Ellipticine (hydrochloride)

Product Name: Ellipticine (hydrochloride)
CAS No.: 5081-48-1
Chemical Name: Ellipticine (hydrochloride)
Synonyms: NSC 71795 (hydrochloride);Ellipticine hydrochloride, 10 mM in DMSO;Ellipticine hydrochloride(NSC 71795 hydrochloride);5,11-dimethyl-6H-pyrido[4,3-b]carbazole hydrogen chloride;Inhibitor,Ellipticine hydrochloride,Ellipticine,NSC71795,NSC 71795,NSC-71795,Topoisomerase,inhibit
CBNumber: CB43167610
Molecular Formula: C17H15ClN2
Formula Weight: 282.77
MOL File: 5081-48-1.mol

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Ellipticine (hydrochloride) Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO:4.4(Max Conc. mg/mL);15.56(Max Conc. mM)
form: A crystalline solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18742
Product name: Ellipticine (hydrochloride)
Purity: ≥98%
Packaging: 5 mg
Price: $65
Updated: 2024/03/01

Cayman Chemical

Product number: 18742
Product name: Ellipticine (hydrochloride)
Purity: ≥98%
Packaging: 10 mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 18742
Product name: Ellipticine (hydrochloride)
Purity: ≥98%
Packaging: 25 mg
Price: $223
Updated: 2024/03/01

Cayman Chemical

Product number: 18742
Product name: Ellipticine (hydrochloride)
Purity: ≥98%
Packaging: 50 mg
Price: $380
Updated: 2024/03/01

ChemScene

Product number: CS-6199
Product name: Ellipticinehydrochloride
Purity: 99.34%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

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Ellipticine (hydrochloride) Chemical Properties,Usage,Production

Uses

Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

in vivo

Ellipticine (NSC 71795) treatment results in ellipticine-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b₅ protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b₅ may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795)^[3].

IC 50

Topoisomerase II

References

[1] Stiborova M, et al. Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):13-23. DOI:10.5507/bp.2006.002
[2] Stiborova M, et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol. 2011 Jun;4(2):98-105. DOI:10.2478/v10102-011-0017-7
[3] Stiborova M, et al. The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN?) mice and pure enzymes. Int J Mol Sci. 2014 Dec 25;16(1):284-306. DOI:10.3390/ijms16010284

Ellipticine (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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Ellipticine (hydrochloride) Suppliers

China 53 India 1 United States 7 Global 61

MedChemexpress LLC

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5081-48-1, Ellipticine (hydrochloride)Related Search:

Pyridine hydrochloride Trimethylamine hydrochloride Methylamine hydrochloride Dimethylamine hydrochloride

Ellipticine hydrochloride(NSC 71795 hydrochloride)

NSC 71795 (hydrochloride)

5,11-dimethyl-6H-pyrido[4,3-b]carbazole hydrogen chloride

Inhibitor,Ellipticine hydrochloride,Ellipticine,NSC71795,NSC 71795,NSC-71795,Topoisomerase,inhibit

Ellipticine hydrochloride, 10 mM in DMSO

5081-48-1

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