ChemicalBook > CAS DataBase List > Methyl 3-amino-4-methylbenzoate

Methyl 3-amino-4-methylbenzoate

Product Name
Methyl 3-amino-4-methylbenzoate
CAS No.
18595-18-1
Chemical Name
Methyl 3-amino-4-methylbenzoate
Synonyms
AKOS BB-3092;3-Amino-p-toluic;Compound Fr13901;Methyl 3-amino-4-met;Nilotinib Impurity 25;LABOTEST-BB LT00848257;Nilotinib EP Impurity B;3-Amino-4-Methylbenzoate;METHYL 3-AMINO-P-TOLUATE;3-amino-2,4-dimethylbenzoate
CBNumber
CB4316035
Molecular Formula
C9H11NO2
Formula Weight
165.19
MOL File
18595-18-1.mol
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Methyl 3-amino-4-methylbenzoate Property

Melting point:
113-117 °C(lit.)
Boiling point:
296.3±20.0 °C(Predicted)
Density 
1.132±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
3.31±0.10(Predicted)
form 
Crystalline Powder
color 
White to cream
BRN 
2088611
InChIKey
YEPWCJHMSVABPQ-UHFFFAOYSA-N
LogP
1.7 at 22℃ and pH7
CAS DataBase Reference
18595-18-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0002111
Product name
Nilotinib impurity B
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0002111
Price
$186
Updated
2023/01/07
TCI Chemical
Product number
A1432
Product name
Methyl 3-Amino-4-methylbenzoate
Purity
>98.0%(GC)
Packaging
25g
Price
$27
Updated
2024/03/01
Alfa Aesar
Product number
A15348
Product name
Methyl 3-amino-4-methylbenzoate, 97%
Packaging
5g
Price
$25.65
Updated
2024/03/01
Alfa Aesar
Product number
A15348
Product name
Methyl 3-amino-4-methylbenzoate, 97%
Packaging
25g
Price
$87.65
Updated
2024/03/01
Alfa Aesar
Product number
A15348
Product name
Methyl 3-amino-4-methylbenzoate, 97%
Packaging
100g
Price
$229.65
Updated
2024/03/01
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Methyl 3-amino-4-methylbenzoate Chemical Properties,Usage,Production

Description

Methyl 3-amino-4-methylbenzoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Chemical Properties

Beige powder

Uses

Methyl 3-Amino-4-methylbenzoate is used as a reagent in the synthesis of perfluoroalkylated indoles which are very useful in drug development. It was also used in the preparation of 4-(pyrimidin-2-ylamino) benzamide derivatives which are designed as inhibitors of hedgehog signalling pathway (target of cancer treatment).

Application

Methyl 3-amino-4-methylbenzoate can be used for:
To prepare the methyl 4-methyl-3-((4-(proparg-1-yloxy)benzyl)amino)benzoate, 4-proparg-1-yloxybenzaldehyde (16) and methyl 3-amino-4-methylbenzoate were reacted according to the method IA.
Synthesis of Methyl 4-methyl-3-((4-(2-methylthiazol-4-yl)benzoyl)amino)benzoate
Synthesis of 4-Methyl-3-((4-(2-methylthiazol-4-yl)benzoyl)amino)benzamide

Synthesis of methyl 3-(4-hydroxy-6-methyl-2-oxopyridin-1 (2H)-yl)-4-methylbenzoate
Synthesis of (5-Carbomethoxy-2-methylphenyl)(4-hydroxypheny)diazene: To a solution of 6N HC1 (6 mL) was added methyl 3-amino-4-methylbenzoate (1.62 g, 10.0 mmol). The solution was cooled in an ice-bath, and was diazotized by adding sodium nitrite (0.9 g, 12.0 mmol). To a cold solution of phenol in 21% aqueous NaOH solution (6 mL) was added diazotized solution slowly. After 20 min, the solution was acidfied by adding 4 N aqueous HC1 and was poured into the cold water, filtered, and washed with water. Recrystallization from ethanol gave the product (2.0 g, 74%) as red crystals, mp 181.3-182.2 °C.

Preparation

Synthesis of Methyl 3-amino-4-methylbenzoate: Nitro ester Methyl 4-methyl-3-nitrobenzoate (80 g, 0.410 mol) was subjected to hydrogenation in a Parr shaker in MeOH using Raney Ni as the catalyst (5 g, 20 mol %) at 50 psi for 8 hours. The catalyst was filtered off, washed thoroughly with MeOH and the combined filtrates concentrated under reduced pressure to furnish a yellow solid (65.0 g). Yield : 96% Mp : 114-5°C (lit.14 Mp 116°C)

Definition

ChEBI: Methyl 3-amino-4-methylbenzoate is a benzoate ester.

Methyl 3-amino-4-methylbenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 3-amino-4-methylbenzoate Suppliers

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View Lastest Price from Methyl 3-amino-4-methylbenzoate manufacturers

Asia Chem I and E (Jiangsu) Co Ltd
Product
Methyl 3-amino-4-methylbenzoate 18595-18-1
Price
US $106.05/Kg/Drum
Min. Order
25Kg/Drum
Purity
99.00%HPLC
Supply Ability
8tons/month
Release date
2021-09-22
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Methyl 3-amino-4-methylbenzoate 18595-18-1
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
10 tons
Release date
2021-09-30
Henan Aochuang Chemical Co.,Ltd.
Product
Methyl 3-amino-4-methylbenzoate 18595-18-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-14

18595-18-1, Methyl 3-amino-4-methylbenzoateRelated Search:

Methylparaben Kresoxim-methyl Methyl benzoate 2-Amino-4-methylbenzoic acid Methyl acetate Glycine Bensulfuron methyl Methyl 2-iodobenzoate 4-Dimethylaminobenzoic acid 6-Aminocaproic acid 4-Aminobenzoic acid METSULFURON METHYL Thiophanate-methyl Methyl acrylate 3-Amino-4-methylbenzoic acid 4-Methyl-3-nitrobenzoic acid Methyl METHYL 2-AMINO-3-METHYLBENZOATE

  • METHYL 3-AMINO-4-METHYLBENZOATE
  • METHYL 3-AMINO-P-TOLUATE
  • LABOTEST-BB LT00848257
  • 3-amino-2,4-dimethylbenzoate
  • Nilotinib Impurity 25
  • Nilotinib EP Impurity B
  • 3-Amino-p-Toluic Acid Methyl Ester 3-Amino-4-Methyl Benzoic Acid Methyl Ester
  • 3-Amino-4-Methylbenzoate
  • 3-Amino-p-toluic
  • Methyl 3-amino-4-methylbenzoate 98%
  • Methyl 3-Amion-4-Methylbenzoate
  • AKOS BB-3092
  • 3-AMINO-4-METHYLBENZOIC ACID METHYL ESTER
  • 3-AMINO-P-TOLUIC ACID METHYL ESTER
  • Methyl4-Methyl-3-Aminobenzoate
  • Methyl 3-amino-4-met
  • 3-Amino-4-methylbenzoic Acid Methyl Ester Methyl 3-Amino-p-toluate 3-Amino-p-toluic Acid Methyl Ester
  • Methyle3-amino-4-methylbenzoate
  • 5-(Methoxycarbonyl)-2-methylaniline, 2-Amino-4-(methoxycarbonyl)toluene, 5-(Methoxycarbonyl)-o-toluidine
  • Benzoic acid, 3-aMino-4-Methyl-, Methyl ester
  • Methyl-3-amino-4-methylbenozate
  • Methyl 3-Amino-4-methylbenzoate &gt
  • Methyl 3-amino-4-methylbenzoate 18595-18-1
  • Nilotinib USP Related Compound B
  • Benzoic acid, 3-amino-4-methyl-, methyl ester (9CI, ACI)
  • 3-amino-4-methyl-Benzoic acid methyl ester (9CI ACI)
  • Compound Fr13901
  • Nilotinib Hydrochloride Monohydrate EP Impurity B
  • Nilotinib Impurity 17(Nilotinib EP Impurity B)
  • 18595-18-1
  • 18585-18-1
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