ChemicalBook > CAS DataBase List > Coumarin 120

Coumarin 120

Product Name
Coumarin 120
CAS No.
26093-31-2
Chemical Name
Coumarin 120
Synonyms
AMC;7-AMINO-4-METHYL-2H-CHROMEN-2-ONE;7-AMINO-4-METHYLCOUMARIN;C120;AMC 7-Amino-4-Methylcoumarin;2H-1-Benzopyran-2-one, 7-amino-4-methyl-;H-MCA;C 120;7-AMC;NSC 45796
CBNumber
CB4354765
Molecular Formula
C10H9NO2
Formula Weight
175.18
MOL File
26093-31-2.mol
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Coumarin 120 Property

Melting point:
223-226 °C (lit.)
Boiling point:
306.47°C (rough estimate)
Density 
1.1999 (rough estimate)
refractive index 
1.5060 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in acetone (10 mg/ml) dimethyl sulfoxide (10 mg/ml) and dimethylformamide.
form 
Crystalline Powder
pka
1.89 ± 0.20, most basic, temperature: 25 °C
color 
Beige to brown
Sensitive 
Light Sensitive
λmax
351 nm (MeOH); 342 nm (Buffer pH 7)
BRN 
142231
Major Application
For authentification; dyelasers; color display devices; inks;monitoring underlying corrosion on coated aluminum;photoinitiating systems; recording materials;semiconductor devices; dye-sensitized solar cells(DSCs); mesoporous silica fibers; SiO2 sonogelhybrid materials; textiles; waveguides;whitening agents,
Biological Applications
Identifyingbacteria; measuring urinary kallikrein levels;monitoring platinum(iv) reduction and platinum(ii)reactions in cancer cells; as a substrate for measuringadipinylamidases activity, aromatic amino aciddecarboxylases activity, histone deacetylasesactivity, hydrolases/esterases activity,β-lactamases activity, microbial nitroreductasesactivity, penicillin G acylases activity,proteases/proteinases/peptidases activity,glutamyltransferases activity, tryptophanasesactivity; as an effective antitubercular agent; use astemperature sensor,
InChIKey
GLNDAGDHSLMOKX-UHFFFAOYSA-N
CAS DataBase Reference
26093-31-2(CAS DataBase Reference)
NIST Chemistry Reference
Coumarin, 7-amino-4-methyl-(26093-31-2)
EPA Substance Registry System
2H-1-Benzopyran-2-one, 7-amino-4-methyl- (26093-31-2)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-37/39
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
32049000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
257370
Product name
7-Amino-4-methylcoumarin
Purity
99%
Packaging
100mg
Price
$58.9
Updated
2024/03/01
Sigma-Aldrich
Product number
164545
Product name
7-Amino-4-methylcoumarin
Packaging
10mg
Price
$90.1
Updated
2024/03/01
TCI Chemical
Product number
M0760
Product name
7-Amino-4-methylcoumarin [for HPLC Labeling]
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$135
Updated
2024/03/01
TCI Chemical
Product number
M0760
Product name
7-Amino-4-methylcoumarin [for HPLC Labeling]
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$349
Updated
2024/03/01
Alfa Aesar
Product number
A15017
Product name
7-Amino-4-methylcoumarin, 98%
Packaging
1g
Price
$109
Updated
2024/03/01
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Coumarin 120 Chemical Properties,Usage,Production

Chemical Properties

Coumarin 120 is Light yellow beige powder

Uses

Coumarin 120 is widely used fluorophore, well-known for preparing fluorogenic substrates for cystine aminopeptidase and other hydrolases. Used as reference compound in enzyme assays.

Uses

suitable for determining polygalacturonase activity

Uses

λ max 354 nm in EthanolSuitable as laser dye and used as a fluorescent labeling reagent for trace determination of enzymes.

Definition

ChEBI: Coumarin 120 is a member of 7-aminocoumarins. It has a role as a fluorochrome.

General Description

7-Amino-4-methylcoumarin (coumarin120) is an aminocoumarin laser dye that can emit laser in the range of 370-760 nm. It has three intermolecular hydrogen bonded structures with C-H···O and N-H····O.

Biochem/physiol Actions

7-Amino-4-methylcoumarin is a coumarin derivative, which serves as a fluorescence reference standard to screen protease inhibitors.

storage

+4°C

Purification Methods

Dissolve it in 5% HCl, filter and basify with 2M ammonia. The precipitate is dried in a vacuum and recrystallised from dilute EtOH. It yields a blue solution and is light sensitive. [Sigler Synthesis 614 1980, Kanaoka et al. Chem Pharm Bull Jpn 30 1485 1982, Beilstein 18/11 V 445.]

Coumarin 120 Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Ethanol Ethyl chloroformate Ethyl acetate Acetic acid Sodium hydroxide 3-Aminophenol PETROLEUM ETHER Sulfuric acid

Preparation Products

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Coumarin 120 Suppliers

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View Lastest Price from Coumarin 120 manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
7-Amino-4-methylcoumarin 26093-31-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-29
Hebei Yanxi Chemical Co., Ltd.
Product
7-Amino-4-methylcoumarin 26093-31-2
Price
US $10.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-12
Career Henan Chemical Co
Product
Coumarin 120 26093-31-2
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-09

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