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Ellipticine (hydrochloride)

Product Name
Ellipticine (hydrochloride)
CAS No.
5081-48-1
Chemical Name
Ellipticine (hydrochloride)
Synonyms
NSC 71795 (hydrochloride);Ellipticine hydrochloride, 10 mM in DMSO;Ellipticine hydrochloride(NSC 71795 hydrochloride);5,11-dimethyl-6H-pyrido[4,3-b]carbazole hydrogen chloride;Inhibitor,Ellipticine hydrochloride,Ellipticine,NSC71795,NSC 71795,NSC-71795,Topoisomerase,inhibit
CBNumber
CB43167610
Molecular Formula
C17H15ClN2
Formula Weight
282.77
MOL File
5081-48-1.mol
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Ellipticine (hydrochloride) Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO:4.4(Max Conc. mg/mL);15.56(Max Conc. mM)
form 
A crystalline solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18742
Product name
Ellipticine (hydrochloride)
Purity
≥98%
Packaging
5 mg
Price
$65
Updated
2024/03/01
Cayman Chemical
Product number
18742
Product name
Ellipticine (hydrochloride)
Purity
≥98%
Packaging
10 mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
18742
Product name
Ellipticine (hydrochloride)
Purity
≥98%
Packaging
25 mg
Price
$223
Updated
2024/03/01
Cayman Chemical
Product number
18742
Product name
Ellipticine (hydrochloride)
Purity
≥98%
Packaging
50 mg
Price
$380
Updated
2024/03/01
ChemScene
Product number
CS-6199
Product name
Ellipticinehydrochloride
Purity
99.34%
Packaging
50mg
Price
$372
Updated
2021/12/16
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Ellipticine (hydrochloride) Chemical Properties,Usage,Production

Uses

Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

in vivo

Ellipticine (NSC 71795) treatment results in ellipticine-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b5 protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b5 may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795)[3].

IC 50

Topoisomerase II

References

[1] Stiborova M, et al. Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):13-23. DOI:10.5507/bp.2006.002
[2] Stiborova M, et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol. 2011 Jun;4(2):98-105. DOI:10.2478/v10102-011-0017-7
[3] Stiborova M, et al. The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN?) mice and pure enzymes. Int J Mol Sci. 2014 Dec 25;16(1):284-306. DOI:10.3390/ijms16010284

Ellipticine (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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Ellipticine (hydrochloride) Suppliers

China 53 India 1 United States 7 Global 61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

5081-48-1, Ellipticine (hydrochloride)Related Search:

Pyridine hydrochloride Trimethylamine hydrochloride Methylamine hydrochloride Dimethylamine hydrochloride

  • Ellipticine hydrochloride(NSC 71795 hydrochloride)
  • NSC 71795 (hydrochloride)
  • 5,11-dimethyl-6H-pyrido[4,3-b]carbazole hydrogen chloride
  • Inhibitor,Ellipticine hydrochloride,Ellipticine,NSC71795,NSC 71795,NSC-71795,Topoisomerase,inhibit
  • Ellipticine hydrochloride, 10 mM in DMSO
  • 5081-48-1
  • API