ChemicalBook > CAS DataBase List > Retinyl acetate

Retinyl acetate

Product Name
Retinyl acetate
CAS No.
127-47-9
Chemical Name
Retinyl acetate
Synonyms
VITAMIN A ACETATE;RETINOL ACETATE;retinyl;VITAMIN A ACETAT;RETINOL ACETATE ALL TRANS;ALL-TRANS-RETINYL ACETATE;Myvak;Myvax;Crystalets;VitaMin A ace
CBNumber
CB4308339
Molecular Formula
C22H32O2
Formula Weight
328.49
MOL File
127-47-9.mol
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Retinyl acetate Property

Melting point:
57-58 °C
Boiling point:
406.22°C (rough estimate)
Density 
1.0474 (rough estimate)
refractive index 
1.547-1.555
Flash point:
14℃
storage temp. 
2-8°C
solubility 
absolute ethanol: 25 mg/mL
form 
solid or viscous liquid
color 
Yellow powder
Odor
Amine like
biological source
synthetic (organic)
Water Solubility 
soluble
Sensitive 
Light & Air Sensitive & Hygroscopic
Merck 
14,10013
BRN 
1915439
Specific Activity
475,000-650,000USP units/g
Stability:
Hygroscopic, Light Sensitive
InChIKey
QGNJRVVDBSJHIZ-QHLGVNSISA-N
LogP
9.4 at 25℃
CAS DataBase Reference
127-47-9(CAS DataBase Reference)
NIST Chemistry Reference
Retinol, acetate(127-47-9)
EPA Substance Registry System
Retinol acetate (127-47-9)
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Safety

Hazard Codes 
Xn,Xi,T,F
Risk Statements 
38-63-36/37/38-53-61-11
Safety Statements 
36/37-45-37/39-26-53-16
RIDADR 
UN1170 - class 3 - PG 2 - Ethanol
WGK Germany 
2
RTECS 
VH6825000
F 
1-8-10
TSCA 
Yes
HS Code 
29362100
Toxicity
LD50 (10 day) orally in mice: 4100 mg/kg (Kamm)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H360May damage fertility or the unborn child

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
V-040
Product name
Retinyl acetate solution
Purity
100?μg/mL in ethanol (with 0.1% (w/v) BHT; degassed), reference material, Cerilliant?
Packaging
1mL
Price
$108
Updated
2025/07/31
Sigma-Aldrich
Product number
R0300000
Product name
Retinol acetate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
500 mg
Price
$236
Updated
2025/07/31
Sigma-Aldrich
Product number
46958
Product name
Retinyl acetate
Purity
analytical standard
Packaging
100mg
Price
$138.7
Updated
2025/07/31
Sigma-Aldrich
Product number
1716002
Product name
Retinyl acetate
Purity
United States Pharmacopeia (USP) Reference Standard, solution of retinyl acetate (vitamin A) in peanut oil
Packaging
5x0.5g
Price
$351
Updated
2025/07/31
Sigma-Aldrich
Product number
1716002
Product name
Retinyl acetate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
10x0.5g
Price
$410
Updated
2022/05/15
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Retinyl acetate Chemical Properties,Usage,Production

Description

Retinyl acetate (retinol acetate, vitamin A acetate,127-47-9) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent.

Chemical Properties

Retinyl acetate is a yellow, prism-shaped crystal and a lipid-soluble compound, with better chemical stability than vitamin A. In clinical practice, either vitamin A acetate or its palmitate form is typically dissolved in vegetable oil for administration, where it is hydrolyzed by enzymes in the body to release active vitamin A. The form of vitamin A listed in the Chinese Pharmacopoeia refers to the active vitamin A compound.

Uses

Essential micronutrient

Uses

vitamin precursor

Uses

Retinyl acetate has been used:

  • a control diet to study its effect at different developmental periods in fish larvae
  • to study its inhibitory effects on Mycobacterium avium?subspecies?paratuberculosis?(MAP) strains
  • as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk

Preparation

A method for preparing retinyl acetate the following steps:
Under alkaline conditions, 3-methyl-4-oxo-2-butene-1-yl acetate (referred to as C5 aldehyde ester) and tetraethyl methylene diphosphate undergo a condensation reaction to form an intermediate C6 phosphate (chemical name: 5-(diethyl phosphate)-3-methyl-2,4-hexadiene-1-acetate).
Under alkaline conditions, the C6 phosphate undergoes a transposition reaction. C14 aldehyde (chemical name: 2-methyl-4-(2,6,6-trimethyl-1-cyclohexene-1-yl)-3-butene-1-aldehyde) is then added to undergo a Wittig-Horner condensation reaction, yielding retinyl acetate.

Definition

ChEBI: Retinyl acetate is an acetate ester. It is functionally related to an all-trans-retinol.

General Description

Retinyl acetate is suitable for use in the retention identification of the analyte when using HPLC and GC. Not intended for use as an activity reference standard. It has been thoroughly evaluated to ensure the utmost quality. Neat, unless otherwise noted. Certificate of Composition provided with the purchase.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as required. Retinyl acetate is used in a wide range of biological applications. It acts as a chemopreventive agent. Retinyl acetate also has antineoplastic property.

Safety Profile

Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also VITAMIN A.

Purification Methods

The acetate is separated from retinol by column chromatography, then crystallised from MeOH. [Kofler and Rubin Vitamins and Hormones (NY) 18 315 1960 for purification methods]. Store it in the dark, under N2 or Ar, at 0o. [Beilstein 6 IV 4135.]

References

[1] Volker Bühler, Vademecum for Vitamin Formulations, 2001, ISBN 3-8047-1834-5
[2] SUNATDA ARAYACHUKEAT Thapakorn T U Supason P Wanichwecharungruang. Retinyl acetate-loaded nanoparticles: Dermal penetration and release of the retinyl acetate[J]. International Journal of Pharmaceutics, 2011, 404 1: Pages 281-288. DOI:10.1016/j.ijpharm.2010.11.019.
[3] HARRISON E H. Lipases and carboxylesterases: possible roles in the hepatic metabolism of retinol.[J]. Annual review of nutrition, 1998, 18: 259-276. DOI:10.1146/annurev.nutr.18.1.259.
[4] GERSTER H. Vitamin A–functions, dietary requirements and safety in humans.[J]. International Journal for Vitamin and Nutrition Research, 1997, 67 2: 71-90.
[5] https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/

Retinyl acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Retinyl acetate Suppliers

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View Lastest Price from Retinyl acetate manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Retinyl Acetate 127-47-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-12-02
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Retinyl acetate 127-47-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
500kg/month
Release date
2021-07-19
Hebei Chuanghai Biotechnology Co., Ltd
Product
Retinyl acetate 127-47-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-25

127-47-9, Retinyl acetateRelated Search:

PHENYL ACETATE POLY(VINYL ACETATE) Benzyl acetate Triacetin 1-Methoxy-2-propyl acetate Glatiramer acetate DL-α-Tocopherol Vinyl acetate Potassium Acetate 2-Butoxyethyl acetate Methyl acetate INDOPHENOL ACETATE STARCH ACETATE Ethylene glycol diacetate Tocopherol Isopropyl acetate Sodium acetate Vitamin A

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  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-4,6,8-nonatetraen- 1-ol Acetate
  • all-trans-Retinol Acetat
  • VitaMin A ace
  • Retinyl (Retinol) Acetate
  • VITAMINAACETATE(1,000,0001U/G)
  • VITAMINAACETATE(1,500,0001U/G)
  • VITAMINAACETATE(1,700,0001U/G)
  • VITAMINAACETATE(2,000,0001U/G)
  • VITAMINAACETATE(2,500,0001U/G)
  • VITAMINAACETATE(2,800,0001U/G)
  • VITAMINAACETATE,FEED,POWDER(1,000,0001U/G)
  • VITAMINAACETATE,FEED,POWDER(1,500,0001U/G)
  • VITAMINAACETATE,FEED,POWDER(500,0001U/G)
  • VITAMINAACETATE,FEED,POWDER(650,0001U/G)
  • VITAMINAACETATE,FOOD,POWDER(500,0001U/G)
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  • VITAMINAACETATE,USP
  • VITAMIN A ACETATE(RETINOL ACETATE)(RG)
  • VITAMIN A ACETATE(RETINOL ACETATE)(AS)
  • Antixerophthalmic vitamin acetate
  • (2E,4E,6E,8E)
  • -3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)
  • nona-2,4,6,8-tetraen-1-yl acetate
  • Retinol acetate Vitamin A acetate all-trans Vitamin A acetate all-trans-Retinyl acetate
  • Retinal acetate
  • Vitamin A Acetate, all trans(Synthetic) 500,000 USP u/g
  • Vitamin A Acetate 1000 IU Feed Grade
  • Retinyl acetate, 2750 IU/mg
  • Water Soluble Retinyl Acetate (Vitamin A Acetate), Liposomal Retinyl Acetate, Retinyl Acetate NanoEmusion
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  • ALL-TRANS VITAMIN A ACETATE
  • 3,7-Dimethyl-9-(2,6,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol acetate
  • All-trans-retinol acetate
  • Crystalets
  • Davitan A 650
  • Myvak
  • Myvax