ChemicalBook > CAS DataBase List > Coumarin 120
Coumarin 120
- Product Name
- Coumarin 120
- CAS No.
- 26093-31-2
- Chemical Name
- Coumarin 120
- Synonyms
- AMC;7-AMINO-4-METHYL-2H-CHROMEN-2-ONE;7-AMINO-4-METHYLCOUMARIN;C120;AMC 7-Amino-4-Methylcoumarin;2H-1-Benzopyran-2-one, 7-amino-4-methyl-;H-MCA;C 120;7-AMC;NSC 45796
- CBNumber
- CB4354765
- Molecular Formula
- C10H9NO2
- Formula Weight
- 175.18
- MOL File
- 26093-31-2.mol
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Coumarin 120 Property
- Melting point:
- 223-226 °C (lit.)
- Boiling point:
- 306.47°C (rough estimate)
- Density
- 1.1999 (rough estimate)
- refractive index
- 1.5060 (estimate)
- storage temp.
- 2-8°C
- solubility
- Soluble in acetone (10 mg/ml) dimethyl sulfoxide (10 mg/ml) and dimethylformamide.
- form
- Crystalline Powder
- pka
- 1.89 ± 0.20, most basic, temperature: 25 °C
- color
- Beige to brown
- Sensitive
- Light Sensitive
- λmax
- 351 nm (MeOH); 342 nm (Buffer pH 7)
- BRN
- 142231
- Major Application
- For authentification; dyelasers; color display devices; inks;monitoring underlying corrosion on coated aluminum;photoinitiating systems; recording materials;semiconductor devices; dye-sensitized solar cells(DSCs); mesoporous silica fibers; SiO2 sonogelhybrid materials; textiles; waveguides;whitening agents,
- Biological Applications
- Identifyingbacteria; measuring urinary kallikrein levels;monitoring platinum(iv) reduction and platinum(ii)reactions in cancer cells; as a substrate for measuringadipinylamidases activity, aromatic amino aciddecarboxylases activity, histone deacetylasesactivity, hydrolases/esterases activity,β-lactamases activity, microbial nitroreductasesactivity, penicillin G acylases activity,proteases/proteinases/peptidases activity,glutamyltransferases activity, tryptophanasesactivity; as an effective antitubercular agent; use astemperature sensor,
- InChIKey
- GLNDAGDHSLMOKX-UHFFFAOYSA-N
- CAS DataBase Reference
- 26093-31-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Coumarin, 7-amino-4-methyl-(26093-31-2)
- EPA Substance Registry System
- 2H-1-Benzopyran-2-one, 7-amino-4-methyl- (26093-31-2)
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Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 32049000
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 257370
- Product name
- 7-Amino-4-methylcoumarin
- Purity
- 99%
- Packaging
- 100mg
- Price
- $58.9
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 164545
- Product name
- 7-Amino-4-methylcoumarin
- Packaging
- 10mg
- Price
- $90.1
- Updated
- 2024/03/01
TCI Chemical
- Product number
- M0760
- Product name
- 7-Amino-4-methylcoumarin [for HPLC Labeling]
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $135
- Updated
- 2024/03/01
TCI Chemical
- Product number
- M0760
- Product name
- 7-Amino-4-methylcoumarin [for HPLC Labeling]
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $349
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A15017
- Product name
- 7-Amino-4-methylcoumarin, 98%
- Packaging
- 1g
- Price
- $109
- Updated
- 2024/03/01
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Coumarin 120 Chemical Properties,Usage,Production
Chemical Properties
Coumarin 120 is Light yellow beige powder
Uses
Coumarin 120 is widely used fluorophore, well-known for preparing fluorogenic substrates for cystine aminopeptidase and other hydrolases. Used as reference compound in enzyme assays.
Uses
suitable for determining polygalacturonase activity
Uses
λ max 354 nm in EthanolSuitable as laser dye and used as a fluorescent labeling reagent for trace determination of enzymes.
Definition
ChEBI: Coumarin 120 is a member of 7-aminocoumarins. It has a role as a fluorochrome.
General Description
7-Amino-4-methylcoumarin (coumarin120) is an aminocoumarin laser dye that can emit laser in the range of 370-760 nm. It has three intermolecular hydrogen bonded structures with C-H···O and N-H····O.
Biochem/physiol Actions
7-Amino-4-methylcoumarin is a coumarin derivative, which serves as a fluorescence reference standard to screen protease inhibitors.
storage
+4°C
Purification Methods
Dissolve it in 5% HCl, filter and basify with 2M ammonia. The precipitate is dried in a vacuum and recrystallised from dilute EtOH. It yields a blue solution and is light sensitive. [Sigler Synthesis 614 1980, Kanaoka et al. Chem Pharm Bull Jpn 30 1485 1982, Beilstein 18/11 V 445.]
Coumarin 120 Preparation Products And Raw materials
Raw materials
Ethyl acetoacetate
Ethanol
Ethyl chloroformate
Ethyl acetate
Acetic acid
Sodium hydroxide
3-Aminophenol
PETROLEUM ETHER
Sulfuric acid
Preparation Products
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Coumarin 120 Suppliers
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View Lastest Price from Coumarin 120 manufacturers
Hebei Yanxi Chemical Co., Ltd.
- Product
- 7-Amino-4-methylcoumarin 26093-31-2
- Price
- US $10.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-09-12
Hebei Guanlang Biotechnology Co., Ltd.
- Product
- 7-Amino-4-methylcoumarin 26093-31-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-10-17
Career Henan Chemical Co
- Product
- Coumarin 120 26093-31-2
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09
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