3-NITROPROPIONIC ACID
- Product Name
- 3-NITROPROPIONIC ACID
- CAS No.
- 504-88-1
- Chemical Name
- 3-NITROPROPIONIC ACID
- Synonyms
- 3-NP;bovinocidin;NSC 64266;3-NP acid;nci-c03076;hiptagenicacid;3-nitropropanoate;3-nitropropanoicaci;3-nitro-propionicaci;3-nitropropanoicacid
- CBNumber
- CB4368089
- Molecular Formula
- C3H5NO4
- Formula Weight
- 119.08
- MOL File
- 504-88-1.mol
3-NITROPROPIONIC ACID Property
- Melting point:
- 68-70 °C (lit.)
- Boiling point:
- 222.3°C (rough estimate)
- Density
- 1.6731 (rough estimate)
- refractive index
- 1.4940 (estimate)
- storage temp.
- 2-8°C
- solubility
- alcohol: 100 mg/mL, may be light yellow
- form
- powder or crystals
- pka
- 3.66±0.10(Predicted)
- color
- white to light yellow
- biological source
- synthetic
- BRN
- 1759889
- Stability:
- Stable. Incompatible with strong oxidizing agents, bases, reducing agents.
- EPA Substance Registry System
- 3-Nitropropanoic acid (504-88-1)
Safety
- Hazard Codes
- T
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- UF6220000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 504-88-1(Hazardous Substances Data)
- Toxicity
- mmo-sat 100 mg/plate IAPUDO 27,283,80
N-Bromosuccinimide Price
- Product number
- N5636
- Product name
- 3-Nitropropionic acid
- Purity
- ≥97%
- Packaging
- 1g
- Price
- $102
- Updated
- 2024/03/01
- Product number
- 164603
- Product name
- 3-Nitropropionic acid
- Packaging
- 50mg
- Price
- $85.2
- Updated
- 2024/03/01
- Product number
- 14684
- Product name
- 3-Nitropropionic Acid
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 14684
- Product name
- 3-Nitropropionic Acid
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $270
- Updated
- 2024/03/01
- Product number
- N5636
- Product name
- 3-Nitropropionic acid
- Purity
- ≥97%
- Packaging
- 10g
- Price
- $612
- Updated
- 2024/03/01
3-NITROPROPIONIC ACID Chemical Properties,Usage,Production
Chemical Properties
gold crystalline solid
Uses
antineoplastic
Uses
3-Nitropropionic acid has been used:
- to generate multiple system atropy-parkinsoniam (MSA-P) model in rat to evaluate its effect on embryonic striatal and mesencephalic grafts
- to inject into the nigrostriatal dopaminergic pathway in rats in order to examine its specific effects on the dopamine system
- as succinate dehydrogenase (SDH) inhibitor for LUHMES neurons and cell lines
Definition
ChEBI: 3-nitropropanoic acid is a C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group. It has a role as a neurotoxin, an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor, an antimycobacterial drug and a mycotoxin. It is functionally related to a propionic acid. It is a conjugate acid of a 3-nitropropanoate. It is a tautomer of a 3-aci-nitropropanoic acid.
General Description
Golden crystals (from chloroform).
Air & Water Reactions
Water soluble.
Reactivity Profile
3-NITROPROPIONIC ACID is incompatible with bases, oxidizing agents and reducing agents.
Fire Hazard
Flash point data for 3-NITROPROPIONIC ACID are not available; however, 3-NITROPROPIONIC ACID is probably combustible.
Biological Activity
3-nitropropionic acid is an irreversible inhibitor of mitochondrial respiratory complex ii (succinate dehydrogenase), which impairs cellular energy metabolism by inhibiting succinate dehydrogenase and reducing atp production. also, 3-nitropropionic acid can cause the generation and release of reactive oxygen species (ros) from mitochondria (the main source of cellular oxidative stress), mitochondrial dna damage, as well as loss of mitochondrial function.1. huang ls, sun g, cobessi d, et al. 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex ii, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. journal of biological chemistry, 2006, 281(9): 5965-5972.2. zhang jq, shen m, zhu cc, et al. 3-nitropropionic acid induces ovarian oxidative stress and impairs follicle in mouse. plos one, 2014, 9(2): e86589.3. mandavilli bs, boldogh i, van houten b. 3-nitropropionic acid-induced hydrogen peroxide, mitochondrial dna damage, and cell death are attenuated by bcl-2 overexpression in pc12 cells. brain research. molecular brain research, 2005, 133(2): 215-223.
Biochem/physiol Actions
Excitotoxin shown to cause brain lesions similar to those of Huntington′s disease.
Safety Profile
Poison by intravenous andintraperitoneal routes. Questionable carcinogen withexperimental neoplastigenic data. Mutation data reported.When heated to decomposition it emits toxic fumes ofNOx.
3-NITROPROPIONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-NITROPROPIONIC ACID manufacturers
- Product
- 3-NITROPROPIONIC ACID 504-88-1
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- ＞98% HPLC
- Supply Ability
- 20 tons
- Release date
- 2020-02-17