ChemicalBook > CAS DataBase List > 2-BROMO-2'-METHOXYACETOPHENONE

2-BROMO-2'-METHOXYACETOPHENONE

Product Name: 2-BROMO-2'-METHOXYACETOPHENONE
CAS No.: 31949-21-0
Chemical Name: 2-BROMO-2'-METHOXYACETOPHENONE
Synonyms: AKOS BBS-00003867;O-METHOXYPHENACYL BROMIDE;2-METHOXYPHENACYL BROMIDE;2'-METHOXYPHENACYL BROMIDE;2-Methoxyphenacylbromide97%;A-BROMO-O-METHOXYACETOPHENONE;2-Methoxyphenacyl bromide 98%;2-BROMO-2'-METHOXYACETOPHENONE;α-Bromo-2'-methoxyacetophenone;2'-Methoxy-α-bromoacetophenone
CBNumber: CB4350095
Molecular Formula: C9H9BrO2
Formula Weight: 229.07
MOL File: 31949-21-0.mol

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2-BROMO-2'-METHOXYACETOPHENONE Property

Melting point:: 43-45 °C(lit.)
Boiling point:: 130 °C1 mm Hg(lit.)
Density: 1.4921 (rough estimate)
refractive index: 1.5500 (estimate)
Flash point:: >230 °F
storage temp.: 2-8°C
form: Crystalline Powder or Crystals
color: White to off-white
Water Solubility: Insoluble in water.
Sensitive: Lachrymatory
BRN: 1938788
InChI: InChI=1S/C9H9BrO2/c1-12-9-5-3-2-4-7(9)8(11)6-10/h2-5H,6H2,1H3
InChIKey: GKNCPTLOPRDYMH-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=CC=C1OC)CBr
CAS DataBase Reference: 31949-21-0(CAS DataBase Reference)

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Safety

Hazard Codes: C,T
Risk Statements: 34
Safety Statements: 22-26-36/37/39-45
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
Hazard Note: Lachrymatory/Toxic/Keep Cold
HazardClass: 8
PackingGroup: III
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 100854
Product name: 2-Bromo-2′-methoxyacetophenone
Purity: 98%
Packaging: 5g
Price: $201
Updated: 2025/07/31

Sigma-Aldrich

Product number: 100854
Product name: 2-Bromo-2′-methoxyacetophenone
Purity: 98%
Packaging: 1g
Price: $73
Updated: 2023/06/20

Sigma-Aldrich

Product number: 100854
Product name: 2-Bromo-2′-methoxyacetophenone
Purity: 98%
Packaging: 10g
Price: $159
Updated: 2025/07/31

TRC

Product number: B687495
Product name: 2-Bromo-2''-methoxyacetophenone
Packaging: 10g
Price: $250
Updated: 2021/12/16

AK Scientific

Product number: J91259
Product name: 2-Bromo-2'-methoxyacetophenone
Packaging: 5g
Price: $34
Updated: 2021/12/16

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2-BROMO-2'-METHOXYACETOPHENONE Chemical Properties,Usage,Production

Chemical Properties

White to greyish-green crystalline powder

Uses

2-Bromo-2'-methoxyacetophenone is used as a pharmaceutical intermediate .

Preparation

Also obtained according to the procedure of Buckman (80%).

Synthesis

579-74-8

31949-21-0

The general procedure for the synthesis of o-methoxy-2-bromoacetophenone from 2'-methoxyacetophenone was as follows: copper(II) bromide (2.97 g, 6.66 mmol) was added to a two-necked round-bottomed flask equipped with a reflux condenser. Ethyl acetate (10.0 mL) was added to the flask and the mixture was stirred at 70 °C for 5 min under nitrogen protection. A solution of chloroform (10.0 mL) of 1-(2-methoxyphenyl)ethanone (0.50 g, 3.33 mmol) was slowly added, followed by refluxing the reaction mixture for 8 hours. After completion of the reaction, it was cooled to room temperature, filtered through a diatomaceous earth pad and the filter cake was washed with ethyl acetate (20 mL). The filtrate was concentrated under reduced pressure and the crude product obtained was purified by column chromatography (eluent ratio ethyl acetate:hexane = 1:4) to afford the pure o-methoxy-2-bromoacetophenone (0.73 g, 96% yield) as a brown liquid. Thin layer chromatography Rf value was 0.43 (unfolding agent ratio ethyl acetate:hexane = 1:4); 1H NMR (300 MHz, CDCl3) δ: 7.81 (1H, dd, J = 7.8, 1.8 Hz), 7.52 (1H, td, J = 7.8, 1.8 Hz), 7.05-6.96 (2H, m), 4.61 (2H, s). 3.94 (3H, s); 13C NMR (75 MHz, CDCl3) δ: 192.3, 158.8, 134.9, 131.6, 124.9, 121.2, 111.7, 56.0, 38.0.

References

[1] Bulletin of the Korean Chemical Society, 2017, vol. 38, # 12, p. 1481 - 1485
[2] Tetrahedron Letters, 2006, vol. 47, # 27, p. 4707 - 4710
[3] Tetrahedron Letters, 2009, vol. 50, # 6, p. 700 - 703
[4] Chemistry - A European Journal, 2011, vol. 17, # 28, p. 7953 - 7959
[5] Molecules, 2017, vol. 22, # 5,

2-BROMO-2'-METHOXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-2'-METHOXYACETOPHENONE Suppliers

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View Lastest Price from 2-BROMO-2'-METHOXYACETOPHENONE manufacturers

Career Henan Chemical Co

Product: 2-BROMO-2'-METHOXYACETOPHENONE 31949-21-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-03

31949-21-0, 2-BROMO-2'-METHOXYACETOPHENONERelated Search:

2'-Bromoacetophenone 2-FLUOROCYCLOHEXANONE o-Anisaldehyde 3-BROMOCHROMONE 2-BROMO-2',5'-DIMETHOXYACETOPHENONE 2-Bromo-2′,4′-dimethoxyacetophenone 2-BROMO-2'-METHOXYACETOPHENONE 3'-METHOXYPHENACYL BROMIDE 2-Bromo-4'-methoxyacetophenone 2'-Methoxyacetophenone 2-Bromoacetophenone 4-BROMO-3-METHOXYACETOPHENONE 4-BROMO-2-METHOXYACETOPHENONE 2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE 5-BROMO-2-METHOXYACETOPHENONE 2'-BROMO-5'-METHOXYACETOPHENONE 2-(DIFLUOROMETHOXY)PHENACYL BROMIDE 1-[2-(BENZYLOXY)PHENYL]-2,3-DIBROMO-3-(4-METHYLPHENYL)PROPAN-1-ONE

JR-13728, 2-Bromo-1-(2-methoxyphenyl)ethanone, 98%

2-bromo-2-methoxy-1-phenylethanone

O-METHOXYPHENACYL BROMIDE

A-BROMO-O-METHOXYACETOPHENONE

AKOS BBS-00003867

2-BROMO-2'-METHOXYACETOPHENONE

2-BROMO-1-(2-METHOXYPHENYL)ETHANONE

2'-METHOXYPHENACYL BROMIDE

2-METHOXYPHENACYL BROMIDE

alpha-Bromo-o-methoxyacetophenone

Ethanone, 2-bromo-1-(2-methoxyphenyl)-

alpha-Bromo-2'-methoxyacetophenone

alpha-Bromo-2-methoxyacetophenone

bromomethyl 2-methoxyphenyl ketone

2-Methoxyphenacyl bromide 98%

2''-METHOXY-2-BROMOACETOPHENONE

2-BROMO-2''-METHOXYACETOPHENONE 98%

α-Bromo-2'-methoxyacetophenone

1-(2-Methoxyphenyl)-2-bromoethanone

1-(Bromoacetyl)-2-methoxybenzene

2'-Methoxy-α-bromoacetophenone

2-Bromo-2'-methoxyacetophenone,98%

2-Bromo-1-(2-methoxyphenyl)ethan-1-one, 2-(Bromoacetyl)anisole, 2-Bromo-2'-methoxyacetophenone

2-Methoxyphenacylbromide97%

2-Bromo-2’-MethoxyAcetophenone

31949-21-0

Carbonyl Compounds

Building Blocks

Organic Building Blocks

Ketones