4-Chloro-3-hydroxybenzoic acid

Product Name: 4-Chloro-3-hydroxybenzoic acid
CAS No.: 34113-69-4
Chemical Name: 4-Chloro-3-hydroxybenzoic acid
Synonyms: TIMTEC-BB SBB008503;5-Carboxy-2-chlorophenol;4-chloro-3-hydroxybenzoicaci;4-CHLORO-3-HYDROXYBENZOIC ACID;Benzoic acid, 4-chloro-3-hydroxy-;4-Chloro-3-hydroxybenzoic Acid, 97+%;4-CHLORO-3-HYDROXYBENZOIC ACID ---PURITY 98%---
CBNumber: CB4368988
Molecular Formula: C7H5ClO3
Formula Weight: 172.57
MOL File: 34113-69-4.mol

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4-Chloro-3-hydroxybenzoic acid Property

Melting point:: 219.5-220.5 °C
Boiling point:: 345.4±27.0 °C(Predicted)
Density: 1.536±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO, Methanol
form: Solid
pka: 3.85±0.10(Predicted)
color: Light Beige
InChI: InChI=1S/C7H5ClO3/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,9H,(H,10,11)
InChIKey: SCPUNJAMWFAYED-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(Cl)C(O)=C1
CAS DataBase Reference: 34113-69-4(CAS DataBase Reference)
NIST Chemistry Reference: Benzoic acid, 4-chloro-3-hydroxy-(34113-69-4)

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2918199890

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C366565
Product name: 4-Chloro-3-hydroxybenzoicAcid
Packaging: 1g
Price: $120
Updated: 2021/12/16

Usbiological

Product number: 161302
Product name: 4-Chloro-3-hydroxybenzoic Acid
Packaging: 1g
Price: $403
Updated: 2021/12/16

TRC

Product number: C366565
Product name: 4-Chloro-3-hydroxybenzoicAcid
Packaging: 25g
Price: $470
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC70409
Product name: 4-Chloro-3-hydroxybenzoic acid
Packaging: 100g
Price: $600
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0013088
Product name: 4-CHLORO-3-HYDROXYBENZOIC ACID
Purity: 95.00%
Packaging: 1G
Price: $682.28
Updated: 2021/12/16

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4-Chloro-3-hydroxybenzoic acid Chemical Properties,Usage,Production

Uses

4-Chloro-3-hydroxy-Benzoic Acid acts as a potential inhibitor of influenza endonuclease used in the treatment of influenza. Also used in the synthesis of highly selective Tie-2 kinase inhibitors used in the treatment of tumors.

Synthesis

931409-94-8

34113-69-4

General procedure for the synthesis of 4-chloro-3-hydroxybenzoic acid from compound (CAS: 931409-94-8): boron tribromide (1 M in dichloromethane, 31 mL, 31.504 mmol) was slowly added dropwise to a solution of compound 38 (3.56 g, 15.752 mmol) in dichloromethane (30 mL) under ice bath cooling conditions. The reaction mixture was stirred at 0°C to room temperature for 18 hours. Upon completion of the reaction, the reaction was quenched with 0.88 aqueous ammonia solution and stirring was continued for 90 minutes at room temperature. Subsequently, the reaction mixture was acidified to pH 1 by dropwise addition of 2N aqueous hydrochloric acid solution and then extracted with ether (2 x 50 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 4-chloro-3-hydroxybenzoic acid as a light yellow solid in 90% yield (2.45 g). The product was characterized by 1H NMR (400 MHz, CD3OD): δ 7.36-7.38 (d, 1H), 7.44-7.47 (dd, 1H), 7.54-7.55 (d, 1H); LRMS APCI m/z 171 [M-H]-.

References

[1] Patent: WO2007/34325, 2007, A1. Location in patent: Page/Page column 53

4-Chloro-3-hydroxybenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Chloro-3-hydroxybenzoic acid manufacturers

Career Henan Chemical Co

Product: 4-Chloro-3-hydroxybenzoic acid 34113-69-4
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-31

34113-69-4, 4-Chloro-3-hydroxybenzoic acidRelated Search:

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4-CHLORO-3-HYDROXYBENZOIC ACID

4-CHLORO-3-HYDROXYBENZOIC ACID ---PURITY 98%---

TIMTEC-BB SBB008503

5-Carboxy-2-chlorophenol

4-Chloro-3-hydroxybenzoic Acid, 97+%

Benzoic acid, 4-chloro-3-hydroxy-

4-chloro-3-hydroxybenzoicaci

34113-69-4

1571-12-8

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