3,5-Dimethylaniline Property

Melting point:

7-9 °C

Boiling point:

104-105 °C14 mm Hg(lit.)

Density 

0.972 g/mL at 25 °C(lit.)

vapor pressure 

1.3-27hPa at 20-100℃

refractive index 

n20/D 1.557(lit.)

Flash point:

200 °F

form 

Liquid

pka

pK1:4.765(+1) (25°C)

color 

Clear yellow-brown to brown

Water Solubility 

<0.1 g/100 mL at 19 ºC

Merck 

14,10084

Specific Activity

50-60 mCi/mmol

Concentration

0.1 mCi/ml

Solvent

Ethanol

BRN 

507051

InChIKey

MKARNSWMMBGSHX-UHFFFAOYSA-N

Dissociation constant

4.71-4.91 at 15-25℃

CAS DataBase Reference

108-69-0(CAS DataBase Reference)

NIST Chemistry Reference

Benzenamine, 3,5-dimethyl-(108-69-0)

EPA Substance Registry System

3,5-Dimethylaniline (108-69-0)

Safety

Hazard Codes 

T,N

Risk Statements 

23/24/25-33-51/53

Safety Statements 

28-36/37-45-61-28A

RIDADR 

UN 1711 6.1/PG 2

WGK Germany 

3

RTECS 

ZE9625000

F 

8

Hazard Note 

Toxic

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29214990

Hazardous Substances Data

108-69-0(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

3,5-Dimethylaniline Chemical Properties,Usage,Production

Chemical Properties

clear yellow-brown to brown liquid

Uses

3,5-Dimethylaniline is the reagent commonly useful in the manufacture of dyes. It undergoes polymerization in the presence of cerium(IV) sulfate as an oxidant. This compound was also employed to produce chiral packing materials for high performance liquid chromatography.

General Description

Dark brown liquid.

Air & Water Reactions

3,5-Dimethylaniline may be sensitive to prolonged exposure to air. Insoluble in water.

Reactivity Profile

3,5-XYLIDINE ignites on contact with fuming nitric acid (NTP, 1992). Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Fire Hazard

3,5-Dimethylaniline is combustible.

Safety Profile

Suspected carcinogen. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also other xylidine entries.

Purification Methods

Convert sym-xylidine to a derivative (see below) which, after recrystallisation, is decomposed with alkali to give the free base. Dry it over KOH and fractionally distil it. The acetyl derivative has m 144o, the benzoyl derivative has m 136o and the picrate has m 209o (from H2O, EtOH or 10% AcOH). [Beilstein 12 H 1131, 12 IV 2561.]