Coumarin 120

Product Name: Coumarin 120
CAS No.: 26093-31-2
Chemical Name: Coumarin 120
Synonyms: AMC;7-AMINO-4-METHYL-2H-CHROMEN-2-ONE;7-AMINO-4-METHYLCOUMARIN;C120;AMC 7-Amino-4-Methylcoumarin;2H-1-Benzopyran-2-one, 7-amino-4-methyl-;H-MCA;C 120;7-AMC;NSC 45796
CBNumber: CB4354765
Molecular Formula: C10H9NO2
Formula Weight: 175.18
MOL File: 26093-31-2.mol

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Coumarin 120 Property

Melting point:: 223-226 °C (lit.)
Boiling point:: 306.47°C (rough estimate)
Density: 1.1999 (rough estimate)
refractive index: 1.5060 (estimate)
storage temp.: 2-8°C
solubility: Soluble in acetone (10 mg/ml) dimethyl sulfoxide (10 mg/ml) and dimethylformamide.
form: Crystalline Powder
pka: 1.89 ± 0.20, most basic, temperature: 25 °C
color: Beige to brown
Sensitive: Light Sensitive
λmax: 351 nm (MeOH); 342 nm (Buffer pH 7)
BRN: 142231
Major Application: For authentification; dyelasers; color display devices; inks;monitoring underlying corrosion on coated aluminum;photoinitiating systems; recording materials;semiconductor devices; dye-sensitized solar cells(DSCs); mesoporous silica fibers; SiO2 sonogelhybrid materials; textiles; waveguides;whitening agents,
Biological Applications: Identifyingbacteria; measuring urinary kallikrein levels;monitoring platinum(iv) reduction and platinum(ii)reactions in cancer cells; as a substrate for measuringadipinylamidases activity, aromatic amino aciddecarboxylases activity, histone deacetylasesactivity, hydrolases/esterases activity,β-lactamases activity, microbial nitroreductasesactivity, penicillin G acylases activity,proteases/proteinases/peptidases activity,glutamyltransferases activity, tryptophanasesactivity; as an effective antitubercular agent; use astemperature sensor,
InChIKey: GLNDAGDHSLMOKX-UHFFFAOYSA-N
CAS DataBase Reference: 26093-31-2(CAS DataBase Reference)
NIST Chemistry Reference: Coumarin, 7-amino-4-methyl-(26093-31-2)
EPA Substance Registry System: 2H-1-Benzopyran-2-one, 7-amino-4-methyl- (26093-31-2)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant
TSCA: Yes
HS Code: 32049000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 257370
Product name: 7-Amino-4-methylcoumarin
Purity: 99%
Packaging: 100mg
Price: $58.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 164545
Product name: 7-Amino-4-methylcoumarin
Packaging: 10mg
Price: $90.1
Updated: 2024/03/01

TCI Chemical

Product number: M0760
Product name: 7-Amino-4-methylcoumarin [for HPLC Labeling]
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $135
Updated: 2024/03/01

TCI Chemical

Product number: M0760
Product name: 7-Amino-4-methylcoumarin [for HPLC Labeling]
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $349
Updated: 2024/03/01

Alfa Aesar

Product number: A15017
Product name: 7-Amino-4-methylcoumarin, 98%
Packaging: 1g
Price: $109
Updated: 2024/03/01

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Coumarin 120 Chemical Properties,Usage,Production

Chemical Properties

Coumarin 120 is Light yellow beige powder

Uses

Coumarin 120 is widely used fluorophore, well-known for preparing fluorogenic substrates for cystine aminopeptidase and other hydrolases. Used as reference compound in enzyme assays.

Uses

suitable for determining polygalacturonase activity

Uses

λ max 354 nm in EthanolSuitable as laser dye and used as a fluorescent labeling reagent for trace determination of enzymes.

Definition

ChEBI: Coumarin 120 is a member of 7-aminocoumarins. It has a role as a fluorochrome.

General Description

7-Amino-4-methylcoumarin (coumarin120) is an aminocoumarin laser dye that can emit laser in the range of 370-760 nm. It has three intermolecular hydrogen bonded structures with C-H···O and N-H····O.

Biochem/physiol Actions

7-Amino-4-methylcoumarin is a coumarin derivative, which serves as a fluorescence reference standard to screen protease inhibitors.

storage

+4°C

Purification Methods

Dissolve it in 5% HCl, filter and basify with 2M ammonia. The precipitate is dried in a vacuum and recrystallised from dilute EtOH. It yields a blue solution and is light sensitive. [Sigler Synthesis 614 1980, Kanaoka et al. Chem Pharm Bull Jpn 30 1485 1982, Beilstein 18/11 V 445.]

Coumarin 120 Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Ethanol Ethyl chloroformate Ethyl acetate Acetic acid Sodium hydroxide 3-Aminophenol PETROLEUM ETHER Sulfuric acid

Preparation Products

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View Lastest Price from Coumarin 120 manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: 7-Amino-4-methylcoumarin 26093-31-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

Hebei Yanxi Chemical Co., Ltd.

Product: 7-Amino-4-methylcoumarin 26093-31-2
Price: US $10.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-12

Career Henan Chemical Co

Product: Coumarin 120 26093-31-2
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-09

26093-31-2, Coumarin 120Related Search:

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