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2-Thiopheneacetyl chloride

Product Name
2-Thiopheneacetyl chloride
CAS No.
39098-97-0
Chemical Name
2-Thiopheneacetyl chloride
Synonyms
SKL1309;AKOS BBS-00003919;2-ThiopheneacetyL;TIMTEC-BB SBB006705;2-Thiopheneacetyl ch;Articaine Impurity 2;Articaine Impurity 11;2-thiophenyl chloride;2-THIENYLACETYL CHLORIDE;Articaine Impurities1823
CBNumber
CB3152140
Molecular Formula
C6H5ClOS
Formula Weight
160.62
MOL File
39098-97-0.mol
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2-Thiopheneacetyl chloride Property

Boiling point:
105-106 °C/22 mmHg (lit.) 130-135 °C/90 mmHg (lit.)
Density 
1.303 g/mL at 25 °C (lit.)
vapor pressure 
4 mm Hg ( 83 °C)
refractive index 
n20/D 1.551(lit.)
Flash point:
215 °F
storage temp. 
2-8°C
form 
Liquid
color 
Clear brown
Specific Gravity
1.303
Water Solubility 
Reacts with water.
Sensitive 
Moisture Sensitive
BRN 
114547
InChIKey
AJYXPNIENRLELY-UHFFFAOYSA-N
CAS DataBase Reference
39098-97-0(CAS DataBase Reference)
EPA Substance Registry System
2-Thiopheneacetyl chloride (39098-97-0)
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Safety

Hazard Codes 
C
Risk Statements 
14-34-37-29
Safety Statements 
26-28-36/37/39-45-8-30-23
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
8-10-21
TSCA 
T
HazardClass 
8
PackingGroup 
III
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
195995
Product name
2-Thiopheneacetyl chloride
Purity
98%
Packaging
25g
Price
$51.78
Updated
2024/03/01
Sigma-Aldrich
Product number
8.41865
Product name
Thiophene-2-acetyl chloride
Purity
for synthesis
Packaging
25ML
Price
$225
Updated
2022/05/15
TCI Chemical
Product number
T1751
Product name
Thiophene-2-acetyl Chloride
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$85
Updated
2024/03/01
TCI Chemical
Product number
T1751
Product name
Thiophene-2-acetyl Chloride
Purity
>98.0%(GC)(T)
Packaging
250g
Price
$469
Updated
2024/03/01
Alfa Aesar
Product number
L09323
Product name
2-Thiopheneacetyl chloride, 98%
Packaging
25g
Price
$67.65
Updated
2024/03/01
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2-Thiopheneacetyl chloride Chemical Properties,Usage,Production

Description

2-Thiopheneacetyl chloride is used as a reagent to synthesize diamide derivatives of (S)-BINOL. These derivatives display potential anti-inflammatory and anti-arthritis effects. 2-Thiopheneacetyl chloride is also used in the synthesis of Nitrocefin (N493815), a chromogenic substrate that changes colour in the presence of β-lactamases and penicillin-binding proteins.

Chemical Properties

CLEAR BROWN LIQUID

Uses

2-Thiopheneacetyl chloride was used in the synthesis of (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, nipecotate-containing immunopotentiator, 5-fluorouracil-cephalosporin prodrug, series of new N,N?-di(thiopheneacetyl)diamines derivatives and 6-β-(thiophen-2?-yl)acetamidomorphine. Also used in the synthesis of Nitrocefin.

Uses

2-Thiopheneacetyl chloride was used in the synthesis of:

  • (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, nipecotate-containing immunopotentiator
  • 5-fluorouracil-cephalosporin prodrug
  • series of new N,N′-di(thiopheneacetyl)diamines derivatives
  • 6-β-(thiophen-2′-yl)acetamidomorphine

General Description

A clear yellow to dark brown liquid. Insoluble in water and denser than water. Corrosive to skin, and eyes. Vapors severely irritate respiratory tract.

Air & Water Reactions

Insoluble in water. Decomposes exothermically in water yielding fumes of toxic hydrogen chloride.

Reactivity Profile

THIOPHENE-2-ACETYL CHLORIDE is incompatible with water, bases (including amines), with strong oxidizing agents, and with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Synthesis

In the four-hole boiling flask with mechanical stirring, thermometer, air guide outlet, add 100g 2-thiophene acetic acid; 350g methylene dichloride, stirs and is warming up to 37 DEG C, starts to drip 250g sulfur oxychloride under the protection of nitrogen; within 1.5 hours, drip off insulation reaction 2.5 hours at this temperature.The methylene dichloride of underpressure distillation remnants, continues to distill obtaining 2-thiophen acetyl chloride 102.5g, and yield reaches 91.5%.

2-Thiopheneacetyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Thiopheneacetyl chloride Suppliers

MDP ChemControl Ltd.
Tel
--
Fax
--
Email
chemcontrol@nextra.sk
Country
Slovakia
ProdList
6700
Advantage
60
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View Lastest Price from 2-Thiopheneacetyl chloride manufacturers

Great Innovation (Shanghai) Pharma Co., Ltd.,
Product
2-Thiopheneacetyl chloride 39098-97-0
Price
US $68.00/Kg/Drum
Min. Order
500KG
Purity
98% and 99%
Supply Ability
10,000kg per month
Release date
2021-07-28
Hebei Weibang Biotechnology Co., Ltd
Product
2-Thiopheneacetyl chloride 39098-97-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-19
Hebei Yanxi Chemical Co., Ltd.
Product
2-Thiopheneacetyl chloride 39098-97-0
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-07

39098-97-0, 2-Thiopheneacetyl chlorideRelated Search:


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  • Appearance White crystalline powder Content 99 Melting point 153-156 Specific Rotation -16-19
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  • 2-Thiopheneacetyl chloride ISO 9001:2015 REACH
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