and eyes. Vapors severely irritate respiratory tract.
Air & Water Reactions
Insoluble in water. Decomposes exothermically in water yielding fumes of toxic hydrogen chloride.
Reactivity Profile
THIOPHENE-2-ACETYL CHLORIDE is incompatible with water, bases (including amines), with strong oxidizing agents, and with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Synthesis
In the four-hole boiling flask with mechanical stirring, thermometer, air guide outlet, add 100g 2-thiophene acetic acid; 350g methylene dichloride, stirs and is warming up to 37 DEG C, starts to drip 250g sulfur oxychloride under the protection of nitrogen; within 1.5 hours, drip off insulation reaction 2.5 hours at this temperature.The methylene dichloride of underpressure distillation remnants, continues to distill obtaining 2-thiophen acetyl chloride 102.5g, and yield reaches 91.5%.
2-Thiopheneacetyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Thiopheneacetyl chloride manufacturers
- Product
- 2-Thiopheneacetyl chloride 39098-97-0
- Price
- US $68.00/Kg/Drum
- Min. Order
- 500KG
- Purity
- 98% and 99%
- Supply Ability
- 10,000kg per month
- Release date
- 2021-07-28
- Product
- 2-Thiopheneacetyl chloride 39098-97-0
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2023-03-27
- Product
- 2-Thiopheneacetyl chloride 39098-97-0
- Price
- US $6.00-0.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-24